Article Figures & Data
Figures
- Fig 1.
Magnified coronal high-resolution T1-weighted images of the hippocampal region.
A and B, Coronal T1-weighted image of a 68-year-old nondemented control showing discrete enlargement of the choroidal fissures (cf), suggesting medial temporal lobe atrophy (MTA) grade 1, and hippocampal cavities bilaterally (vertical arrows). Note that both hippocampal sulci are not enlarged (horizontal arrows).
C and D, Coronal T1-weighted image of a 54-year-old patient with Alzheimer disease showing enlargement of the hippocampal sulcus, measured between the fimbria and the subiculum (vertical measurement overlays), and enlargement of the choroidal fissures (cf) (MTA grade 1).
E and F, Coronal T1-weighted image of a 76-year-old patient with Alzheimer disease showing enlargement of the hippocampal sulcus (vertical measurement overlays), moderate-to-severe MTA (grade 3) and hippocampal cavities bilaterally (vertical arrows).
G and H, Coronal T1-weighted image of a 93-year-old patient with Alzheimer disease showing severe MTA (grade 4) and a small hippocampal cavity on the right side (vertical arrow). Note that the fimbria appears laterally displaced; this displacement contributes to an increase of the fimbriosubicular distance (oblique measurement overlays).
- Fig 2.
Scatterplots displaying the averaged left/right hippocampal sulcus width (fimbriosubicular distance) plotted against the medial temporal atrophy score. Triangles represent patients with Alzheimer disease, and circles correspond to control subjects.
Tables
- Table 1:
Characteristics of patients with Alzheimer disease (AD) (n = 21) and nondemented elderly control subjects (n = 15) including age, mini-mental state examination (MMSE), hippocampal sulcus (HS) width, number and size of hippocampal cavities (HC), and medial temporal lobe atrophy (MTA) score
Characteristic Mean (SD) AD Patients Control Subjects P Value Age 69.3 (10.9) 68.9 (8.0) .91 MMSE score* 18.8† (4.5) 27.9† (1.9) <.0001 HS width‡ (mm), observer 1 2.9 (1.0) 1.4 (0.6) <.0001 HS width‡ (mm), observer 2 2.8 (1.1) 1.4 (0.7) <.0001 HS width‡ (mm), interobserver average 2.8 (0.9) 1.4 (0.6) <.0001 Number of HC, observer 1 2.6 (3.2) 3.6 (2.8) .32 Number of HC, observer 2 1.9 (2.4) 3.6 (2.9) .06 Number of HC, interobserver average 2.2 (2.7) 3.6 (2.8) .15 Mean size of HC (mm), observer 1 1.7 (1.0) 2.0 (1.1) .29 Mean size of HC (mm), observer 2 1.3 (1.1) 2.0 (0.8) .06 Mean size of HC (mm), interobserver average 1.5 (0.9) 2.0 (0.9) .10 MTA score‡§, observer 1 2.2† (1.0) 1.1† (0.7) <.01 MTA score‡§, observer 2 1.7† (1.1) 0.6† (0.7) <.01 MTA score‡§, interobserver average 2.0† (1.1) 0.8† (0.6) <.01 Note:—
* Lower values indicate greater severity.
† Please note that means of scores are presented, whereas we used the Mann-Whitney U test to compare differences between groups.
‡ Values are left/right averages.
§ Higher values indicate greater severity.
- Table 2:
Interobserver averaged hippocampal sulcus (HS) width (fimbriosubicular distance) according to grade of medial temporal lobe atrophy (MTA) in patients with Alzheimer disease (AD) (n = 21) and nondemented elderly control subjects (n = 15)
MTA score Mean HS Width in mm (SD) P Value AD Patients Control Subjects 0 (n = 3) 1.4 (0.5) 1 (n = 18) 2.1 (0.5) 1.3 (0.7) P < 0.05 2 (n = 6) 2.5 (0.1) 1.7 (0.4) P < 0.05 3 (n = 6) 3.5 (0.4) 4 (n = 3) 4.1 (1.1)
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