Prediction of Locoregional Control in Head and Neck Squamous Cell Carcinoma with Serial CT Perfusion during Radiotherapy

Article Figures & Data

Table 1:

Patient and tumor characteristics of 15 patients with HNSCC undergoing serial CTP imaging during RT

Age (yr)	Sex	Primary Site	T	N	Overall Stage
46	M	Base of tongue	2	2c	IVa
68	M	L auricle	2	0	II
60	M	Oral tongue	4a	3	IVb
54	M	L tonsil	2	2c	IVa
59	F	Base of tongue	4a	2b	IVa
63	M	Nasopharynx	2	2	III
65	M	Larynx	2	0	II
63	M	Larynx	4a	0	IVa
45	M	Nasopharynx	4	1	IVa
48	F	L tonsil	2	2b	IVa
46	M	Nasopharynx	3	2c	IVa
57	M	R tonsil	2	2c	IVa
55	F	Larynx	3	0	III
61	M	L hypopharynx	3	0	III
50	M	Unknown primary	0	2b	IVa

Table 2:

Mean tumor perfusion parameters for the whole patient cohort before, during, and after RT^a

Parameter (mean value)	Baseline Prior to RT(n = 15)	During RT			6 Weeks Post-RT(n = 12)
Parameter (mean value)	Baseline Prior to RT(n = 15)	Week 2(n = 15)	Week 4(n = 14)	Week 6(n = 11)	6 Weeks Post-RT(n = 12)
BF (mL/100 g/min)	109.4 (65.3)	123.5 (73.7)	109.6 (94.6)	126.7 (146.0)	64.3 (54.3)
BV (mL/100 g)	5.5 (1.9)	5.8 (2.5)	4.9 (2.8)	5.9 (4.8)	3.9 (2.8)
MTT (s)	5.1 (2.5)	4.8 (2.4)	4.9 (4.4)	4.9 (2.4)	6.0 (2.5)
CP (mL/100 g/min)	15.4 (9.2)	20.0 (8.9)	20.5 (13.4)	10.6 (7.9)	14.6 (8.8)

Table 3:

Tumor perfusion parameters by LRC status, before, during, and after RT^a

Parameter	Locoregional Status	Baseline Prior to RT, LRF (n = 2); LRC (n = 13)	During RT (SD)			6 Weeks Post-RT, LRF (n = 2); LRC (n = 10)
Parameter	Locoregional Status	Baseline Prior to RT, LRF (n = 2); LRC (n = 13)	Week 2, LRF (n = 2); LRC (n = 13)	Week 4, LRF (n = 2); LRC (n = 12)	Week 6, LRF (n = 1); LRC (n = 10)	6 Weeks Post-RT, LRF (n = 2); LRC (n = 10)
BF (mL/100 g/min)	LRF	53.4 (1.8)	43.9 (9.9)	217.7 (243.8)	16.2 (NA)	28.4 (20.8)
	LRC	118.0 (66.1)	135.8 (71.5)	91.6 (51.9)	137.8 (149.0)	71.5 (56.6)
P value		.004	.0008	.598	NA	.122
BV (ml/100 g)	LRF	4.5 (1.9)	3.6 (1.1)	6.7 (6.2)	2.3 (NA)	3.2 (3.1)
	LRC	5.6 (2.0)	6.1 (2.5)	4.6 (2.2)	6.2 (4.9)	4.0 (2.8)
P value		.546	.081	.721	NA	.766
MTT (s)	LRF	6.4 (2.0)	7.2 (2.8)	3.5 (1.8)	11.1 (NA)	7.8 (2.2)
	LRC	4.9 (2.6)	4.4 (2.2)	5.1 (4.7)	4.2 (1.3)	5.7 (2.5)
P value		.461	.379	.438	NA	.381
CP (mL/100 g/min)	LRF	7.7 (2.3)	6.6 (5.6)	29.5 (28.5)	4.4 (NA)	9.9 (9.2)
	LRC	16.6 (9.3)	22.0 (7.5)	19.0 (11.1)	11.3 (8.1)	15.6 (8.9)
P value		.02	.098	.694	NA	.537

a Data are presented as a mean ± SD. P values are calculated from an independent samples t test comparing mean CTP parameter values in the LRC versus LRF groups. CTP parameters were not measured at week 6 in 1 of the 2 patients with LRF; these are indicated by NA.