Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleBRAIN

Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia

L.I. Wallis, P.D. Griffiths, S.J. Ritchie, C.A.J. Romanowski, G. Darwent and I.D. Wilkinson
American Journal of Neuroradiology January 2007, 28 (1) 79-83;
L.I. Wallis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.D. Griffiths
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.J. Ritchie
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.A.J. Romanowski
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Darwent
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I.D. Wilkinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Gatti RA, Berkel I, Boder E, et al. Localization of an ataxia-telangiectasia gene to chromosome 11q22–23. Nature 1998;336:577–78
  2. Lange E, Borresen AL, Chen X, et al. Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium. Am J Hum Genet 1995;57:112–19
    PubMed
  3. ↵
    Savitsky K, Bar-Shira A, Gilad S, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 1995;268:1749–53
    Abstract/FREE Full Text
  4. ↵
    Olsen JH, Hahnemann JM, Børresen-Dale A-L, et al. Cancer in patients with ataxia-telangiectasia and in their relatives in the Nordic countries. J Natl Cancer Inst 2001;93:121–27
    Abstract/FREE Full Text
  5. ↵
    Jabado N, Concannon P, Gatti RA. Ataxia-telangiectasia, a neurodegenerative disorder. In: T Klockgether, ed. Handbook of Ataxia Disorders. New York: Marcel Dekker;2000 :163–90
  6. ↵
    Lederman HM, Crawford TO (2002) Handbook for families and caregivers. In: A-T Children’s Project [online]. Available at: http://www.atcp.org/Handbook%20TOC.htm. Accessed January 2006
  7. ↵
    Farr AK, Shalev B, Crawford TO, et al. Ocular manifestations of ataxia-telangiectasia. Am J Ophthalmol 2002;134:891–95
    CrossRefPubMedWeb of Science
  8. ↵
    Solitaire GB. Louis-Bar’s syndrome (ataxia-telangiectasia). Neurology 1968;18:1180–86
    FREE Full Text
  9. Nowak-Wegryzn A, Crawford TO, Winkelstein JA, et al. Immunodeficiency and infections in ataxia-telangiectasia. J Pediatr 2003;144:505–11
  10. ↵
    Woods CG, Taylor AM. Ataxia telangiectasia in the British Isles: the clinical and laboratory features of 70 affected individuals. Q J Med 1992;82:169–79
    Abstract/FREE Full Text
  11. ↵
    Taylor AM, Metcalfe JA, Thick J, et al. Leukemia and lymphoma in ataxia telangiectasia. Blood 1996;87:423–38
    Abstract/FREE Full Text
  12. ↵
    Shiloh Y. Ataxia telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu Rev Genet 1997;31:635–62
    CrossRefPubMedWeb of Science
  13. ↵
    Osborne AG, ed. Diagnostic Neuroradiology. St. Louis: Mosby-Year Book;1994 :309–11
  14. ↵
    Vanhamme L, van den Boogaart A, van Huffel S. Improved methods for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997;129:35–43
    CrossRefPubMedWeb of Science
  15. ↵
    de Beer R, van Ormondt D. Analysis of NMR data using time domain fitting procedures. In: Rudin M, ed. NMR Basic Principles and Progress. Vol26 . Berlin: Springer-Verlag;1992 :201–48
  16. ↵
    Perlman S, Becker-Catalina S, Gatti R. Ataxia-telangiectasia: diagnosis and treatment. Semin Pediatr Neurol 2003;10:173–82
    CrossRefPubMed
  17. ↵
    Gatti RA, Vinters HV. Cerebellar pathology in ataxia-telangiectasia: the significance of basket cells. Kroc Found Ser 1985;19:225–32
    PubMed
  18. ↵
    Demaerel PH, Kendall BE, Kingsley D. Cranial CT and MRI in diseases with DNA repair defects. Neuroradiology 1992;34:117–21
    CrossRefPubMed
  19. ↵
    Farina L, Uggetti C, Ottolini A, et al. Ataxia-telangiectasia: MR and CT findings. J Comput Assist Tomogr 1994;18:724–27
    CrossRefPubMedWeb of Science
  20. ↵
    Sardanelli F, Parodi RC, Ottonello C, et al. Cranial MRI in ataxia-telangiectasia. Neuroradiology 1995;37:77–82
    CrossRefPubMedWeb of Science
  21. ↵
    Tavani F, Zimmerman RA, Berry GT, et al. Ataxia-telangiectasia: the pattern of cerebellar atrophy on MRI. Neuroradiology 2003;45:315–19
    PubMedWeb of Science
  22. ↵
    Barr RM, Dillon WP, Wilson CB. Slow-flow vascular malformations of the pons: capillary telangiectasias? AJNR Am J Neuroradiol 1996;17:71–78
    Abstract
  23. ↵
    Lee RR, Becher MW, Benson ML, et al. Brain capillary telangiectasia: MR imaging appearance and clinicohistopathologic findings. Neuroradiology 1997;205:797–805
  24. ↵
    Ciemins JJ, Horowitz AL. Abnormal white matter signal in ataxia-telangiectasia. AJNR Am J Neuroradiol 2000;21:1483–85
    Abstract/FREE Full Text
  25. ↵
