RT Journal Article
SR Electronic
T1 The Utility of the Microcrystalline Cellulose Sphere as a Particulate Embolic Agent:An Experimental Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1160
OP 1163
VO 21
IS 6
A1 Kai, Yutaka
A1 Hamada, Jun-ichiro
A1 Morioka, Motohiro
A1 Todaka, Tatemi
A1 Hasegawa, Shu
A1 Ushio, Yukitaka
YR 2000
UL http://www.ajnr.org/content/21/6/1160.abstract
AB BACKGROUND AND PURPOSE: Although various particulate materials have been developed as embolization agents, their biocompatibility remains unclear. We used an animal model to examine the possibility of using FDA-approved microcrystalline cellulose spheres (CELPHERE) as solid embolic material for the permanent occlusion of blood vessels.METHODS: Angiographic and histologic studies in 12 canine renal arterial systems were conducted to evaluate the performance of CELPHERE beads at 1 hour, and at 4 and 12 weeks after embolization.RESULTS: The CELPHERE beads traveled to vessels with diameters approximating their own. Larger vessels were occluded by aggregations of beads. There was no disruption of vessel walls and no evidence of perivascular hemorrhage or inflammatory changes.CONCLUSION: Because CELPHERE beads are easy to handle, highly biocompatible, and have few adverse effects, they are suitable for intravascular applications.