PT  - JOURNAL ARTICLE
AU  - Mohebbi, Maryam
AU  - Reeves, Jack A.
AU  - Jakimovski, Dejan
AU  - Bartnik, Alexander
AU  - Bergsland, Niels
AU  - Salman, Fahad
AU  - Schweser, Ferdinand
AU  - Weinstock-Guttman, Bianca
AU  - Zivadinov, Robert
AU  - Dwyer, Michael G.
TI  - Diffusion- and Tractography-Based Characterization of Tissue Damage Within and Surrounding Paramagnetic Rim Lesions in Multiple Sclerosis
AID  - 10.3174/ajnr.A8524
DP  - 2025 Mar 01
TA  - American Journal of Neuroradiology
PG  - 611--619
VI  - 46
IP  - 3
4099  - http://www.ajnr.org/content/46/3/611.short
4100  - http://www.ajnr.org/content/46/3/611.full
SO  - Am. J. Neuroradiol.2025 Mar 01; 46
AB  - BACKGROUND AND PURPOSE: Paramagnetic rim lesions (PRLs) are an imaging biomarker of chronic inflammation in MS that are associated with more aggressive disease. However, the precise tissue characteristics and extent of their damage, particularly with regard to connected axonal tracts, are incompletely understood. Quantitative diffusion tissue measurements and fiber tractography can provide a more complete picture of these phenomena.MATERIALS AND METHODS: One hundred fifteen people with MS were enrolled in this study. Quantitative susceptibility mapping and DWI were acquired on a 3T MRI scanner. PRLs were identified in 49 (43%) subjects. Diffusion tractography was then used to identify nearby PRL-connected versus non-PRL connected tracts and PRL-connected versus nonconnected surrounding tracts. DWI metrics, including fractional anisotropy (FA), quantitative anisotropy (QA), mean diffusivity, axial diffusivity, radial diffusivity, isotropy, and restricted diffusion imaging, were compared between these tracts and within PRLs and non-PRL lesions themselves.RESULTS: Tissue within PRLs had significantly lower FA than tissue within non-PRL T2 lesions (P = .04). Tracts connected to PRLs exhibited significantly lower FA (P < .001), higher restricted diffusion imaging (P = .02, and higher Iso values (P = .007) than tracts connected to non-PRL T2 lesions. Only QA was different between tracts connected to PRLs and nonconnected surrounding tracts (P = .003).CONCLUSIONS: PRLs are more destructive both within themselves and to surrounding tissue. This damage appears more spatially than axonally mediated.ADaxial diffusivityCALchronic active lesionDKIdiffusional kurtosis imagingFAfractional anisotropyFDRfalse discovery rateFLIPflip angleFSLFMRIB’s Software LibraryGQIgeneralized q-sampling imagingIsoisotropyLVlesion volumeMDmean diffusivityPRLparamagnetic rim lesionpwMSpeople with MSQAquantitative anisotropyQSMquantitative susceptibility mappingRDradial diffusivityRDIrestricted diffusion imagingRRMSrelapsing-remitting MSSDFspin distribution functionT1wT1-weighted