PT  - JOURNAL ARTICLE
AU  - Schneider, T.
AU  - Hom, J.
AU  - Bredno, J.
AU  - Dankbaar, J.W.
AU  - Cheng, S.-C.
AU  - Wintermark, M.
TI  - Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT
AID  - 10.3174/ajnr.A2152
DP  - 2011 Aug 01
TA  - American Journal of Neuroradiology
PG  - E134--E138
VI  - 32
IP  - 7
4099  - http://www.ajnr.org/content/32/7/E134.short
4100  - http://www.ajnr.org/content/32/7/E134.full
SO  - Am. J. Neuroradiol.2011 Aug 01; 32
AB  - SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT. ACAanterior cerebral arteryAIFarterial input functionBBBblood-brain barrierBBBPblood-brain barrier permeabilityCBFcerebral blood flowCBVcerebral blood volumeCIconfidence intervalCTACT angiographyFLAIRfluid-attenuated inversion recoveryGEEgeneralized estimating equationsMCAmiddle cerebral artery√MSEroot mean squared errorsMSEmean squared errorMTTmean transit timeNCCTnoncontrast CTPCAposterior cerebral arteryPCTperfusion CTPETpositron-emission tomographyRIFregion input functionrtPArecombinant tissue plasminogen activatorTTPtime to peak