PT  - JOURNAL ARTICLE
AU  - Kantarci, K.
AU  - Senjem, M.L.
AU  - Lowe, V.J.
AU  - Wiste, H.J.
AU  - Weigand, S.D.
AU  - Kemp, B.J.
AU  - Frank, A.R.
AU  - Shiung, M.M.
AU  - Boeve, B.F.
AU  - Knopman, D.S.
AU  - Petersen, R.C.
AU  - Jack, C.R.
TI  - Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment
AID  - 10.3174/ajnr.A2070
DP  - 2010 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1247--1253
VI  - 31
IP  - 7
4099  - http://www.ajnr.org/content/31/7/1247.short
4100  - http://www.ajnr.org/content/31/7/1247.full
SO  - Am. J. Neuroradiol.2010 Aug 01; 31
AB  - BACKGROUND AND PURPOSE: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI. MATERIALS AND METHODS: Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (>73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age. RESULTS: The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres CONCLUSIONS: Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI. AALautomated anatomic labelingADAlzheimer diseaseADRC/ADPRAlzheimer's Disease Research Center/Alzheimer's Disease Patient RegistryaMCIamnestic mild cognitive impairmentCDRClinical Dementia RatingCNcognitively normalDCTdiscrete cosine transformationFDG-PETfluorodeoxyglucose–positron-emission tomographyFLAIRfluid-attenuated inversion recoveryIQRinterquartile rangeMCImild cognitive impairmentMMSEMini-Mental State ExaminationSPMstatistical parametric mappingVBMvoxel-based morphometryWMHwhite matter hyperintensities