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An Experimental Study of Acute Radiation-Induced Cognitive Dysfunction in a Young Rat Model

Y. Liu, S. Xiao, J. Liu, H. Zhou, Z. Liu, Y. Xin and W.Z. Suo
American Journal of Neuroradiology February 2010, 31 (2) 383-387; DOI: https://doi.org/10.3174/ajnr.A1801
Y. Liu
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S. Xiao
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J. Liu
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H. Zhou
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Z. Liu
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Y. Xin
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W.Z. Suo
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    Fig 1.

    Effects of brain irradiation on place navigation function of rats in water maze. Rats exposed to different doses of irradiation treatments were subjected to the Morris water maze test. The latency of target finding (A) and swimming distance (B) was plotted and shown as indicated. * P < .05, ** P < .01, compared with their corresponding sham.

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    Fig 2.

    Effects of brain irradiation on space probe function of rats in the water maze. Rats exposed to different doses of irradiation treatments were subjected to the Morris water maze test. The journey distance of target to total (A) and target quadrant staying time (B) were plotted and shown as indicated. * P < .05, ** P < .01, compared with their corresponding sham.

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    Fig 3.

    Effects of brain irradiation on brain water content and BBB permeability. A, Water content of brain, determined by the method of dry and wet weight. Water content in brain = (wet weight−dry weight)/wet weight × 100%. B, BBB permeability was expressed as micrograms of EB per milligrams of brain tissue (μg/g). * P < .05, ** P < .01, # P < .001, compared with their corresponding sham.

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    Fig 4.

    Pathologic change after irradiation. A and B represent the results of HE staining in the control group (A) and the 40-Gy irradiated group 20 days after irradiation (B). It was noted that the partial loose and irregular arrangement of neurons and vacular degeneration in the parietal white matter near the cortex were found in the 40-Gy irradiated group 20 days after irradiation. Scale bar, 40 μmol/L.

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American Journal of Neuroradiology: 31 (2)
American Journal of Neuroradiology
Vol. 31, Issue 2
1 Feb 2010
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Cite this article
Y. Liu, S. Xiao, J. Liu, H. Zhou, Z. Liu, Y. Xin, W.Z. Suo
An Experimental Study of Acute Radiation-Induced Cognitive Dysfunction in a Young Rat Model
American Journal of Neuroradiology Feb 2010, 31 (2) 383-387; DOI: 10.3174/ajnr.A1801

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An Experimental Study of Acute Radiation-Induced Cognitive Dysfunction in a Young Rat Model
Y. Liu, S. Xiao, J. Liu, H. Zhou, Z. Liu, Y. Xin, W.Z. Suo
American Journal of Neuroradiology Feb 2010, 31 (2) 383-387; DOI: 10.3174/ajnr.A1801
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