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Clinical Semiology and Neuroradiologic Correlates of Acute Hypernatremic Osmotic Challenge in Adults: A Literature Review

F.Y. Ismail, A. Szóllics, M. Szólics, N. Nagelkerke and M. Ljubisavljevic
American Journal of Neuroradiology December 2013, 34 (12) 2225-2232; DOI: https://doi.org/10.3174/ajnr.A3392
F.Y. Ismail
aFrom the Departments of Pediatrics (F.Y.I.)
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A. Szóllics
dDepartment of Radiology (A.S.), Kálmán Pándy Békes County Hospital, Gyula, Hungary
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M. Szólics
eDivision of Neurology (M.S.), Department of Medicine, Tawam Hospital, Al Ain, Abu-Dhabi, UAE.
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N. Nagelkerke
cInstitute of Public Health (N.N.), College of Medicine and Health Sciences, United Arab Emirates (UAE) University, Al Ain, UAE
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M. Ljubisavljevic
bPhysiology (M.L.)
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REFERENCES

  1. 1.↵
    1. Adams RD,
    2. Victor M,
    3. Mancall EL
    . Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. AMA Arch Neurol Psychiatry 1959;81:154–72
    CrossRefPubMed
  2. 2.↵
    1. McComb RD,
    2. Pfeiffer RF,
    3. Casey JH,
    4. et al
    . Lateral pontine and extrapontine myelinolysis associated with hypernatremia and hyperglycemia. Clin Neuropathol 1989;8:284–88
    PubMedWeb of Science
  3. 3.↵
    1. Kuwahara H
    . Central pontine myelinolysis associated with pancreatic diabetes. J Neurol 2012;259:353–54
    CrossRefPubMed
  4. 4.↵
    1. Lou F
    . A good prognosis of central pontine myelinolysis in a type 2 diabetic patient. Ann Acad Med Singapore 2011;40:384–86
    PubMed
  5. 5.↵
    1. Akyol A
    . Association of central pontine myelinolysis and extra-pontine myelinolysis in diabetic patient. Neuro Endocrinol Lett 2007;28:252–54
    PubMed
  6. 6.↵
    1. Morales-Buenrostro LE,
    2. Tellez-Zenteno JF,
    3. Posadas-Calleja JG,
    4. et al
    . Pontine myelinolysis after a hypoglycemic episode [in Spanish]. Rev Invest Clin 2002;54:181–84
    PubMed
  7. 7.↵
    1. Rajbhandari SM,
    2. Powell T,
    3. Davies-Jones GA
    . Central pontine myelinolysis and ataxia: an unusual manifestation of hypoglycaemia. Diabet Med 1998;15:259–61
    CrossRefPubMed
  8. 8.↵
    1. Kilinç M,
    2. Benli US,
    3. Can U
    . Osmotic myelinolysis in a normonatremic patient. Acta Neurol Belg 2002;102:87–89
    PubMed
  9. 9.↵
    1. Clark WR
    . Diffuse demyelinating lesions of the brain after the rapid development of hypernatremia. West J Med 1992;157:571–73
    PubMed
  10. 10.↵
    1. Verbalis JG
    . Brain volume regulation in response to changes in osmolality. Neuroscience 2010;168:862–70
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Gage TP,
    2. Vivian G
    . Hypernatremia after hypertonic saline irrigation of an hepatic hydatid cyst. Ann Intern Med 1984;101:405
    PubMed
  12. 12.↵
    1. Albi A,
    2. Baudin F,
    3. Matmar M,
    4. et al
    . Severe hypernatremia after hypertonic saline irrigation of hydatid cysts. Anesth Analg 2002;95:1806–08, table of contents
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Machino T,
    2. Machino T,
    3. Yoshizawa T
    . Brain shrinkage due to acute hypernatremia. Neurology 2006;67:880
    CrossRef
  14. 14.↵
    1. Go M,
    2. Amino A,
    3. Shindo K,
    4. et al
    . A case of central pontine myelinolysis and extrapontine myelinolysis during rapid correction of hypernatremia [in Japanese]. Rinsho Shinkeigaku 1994;34:1130–35
    PubMed
  15. 15.
    1. Wacks I,
    2. Oster JR,
    3. Roth D,
    4. et al
    . Severe cerebral edema in a patient with anasarca and hypernatremia. Clin Nephrol 1992;37:19–22
    PubMedWeb of Science
  16. 16.
    1. Konno S,
    2. Nakagawa T,
    3. Yoshida T,
    4. et al
    . A case report of central pontine myelinolysis associated with serum hyperosmolality after open heart surgery [in Japanese]. Kyobu Geka 1993;46:150–54
    PubMed
  17. 17.
    1. Dobato JL,
    2. Barriga FJ,
    3. Pareja JA,
    4. et al
    . Extrapontine myelinolyses caused by iatrogenic hypernatremia following rupture of a hydatid cyst of the liver with an amnesic syndrome as sequela [in Spanish]. Rev Neurol 2000;31:1033–35
    PubMedWeb of Science
  18. 18.
    1. Chua GC,
    2. Chua GC,
    3. Sitoh YY,
    4. et al
    . MRI findings in osmotic myelinolysis. Clin Radiol 2002;57:800–06
    CrossRefPubMed
  19. 19.
    1. Kamijo Y,
    2. Soma K,
    3. Hamanaka S,
    4. et al
    . Dural sinus thrombosis with severe hypernatremia developing in a patient on long-term lithium therapy. Clinical Toxicology 2003;41:359–62
    CrossRef
  20. 20.
    1. van der Helm-van Mil AH,
    2. van Vugt JP,
    3. Lammers GJ,
    4. et al
    . Hypernatremia from a hunger strike as a cause of osmotic myelinolysis. Neurology 2005;64:574–75
    CrossRef
  21. 21.
