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Diffuse Leptomeningeal Hyperintensity on Fluid-Attenuated Inversion Recovery MR Images in Neurocutaneous Melanosis

Masato Hayashi, Masayuki Maeda, Tomoaki Maji, Toshio Matsubara, Hirokazu Tsukahara and Kan Takeda
American Journal of Neuroradiology January 2004, 25 (1) 138-141;
Masato Hayashi
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Masayuki Maeda
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Tomoaki Maji
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Toshio Matsubara
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Hirokazu Tsukahara
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Kan Takeda
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    Fig 1.

    Initial MR imaging 3 days after the CT study.

    A, T1-weighted image (616/14) shows a high signal intensity focus in the area of the right frontal lobe (arrow). Other high signal intensity foci are seen at multiple sites (small arrows).

    B, T2*-weighted image (GRE, 400/20/FA 20) shows a low-signal intensity focus in the corresponding area of the right frontal lobe (arrow), which was confirmed as hemorrhage at surgery. No other low signal intensity lesions are seen.

    C and D, FLAIR images (8002/133/2000) show diffuse leptomeningeal hyperintensity in the sulci (small arrows).

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    Fig 2.

    Follow-up MR imaging 3 weeks after the initial MR study.

    A, T1-weighted image (616/14) shows high signal intensity in both trigeminal nerves (arrows). High signal intensity foci are also seen in the cerebellar sulci (small arrow). Note that hydrocephalus has progressed.

    B, FLAIR image (8002/133/2000) shows diffuse leptomeningeal hyperintensity (small arrows). Both trigeminal nerves are thickened and hyperintense (arrows).

    C, Contrast-enhanced T1-weighted image (616/14) shows diffuse leptomeningeal enhancement corresponding to the findings of FLAIR imaging.

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    Fig 3.

    Appearance at surgery. Diffuse black pigmentation of the leptomeninges is noted.

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    Fig 4.

    A, Photomicrograph (hematoxylin and eosin stain, × 400) shows the atypical cells with dark melanin pigment. The mitotic figures were frequently observed in the neoplasm.

    B, Photomicrograph shows a strongly positive immunohistochemical reaction to antimelanoma antibody (HMB-45).

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American Journal of Neuroradiology: 25 (1)
American Journal of Neuroradiology
Vol. 25, Issue 1
1 Jan 2004
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Cite this article
Masato Hayashi, Masayuki Maeda, Tomoaki Maji, Toshio Matsubara, Hirokazu Tsukahara, Kan Takeda
Diffuse Leptomeningeal Hyperintensity on Fluid-Attenuated Inversion Recovery MR Images in Neurocutaneous Melanosis
American Journal of Neuroradiology Jan 2004, 25 (1) 138-141;

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Diffuse Leptomeningeal Hyperintensity on Fluid-Attenuated Inversion Recovery MR Images in Neurocutaneous Melanosis
Masato Hayashi, Masayuki Maeda, Tomoaki Maji, Toshio Matsubara, Hirokazu Tsukahara, Kan Takeda
American Journal of Neuroradiology Jan 2004, 25 (1) 138-141;
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  • Neurocutaneous melanosis: a rare manifestation of congenital melanocytic nevus
  • Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part I: pathological conditions
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