Table 1:

Demographic, clinical, and imaging data for all older HC in this study, as assessed by P-τ and Aβ status

	P-τ−/Aβ− (n = 46)	P-τ−/Aβ+ (n = 20)	P-τ+/Aβ− (n = 19)	P-τ+/Aβ+ (n = 21)	P Value
Age (yr) (mean) (SE)	74.3 (0.6)	74.9 (1.1)	78.0 (1.4)	78.2 (1.0)	.02^{^a}
Female (%)	24	31	29	38	.59^{^b}
Education (yr) (mean) (SE)	15.5 (0.4)	14.8 (0.8)	15.5 (0.4)	16.7 (0.6)	.34^{^a}
Baseline MMSE (mean) (SE)	29.1 (0.1)	29.1 (0.2)	28.8 (0.3)	29.3 (0.2)	.46^{^a}
Entorhinal cortex APC (mean) (SE)	−0.6 (0.15)	−0.6 (0.18)	−0.6 (0.18)	−1.2 (0.25)	.005^{^c}
AD-vulnerable ROI APC (mean) (SE)	−0.6 (0.08)	−0.5 (0.11)	−0.7 (0.14)	−1.1 (0.14)	.002^{^c}

Note:—MMSE indicates Mini-Mental State Examination; APC = annualized percentage change.
↵a Derived from analysis of variance.
↵b Derived from a χ² test.
↵c Derived from linear mixed-effects models (please see text for details).