RT Journal Article
SR Electronic
T1 Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1556
OP 1559
DO 10.3174/ajnr.A3456
VO 34
IS 8
A1 Niemczyk, M.
A1 Gradzik, M.
A1 Niemczyk, S.
A1 Bujko, M.
A1 Gołębiowski, M.
A1 Pączek, L.
YR 2013
UL http://www.ajnr.org/content/34/8/1556.abstract
AB BACKGROUND AND PURPOSE: ADPKD correlates with an increased frequency of ICANs, but universal screening for ICANs in patients with ADPKD is not currently recommended. The aim of our study was to determine which groups might benefit from screening by determining the prevalence of ICANs in the Polish ADPKD population and identifying any subgroups with an increased risk for ICANs. MATERIALS AND METHODS: Eighty-three adult, predialysis-phase patients with ADPKD underwent screening for ICANs with MRA of the brain. RESULTS: The prevalence of ICANs in the studied population was 16.9%, with 6% of the screened group requiring neurosurgical intervention. We also found that the frequency of ICANs increases with age, reaching 22.4% in patients older than 45 years. All diagnosed ICANs were small (< 9 mm) and were localized in the anterior circulation. In addition, MR imaging revealed arachnoid cysts in 4.8% of patients with ADPKD. CONCLUSIONS: We suggest that patients older than 45 years with ADPKD be considered as candidates for screening for ICANs, and we propose a clinical algorithm for this subgroup. However, we could not find risk factors for ICANs in younger patients with ADPKD. ADPKDautosomal dominant polycystic kidney diseaseAHarterial hypertensionCKDchronic kidney diseaseICANintracranial aneurysmCIconfidence interval