Article Figures & Data
Figures
- Fig 1.
A−C, DTI maps of the central section of the ON. The regions of interest are placed on the b=0 averaged images, which are defined in the coronal map (A) and adjusted in the sagittal (B) and axial (C) images obtained by using multiplanar reconstruction. D−G, Then the regions of interest are transferred onto the ADC (D), FA (E), λ‖ (F), and λ⊥ (G) maps.
- Fig 2.
Bar graphs of the ADC, FA, principal eigenvalue λ‖, and the orthogonal eigenvalues λ⊥ averaged across the affected and unaffected contralateral ONs of 26 patients with ION compared with normal ONs of 15 controls. The error bars denote the SDs across subjects. The units of the ADC, λ‖, and λ⊥ measures are in ×10−3 square millimeters per second −1. The asterisk indicates a significant difference compared with the affected nerves of patients. There is no significant difference between unaffected ONs of patients and ONs of controls in all DTI measures.
- Fig 3.
Plot of ADC (A) and the orthogonal eigenvalue λ⊥ (B) versus whole-field VEP amplitude averaged across the pixels inside the regions of interest along the affected ONs of 26 patients with ischemic ION, respectively.
Tables
Mean SD Range Ratio Male/female – – – 14:12 Age (yr) 53.23 9.53 27–69 – Timeb 20.65 8.84 6–30 – Standard logarithmic visual acuity Affected 0.22 0.21 0.01–0.80 – Not affected 0.97 0.16 0.6–1.2 – Visual field mean deviation (dB) Affected 22.98 5.95 10.93–32 – Not affected 1.72 1.87 0.10–7.70 – -
a —indicates patients with AION.
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b Since onset of AION (days).
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Mean SD Range Ratio Male/female 8:7 Age (yr) 50 8.23 30–58 Standard logarithmic visual acuity, selected 1.12 0.11 0.8–1.4 Visual field mean deviation (dB), selected 1.56 1.22 0.1–6.2 FAb,c ADC (×10−6 mm2s−1)b,c λ‖(×10−6 mm2s−1) λ⊥(×10−6 mm2s−1)b,c Whole-Field VEP Amplitude (μV)b,c Whole-Field VEP Latency (ms)b,c Patients' affected nerves (n = 26) 0.283 ± 0.073 1429 ± 198 1786 ± 159 1245 ± 172 4.53 ± 1.17 132.7 ± 17.48 Patients' unaffected nerves (n = 26) 0.569 ± 0.046 1028 ± 146 1720 ± 199 746 ± 78 9.67 ± 2.52 94.86 ± 9.07 Control nerves (n = 15) 0.587 ± 0.023 1008 ± 111 1702 ± 199 729 ± 130 9.40 ± 3.03 97.77 ± 4.62 -
a The values are mean ± SD.
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b Significant difference between nerves of controls and affected nerves of patients.
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c Significant difference between unaffected contralateral nerves and affected nerves in patients. There is no significant difference between unaffected ONs of patients and ONs of controls in all DTI measures.
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