Detection of histologically confirmed brain tumors on MR images acquired after administration of 0.1-mmol/kg gadoteridol or 0.1-mmol/kg gadobutrol in 139 patients with 308 brain lesions subsequently confirmed at biopsy or surgery
| Lesion Detection | Reader 1 | Reader 2 | Reader 3 | |||
|---|---|---|---|---|---|---|
| Gadoteridol | Gadobutrol | Gadoteridol | Gadobutrol | Gadoteridol | Gadobutrol | |
| No. patients with tumors detected at MRI | 133 (95.7%) | 135 (97.1%) | 137 (98.6%) | 136 (97.8%) | 136 (97.8%) | 132 (95.0%) |
| P value (95% CI of difference, %) | .317 (−4.2 to 1.4) | .564 (−1.7 to 3.2) | .046 (0.1 to 5.7) | |||
| No. tumors detected at MRI | 240 (77.9%) | 236 (76.6%) | 269 (87.3%) | 263 (85.4%) | 230 (74.7%) | 220 (71.4%) |
| P value (95% CI of difference, %) | 0.480 (−2.3 to 4.9) | 0.239 (−1.3 to 5.2) | 0.018 (0.6 to 5.9) | |||