RT Journal Article SR Electronic T1 Cerebral White Matter Abnormalities in 6p25 Deletion Syndrome JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 586 OP 588 VO 27 IS 3 A1 van der Knaap, M.S. A1 Kriek, M. A1 Overweg-Plandsoen, W.C.G. A1 Hansson, K.B. A1 Madan, K. A1 Starreveld, J.S. A1 Schotman-Schram, P. A1 Barkhof, F. A1 Oberstein, S.A.M.J. Lesnik YR 2006 UL http://www.ajnr.org/content/27/3/586.abstract AB Summary: Submicroscopic deletion of the terminal part of the short arm of chromosome 6, including 6p25, leads to developmental retardation, hearing impairment, ocular dysgenesis, and dysmorphic features. We diagnosed 3 patients referred because of white matter abnormalities of unknown origin. MR imaging showed multifocal areas of abnormal signal and enlarged perivascular spaces in the cerebral white matter that were stable during follow-up. Multifocal white matter abnormalities are most commonly seen in static, nonmetabolic encephalopathies, including chromosomal abnormalities.