    Huddle DC, Chaloupka JC, Sehgal V. Clinically aggressive diffuse capillary telangiectasia of the brain stem: a clinical radiologic-pathologic case study. AJNR Am J Neuroradiol 1999;20:1674–77
    Abstract/FREE Full Text
  26. ↵
    Wilkinson ID, Paley M, Chong WK, et al. Proton spectroscopy in HIV infection: relaxation times of cerebral metabolites. Magn Res Imag 1994;12:951–57
  27. ↵
    Viau M, Boulanger Y. Characterization of ataxias with magnetic resonance imaging and spectroscopy. Parkinsonism Relat Disord 2004;10:335–51
    CrossRefPubMedWeb of Science
  28. ↵
    Guerrini L, Lolli F, Ginestroni A, et al. Brainstem degeneration correlates with clinical dysfunction in SCA1 but not SCA2. A qualitative volumetric, diffusion and proton spectroscopic MR study. Brain 2004;127:1785–95
    Abstract/FREE Full Text
  29. ↵
    Wilkinson ID, Hadjivassiliou M, Dickson JM, et al. Cerebellar abnormalities on proton MR spectroscopy in gluten ataxia. J Neurol Neurosurg Psychiatry 2005;76:1011–13
    Abstract/FREE Full Text
  30. ↵
    Mascalchi M, Cosottini M, Lolli F, et al. Proton MR spectroscopy of the cerebellum and pons in patients with degenerative ataxia. Radiology 2002;223:371–78
    CrossRefPubMedWeb of Science
  31. ↵
    Castillo M, Kwock L, Mukherji SK. Clinical applications of proton MR spectroscopy. AJNR Am J Neuroradiol 1996;17:1–15
    PubMed
  32. ↵
    Ross B, Bluml S. Magnetic resonance spectroscopy of the human brain. Anat Rec 2001;265:54–84
    CrossRefPubMed
  33. ↵
    Perry TL, Kish SJ, Hinton D, et al. Neurochemical abnormalities in a patient with ataxia-telangiectasia. Neurology 1984;34:187–91
    Abstract/FREE Full Text
  34. ↵
    Soher BJ, van Zijl PC, Duyn JH, et al. Quantitative proton MR spectroscopic imaging of the human brain. Magn Res Med 1996;35:356–63
    PubMedWeb of Science
  35. ↵
    Burtscher IM, Holtås S. Proton MR spectroscopy in clinical routine. J Magn Res Imag 2001;13:560–67
    CrossRefPubMed
  36. ↵
    Larnaout A, Belal S, Ben Hamida C, et al. Atypical ataxia telangiectasias with early childhood lower motor neuron degeneration: a clinicopathological observation in three siblings. J Neurol 1998;245:231–35
    PubMed
  37. ↵
    Paula-Barbosa MM, Ruela C, Tavares MA, et al. Cerebellar cortex ultrastructure in ataxia-telangiectasia. Ann Neurol 1983;13:297–302
    CrossRefPubMedWeb of Science
  38. ↵
    Gill SS, Small RK, Thomas DG, et al. Brain metabolites as 1H NMR markers of neuronal and glial disorders. NMR Biomed 1989;2:196–200
    PubMed
  39. ↵
    Lai PH, Chen PC, Chang MH, et al. In vivo proton MR spectroscopy of chorea-ballismus in diabetes mellitus. Neuroradiology 2001;43:525–31
    CrossRefPubMed
  40. ↵
    Scarabino T, Popolizio T, Bertolino A, et al. Proton magnetic resonance spectroscopy of the brain in pediatric patients. Eur J Radiol 1999;30:142–53
    CrossRefPubMed
  41. ↵
    Wilson JX. Antioxidant defense of the brain: a role for astrocytes. Can J Physiol Pharmacol 1997;75:1149–63
    CrossRefPubMedWeb of Science
  42. ↵
    Iida T, Furuta A, Nakabeppu Y, et al. Defense mechanism to oxidative DNA damage in glial cells. Neuropathology 2004;24:125–30
    PubMed
  43. ↵
    Rotman G, Shiloh Y. ATM: from gene to function. Hum Mol Genet 1998;7:1555–63
    Abstract/FREE Full Text
  44. ↵
    Watters DJ. Oxidative stress in ataxia-telangiectasia. Redox Rep 2002;8:23–29
    PubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 28 (1)
American Journal of Neuroradiology
Vol. 28, Issue 1
January 2007
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
L.I. Wallis, P.D. Griffiths, S.J. Ritchie, C.A.J. Romanowski, G. Darwent, I.D. Wilkinson
Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia
American Journal of Neuroradiology Jan 2007, 28 (1) 79-83;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia
L.I. Wallis, P.D. Griffiths, S.J. Ritchie, C.A.J. Romanowski, G. Darwent, I.D. Wilkinson
American Journal of Neuroradiology Jan 2007, 28 (1) 79-83;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • A novel, ataxic mouse model of Ataxia Telangiectasia caused by a clinically relevant nonsense mutation
  • Single-nucleus transcriptomic analyses reveal microglial activation underlying cerebellar degeneration in Ataxia Telangiectasia
  • Accumulation of Brain Hypointense Foci on Susceptibility-Weighted Imaging in Childhood Ataxia Telangiectasia
  • Cerebral Abnormalities in Adults with Ataxia-Telangiectasia
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Progression of Microstructural Damage in Spinocerebellar Ataxia Type 2: A Longitudinal DTI Study
  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire