Results of the individual linear regression models predicting cognition for each individual MRI measure
| Semantic | Episodic | Executive | Spatial | |
|---|---|---|---|---|
| GM | 6.14 (1.90)P = .001* | 10.87 (1.92) P < .001* | 6.95 (1.46)P < .001* | 7.65 (2.07)P < .001* |
| WMH | −.06 (0.05)P = .27 | −.16 (.06)P = .0068 | −.09 (.04)P = .04 | −.08 (.06)P = .17 |
| FA-CC | .91 (.86)P = .30 | 1.82 (.92)P = .05 | 1.24 (.68)P = .07 | 1.70 (.93)P = .07 |
| FA-Cingulum | .11 (.58)P = .85 | 1.80 (.62)P = .004* | 1.32 (.46)P = .005* | 1.28 (.61)P = .04 |
| FA-Fornix | .83 (.70)P = .24 | 2.78 (.75)P < .001* | 1.71 (.57)P < .003* | 2.10 (.74)P < .005* |
| FA-SLF | .27 (.82)P = .74 | .67 (.89)P = .45 | .69 (.67)P = .30 | 1.18 (.88)P = .18 |
| FA-UNC | 1.45 (.80)P = .07 | 1.90 (.86)P = .03 | 1.49 (.64)P = .02 | 1.98 (.85)P = .02 |
Note:—Estimated from separate linear regression models that controlled for gender, education, and recruitment source. The α level was set at .01 to account for the 4 outcome measures (.05/4 = .0125). FA indicates ratio of young adults fractional anistropy value; GM, percentage of total cranial volume; WMH, white matter hyperintensities (log-transformed percentage of total cranial volume).
↵* Indicates P values not larger than the α level which was set at .0125.