Table 2:

Demographic, clinical, and imaging data for all older HC in this study, as assessed by APOE ε4 and Aβ status

	ε4−/Aβ− (n = 61)	ε4−/Aβ+ (n = 21)	ε4+/Aβ− (n = 5)	ε4+/Aβ+ (n = 20)	P Value
Age (yr) (mean) (SE)	75.7 (0.7)	76.2 (0.9)	71.7 (2.5)	77.1 (1.3)	.56^{^a}
Female (%)	54	54	20	35	.23^{^b}
Education (yr) (mean) (SE)	15.6 (0.3)	15.9 (0.6)	15 (1.1)	15.6 (0.8)	.98^{^a}
Baseline MMSE (mean) (SE)	29.1 (0.1)	29.4 (0.2)	28.6 (0.9)	29 (0.2)	.73^{^a}
Entorhinal cortex APC (mean) (SE)	−0.57 (0.13)	−0.67 (0.17)	−0.43 (0.30)	−1.17 (0.28)	.35^{^c}
AD-vulnerable ROI APC (mean) (SE)	−0.6 (0.07)	−0.78 (0.14)	−0.65 (0.23)	−1.0 (0.16)	.28^{^c}

Note:—MMSE indicates Mini-Mental State Examination; APC = annualized percentage change.
↵a Derived from analysis of variance.
↵b Derived from a χ² test.
↵c Derived from linear mixed-effects models (please see text for details).