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American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

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    Fig 1.

    Axial MR image (TR/TE, 10,002/142) obtained when the patient was aged 5 days shows extensive areas of abnormal signal intensity, which suggest edema involving the bilateral cerebral white matter and bilateral parietal and occipital gray matter. The bilateral frontal and temporal cortex, as well as parts of the basal ganglia, are probably spared. Ventricular size is normal.

  • Fig 2.
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    Fig 2.

    Axial MR image (10,002/142) obtained when the patient was aged 12 days demonstrates ventricular size and sulcal prominence have increased since the study performed 1 week earlier. New curvilinear area of decreased signal intensity at the gray matter–white matter junction is present; it suggests hemorrhagic deposits and laminar necrosis.

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    Fig 3.

    Axial MR images obtained when the patient was aged 31 days demonstrate dramatic changes compared with findings on initial images. Extensive new cystic cavities are within the bilateral parietal, frontal, and temporal lobes and are medial to the insular cortex in both hemispheres. While global thinning of the cerebral cortex is present, this atrophy is most marked in the subinsular and parietal regions. Abnormal signal intensity is present within the bilateral basal ganglia, including the caudate, globus pallidus, and putamen, internal capsules, and centrum semiovale. Enlargement of ventricles and sulci is consistent with neuronal loss.

    A, TR/TE, 10,002/147.

    B, TR/TE, 516/8.

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