Clinical and radiologic characteristics of the study populationa
| Characteristic | Linear GBCA–Exposed Children | Macrocyclic GBCA–Exposed Children | GBCA-Naive Control Subjects |
|---|---|---|---|
| Age (yr) | |||
| Mean (SD) | 8.2 (SD, 5.4) | 8.2 (SD, 5.1) | 8.2 (SD, 3.6) |
| Range | 2–18 | 2–18 | 2–18 |
| Sex | |||
| Male | 23 | 23 | 23 |
| Female | 10 | 10 | 10 |
| Mean (SD) No. of contrast-enhanced MR imaging | 2.4 (SD, 2.4) | 4.03 (SD, 2.9) | 0 |
| Mean (SD) time interval between MR imaging (mo) | 7.16 (SD, 7.5) | 7.4 (SD, 7.3) | 0 |
| Mean (SD) accumulated gadolinium dose (mmol) | 17.5 (SD, 24.1) | 13.3 (SD, 11.9) | 0 |
| Diagnosis | |||
| Intracranial neoplasm | 7 | 7 | 10 |
| Extracranial neoplasm | 2 | 0 | 1 |
| Pituitary abnormality | 3 | 6 | 2 |
| Orbit/optic nerve pathology | 6 | 7 | 2 |
| Adrenoleukodystrophy | 5 | 5 | 10 |
| Benign conditions | 10 | 8 | 8 |
| History of radiation treatment | 3 | 2 | 3 |
| History of chemotherapy | 6 | 5 | 4 |
| History of neurosurgery | 2 | 2 | 3 |
↵a Data are number of patients unless indicated otherwise and mean (SD).