Evaluation of an Intravenous-Endovascular Strategy in Patients with Acute Proximal Middle Cerebral Artery Occlusion

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Fig. 1.
Flowchart of patients and outcome at 3 months.

Table 1:

Patient characteristics before treatment

↵a For comparison between IVT and IES (Fisher exact test or t test for continuous variables).

Table 2:

Initial and midterm results

	IVT (n = 30)	IES (n = 22)	P Value^{^a}
Initial treatment efficacy (24 hr)
Mean NIHSS difference at 24 hrs from baseline (SD)	−2.8 (2.7)	−8.0 (7.5)	.001
NIHSS improvement >4	10 (35.7%)	15 (71.4%)	.01
NIHSS = 0	4 (33.3%)	8 (66.7%)	.05
Midterm treatment efficacy (3 months)
mRS ≤2	15 (50.0%)	17 (77.3%)	.08
mRS >2	15 (50.0%)	5 (21.7%)

Table 3:

Multivariable analysis of favorable clinical outcome at 3 months

	OR (95% CI)^{^a}	P Value^{^b}	adjOR (95% CI)^{^a}	P Value^{^b}
IES	2.99 (0.86–12.3)	.08	11.9 (1.6–89.1)	.02
Initial NIHSS <15	0.78 (0.67–0.90)	.001	12.5 (1.8–87.0)	.01
MRI ASPECTS >7	3.2 (0.90–11.3)	.007	4.9 (0.8–31.0)	.09
Diabetes	0.12 (0.02–0.65)	.01	0.13 (0.01–1.7)	10
Time to treatment	1.00 (0.99–1.02)	.63	—	—
Dyslipidemia	0.45 (0.14–1.49)	.19	—	—
Sex (male)	0.88 (0.28–2.80)	.83	—	—
Age	0.98 (0.93–1.03)	.45	—	—
Current smoker	0.75 (0.23–2.43)	.64	—	—
Hypertension	0.49 (0.15–1.62)	.25	—	—

Note:—OR indicates odds ratio; adjOR, adjusted odds ratio.
↵a OR and adjOR values comparing the 3-month clinical outcome between IVT and IES, after adjustment for confounding factors using an exact logistic regression.
↵b P for comparison between IVT and IES (χ² test or Fisher exact test).