January 26, 2009
Man with cranial neuropathies, enlarged neck nodes, and brown-red skin lesions.
Rosai-Dorfman Disease
- Aka: sinus histiocytosis with massive adenopathy (due to infiltrates of histiocytes and lymphoplasmacytic cells, CD1a-, a marker for histiocytosis X-, is absent).
- Young men and children.
- Most frequent intracranial locations: convexities, parasagittal, suprasellar, cavernous sinuses, and clivus (lesions may simulate meningioma, sarcoid, lymphoma, or metastases to dura)
- Surgical resection is the best treatment.
