TABLE 1:

Differences in slopes between patients who received reduced (23.4 Gy) or conventional (36–39.6 Gy) craniospinal irradiation doses

CC RegionCSI Dose (Gy)Slope*Significance†
TotalReduced−20.00.52
Conventional−16.0
RostrumReduced0.20.29
Conventional1.4
GenuReduced−0.10.20
Conventional−4.6
Rostral bodyReduced−2.40.55
Conventional−1.2
Anterior midbodyReduced−1.60.81
Conventional−1.2
Posterior midbodyReduced−1.40.98
Conventional−1.4
IsthmusReduced−2.00.75
Conventional−2.2
SpleniumReduced−7.00.17
Conventional−2.4

  • Note.—CC indicates corpus callosum; CSI, craniospinal irradiation.

  • * Change in CC size per year since start of CSI (mm2).

  • † Testing H0: slope (reduced) = slope (conventional); P < .05, two-tailed test.