PT  - JOURNAL ARTICLE
AU  - van der Knaap, M.S.
AU  - Kriek, M.
AU  - Overweg-Plandsoen, W.C.G.
AU  - Hansson, K.B.
AU  - Madan, K.
AU  - Starreveld, J.S.
AU  - Schotman-Schram, P.
AU  - Barkhof, F.
AU  - Oberstein, S.A.M.J. Lesnik
TI  - Cerebral White Matter Abnormalities in 6p25 Deletion Syndrome
DP  - 2006 Mar 01
TA  - American Journal of Neuroradiology
PG  - 586--588
VI  - 27
IP  - 3
4099  - http://www.ajnr.org/content/27/3/586.short
4100  - http://www.ajnr.org/content/27/3/586.full
SO  - Am. J. Neuroradiol.2006 Mar 01; 27
AB  - Summary: Submicroscopic deletion of the terminal part of the short arm of chromosome 6, including 6p25, leads to developmental retardation, hearing impairment, ocular dysgenesis, and dysmorphic features. We diagnosed 3 patients referred because of white matter abnormalities of unknown origin. MR imaging showed multifocal areas of abnormal signal and enlarged perivascular spaces in the cerebral white matter that were stable during follow-up. Multifocal white matter abnormalities are most commonly seen in static, nonmetabolic encephalopathies, including chromosomal abnormalities.