Clinical Experience of Selective Intra-Arterial Nimodipine Treatment for Cerebral Vasospasm Following Subarachnoid Hemorrhage

Reply:

Thank you very much for the opportunity to give our reflections on comments by Biondi and colleagues regarding our study showing the effectiveness of intra-arterial nimdipine treatment in an animal subarachnoid hemorrhage model. We completely agree with them that their work, which is in complete agreement with ours, yet published earlier, merits being cited in our article, and we therefore were wrong to say, “There are no experimental or clinical studies investigating the effects of intraarterial nimodipine infusion.” However, their article was published at approximately the same time that we submitted our manuscript for publication (our very first correspondence was initiated on June 1, 2004), and it was undeniably, but surely inadvertently, omitted. Neither we nor the reviewers were able to catch that missing citation in the process of publication. We take this opportunity to present our apologies to the authors. Nevertheless, we also want to point out that a preliminary account of this study was already presented in The Fourth Asian-Oceanian Congress of Neuroradiology and Head & Neck Radiology in Parallel with the Sixth Congress of World Federation of Interventional and Therapeutic Neuroradiology, which was held in Seoul, Korea, on September 21–25, 2001.¹ Publication delay was due to a reshuffling of our research group in the course of the study.

We believe that animal experimentation plays a key role in the development of new therapeutic modalities with the ease of performing controlled experiments and with the option to test both current and investigational drugs. In this respect, it is of value to note that the vehicle injections showed no reversal of the vasospasm in our rabbit model, a point of concern raised by Biondi et al regarding the alcohol content of the product (nimodipine, Nimotop) used in the clinical study.