RT Journal Article
SR Electronic
T1 Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 984
OP 989
DO 10.3174/ajnr.A3332
VO 34
IS 5
A1 Uetani, H.
A1 Hirai, T.
A1 Hashimoto, M.
A1 Ikeda, M.
A1 Kitajima, M.
A1 Sakamoto, F.
A1 Utsunomiya, D.
A1 Oda, S.
A1 Sugiyama, S.
A1 Matsubara, J.
A1 Yamashita, Y.
YR 2013
UL http://www.ajnr.org/content/34/5/984.abstract
AB BACKGROUND AND PURPOSE: The prevalence and topography of small hypointense foci suggesting microbleeds on 3T SWI in various types of dementia have not been systematically investigated. The purpose of this study was to determine the prevalence and topography of SHF on 3T SWI in patients with different dementia subtypes. MATERIALS AND METHODS: We included 347 consecutive patients (217 women, 130 men; age range, 42–93 years; mean age, 74 years) who attended our memory clinic and underwent 3T SWI. They were divided into 6 groups: subjective complaints, MCI, AD, DLB, VaD, and FTLD. Two neuroradiologists evaluated the number and location of SHF on SWIs. Statistical analyses were performed to evaluate inter- and intragroup differences. RESULTS: Of the 347 patients, 160 (46.1%) exhibited at least 1 small hypointense focus. This was true in 86% with VaD, 54% with DLB, 48% with AD, 41% with MCI, 27% with FTLD, and 22% with subjective complaints. With the subjective complaints group as a reference, the odds ratio adjusted by age, sex, and arterial hypertension was 9.2 (95% CI, 2.0–43.6) for VaD; 5.4 (95% CI, 1.2–24.3) for AD; 3.1 for DLB (95% CI, 1.1–8.8); 2.0 for MCI (95% CI, 0.5–8.1); and 1.5 for FTLD (95% CI, 0.4–5.4). There was a significant lobar predilection for AD, DLB, and FTLD groups (P < .05). CONCLUSIONS: On 3T SWI, patients with VaD, AD, and DLB manifested a high SHF prevalence. In patients with AD, DLB, and FTLD, the SHF exhibited a lobar predilection. ADAlzheimer diseaseCIconfidence intervalDLBdementia with Lewy bodiesFTLDfrontotemporal lobar dementiaMCImild cognitive impairmentSHFsmall hypointense fociVaDvascular dementia