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Research ArticleBRAIN

Relevance of Common Carotid Intima-Media Thickness and Carotid Plaque as Risk Factors for Ischemic Stroke in Patients with Type 2 Diabetes Mellitus

E.J. Lee, H.J. Kim, J.M. Bae, J.C. Kim, H.J. Han, C.S. Park, N.H. Park, M.S. Kim and J.A. Ryu
American Journal of Neuroradiology May 2007, 28 (5) 916-919;
E.J. Lee
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H.J. Kim
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J.M. Bae
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J.C. Kim
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H.J. Han
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C.S. Park
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N.H. Park
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M.S. Kim
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J.A. Ryu
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    Fig 1.

    Longitudinal scan of carotid ultrasonogram. Measurement of CCA-IMT (large arrows) at the far wall of the common carotid artery is shown. The carotid plaque (small arrows) in the distal common carotid artery is seen. The arrowhead represents carotid bifurcation.

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    Table 1:

    Clinical characteristics of case and control subjects with type 2 diabetes

    Control Subjects (89)Case Subjects (44)P
    Age, years62.2 ± 10.664.0 ± 9.3.33
    Male sex55.8%44.2%.03
    Smoking (Y)11.1%34.7%.02
    Hypertension (Y)51.2%70.7%.03
    HDL-C (>40 mmol/L)62.5%30.9%.001
    LDL-C (>130 mmol/L)41.6%27.3%.32
    Triglyceride, mmol/L195.9 ± 46.5187.5 ± 42.2.14
    BMI, kg/m225.9 ± 3.4924.6 ± 2.79.32
    HbA1c > 7, %72.9%69.1%.65
    IHD (Y)12.1%12.5%1.00
    • Note:—Y indicates yes; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; BMI, body mass index; Hb, hemoglobin; IHD, ischemic heart disease. Continuous data are presented as mean ± SD, noncontinuous data as percentages.

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    Table 2:

    IMT and plaque score in case and control subjects

    Control Subjects (89)Case Subjects (44)P
    Log mean IMT (m (sd))−0.186 (0.23)−0.098 (0.22).04
    Log max IMT (m (sd))−0.043 (0.27)0.067 (0.27).03
    Plaque score
        045.5%21.4%<.001
        1–350.0%26.1%
        4–64.5%26.1%
    • Note:—IMT indicates intima-media thickness.

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    Table 3:

    Association between CCA-IMT and plaque score and ischemic stroke on multiple logistic regression analysis

    Odds Ratio95% CI
    LowerUpper
    Log (mean IMT)
        Crude5.291.0526.7
        Adjusted*1.640.1419.4
    Log (max. IMT)
        Crude4.581.1618.1
        Adjusted*2.080.2418.1
    Plaque score
        Crude3.141.675.93
        Adjusted*2.140.805.73
    • Note:—CCA-IMT indicates common carotid artery intima-media thickness; CI, confidence interval.

    • * Adjusted for sex, smoking habit, high-density lipoprotein, and hypertension history

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American Journal of Neuroradiology: 28 (5)
American Journal of Neuroradiology
Vol. 28, Issue 5
May 2007
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E.J. Lee, H.J. Kim, J.M. Bae, J.C. Kim, H.J. Han, C.S. Park, N.H. Park, M.S. Kim, J.A. Ryu
Relevance of Common Carotid Intima-Media Thickness and Carotid Plaque as Risk Factors for Ischemic Stroke in Patients with Type 2 Diabetes Mellitus
American Journal of Neuroradiology May 2007, 28 (5) 916-919;

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Relevance of Common Carotid Intima-Media Thickness and Carotid Plaque as Risk Factors for Ischemic Stroke in Patients with Type 2 Diabetes Mellitus
E.J. Lee, H.J. Kim, J.M. Bae, J.C. Kim, H.J. Han, C.S. Park, N.H. Park, M.S. Kim, J.A. Ryu
American Journal of Neuroradiology May 2007, 28 (5) 916-919;
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