    1. Al-Sarraf AJ,
    2. Haque M,
    3. Pudek M,
    4. et al
    . Central pontine myelinolysis after orthotopic liver transplant: a rare complication. Exp Clin Transplant 2010;8:321–24
    PubMed
  22. 22.
    1. Lee IW,
    2. Su MT,
    3. Kuo PL,
    4. et al
    . Gestational diabetes and central pontine myelinolysis with quadriplegia: a case report. J Matern Fetal Neonatal Med 2010;23:728–31
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Szolics M,
    2. Ljubisavljevic M,
    3. Samir HA,
    4. et al
    . Extrapontine myelinolysis and cortical laminar necrosis caused by severe hypernatremia following peritoneal lavage for ruptured hydatid cyst of the liver: a case report and review of the literature. The Neuroradiology Journal 2010;1:325–31
  24. 24.↵
    1. Cagnin A,
    2. Manara R,
    3. Piron L,
    4. et al
    . Hypernatremia-induced limbic system damage. Anesthesiology 2011;114:175
    CrossRefPubMed
  25. 25.
    1. Odier C,
    2. Nguyen DK,
    3. Panisset M,
    4. et al
    . Central pontine and extrapontine myelinolysis: from epileptic and other manifestations to cognitive prognosis. J Neurol 2010;257:1176–80
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Chang L,
    2. Harrington DW,
    3. Milkotic A,
    4. et al
    . Unusual occurrence of extrapontine myelinolysis associated with acute severe hypernatraemia caused by central diabetes insipidus. Clin Endocrinol (Oxf) 2005;63:233–35
    CrossRefPubMed
  27. 27.↵
    1. Kawahara I,
    2. Tokunaga Y,
    3. Ishizaka S,
    4. et al
    . Reversible clinical and magnetic resonance imaging of central pontine myelinolysis following surgery for craniopharyngioma: serial magnetic resonance imaging studies. Neurol Med Chir (Tokyo) 2009;49:120–23
    CrossRefPubMed
  28. 28.
    1. Vin-Christian K,
    2. Arieff AI
    . Diabetes insipidus, massive polyuria, and hypernatremia leading to permanent brain damage. Am J Med 1993;94:341–42
    CrossRefPubMed
  29. 29.
    1. Kendall R,
    2. Lafuente J,
    3. Hosie KB
    . Central pontine myelinolysis after an operation. J R Soc Med 1997;90:445–46
    Abstract/FREE Full Text
  30. 30.↵
    1. Naik KR,
    2. Saroja AO
    . Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis and rhabdomyolysis. J Neurol Sci 2010;291:5–11
    CrossRefPubMed
  31. 31.↵
    1. Riggs JE
    . Neurologic manifestations of electrolyte disturbances. Neurol Clin 2002;20:227–39, vii
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Adrogué HJ,
    2. Madias NE
    . Hypernatremia. N Engl J Med 2000;342:1493–99
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Kallakatta RN,
    2. Radhakrishnan A,
    3. Fayaz RK,
    4. et al
    . Clinical and functional outcome and factors predicting prognosis in osmotic demyelination syndrome (central pontine and/or extrapontine myelinolysis) in 25 patients. J Neurol Neurosurg Psychiatry 2011;82:326–31
    Abstract/FREE Full Text
  34. 34.↵
    1. Menger H
    . Outcome of central pontine and extrapontine myelinolysis (n = 44). J Neurol 1999;246:700–05
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Brunner JE,
    2. Redmond JM,
    3. Haggar AM,
    4. et al
    . Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. Ann Neurol 1990;27:61–66
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Davenport C,
    2. Liew A,
    3. Vic Lau P
    . Central pontine myelinolysis secondary to hypokalaemic nephrogenic diabetes insipidus. Ann Clin Biochem 2010;47:86–89
    Abstract/FREE Full Text
  37. 37.↵
    1. Strange K
    . Regulation of solute and water balance and cell volume in the central nervous system. J Am Soc Nephrol 1992;3:12–27
    Abstract
  38. 38.↵
    1. De Petris L,
    2. Luchetti A,
    3. Emma F
    . Cell volume regulation and transport mechanisms across the blood-brain barrier: implications for the management of hypernatraemic states. Eur J Pediatr 2001;160:71–77
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Holliday MA,
    2. Kalayci MN,
    3. Harrah J,
    4. et al
    . Factors that limit brain volume changes in response to acute and sustained hyper- and hyponatremia. J Clin Invest 1968;47:1916–28
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Cserr HF,
    2. DePasquale M,
    3. Nicholson C,
    4. et al
    . Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. J Physiol 1991;442:277–95
    CrossRefPubMedWeb of Science
  41. 41.↵
    1. Arieff AI
    . Central nervous system manifestations of disordered sodium metabolism. Clin Endocrinol Metab 1984;13:269–94
    CrossRefPubMedWeb of Science
  42. 42.↵
    1. Rippe DJ,
    2. Edwards MK,
    3. D'Amour PG,
    4. et al
    . MR imaging of central pontine myelinolysis. J Comput Assist Tomogr 1987;11:724–26
    CrossRefPubMedWeb of Science
  43. 43.↵
    1. Bekiesińska-Figatowska M,
    2. Bulski T,
    3. Rózyczka I,
    4. et al
    . MR imaging of seven presumed cases of central pontine and extrapontine myelinolysis. Acta Neurobiol Exp (Wars) 2001;61:141–44
    PubMed
  44. 44.↵
    1. Clifford DB,
    2. Gado MH,
    3. Levy BK
    . Osmotic demyelination syndrome: lack of pathologic and radiologic imaging correlation. Arch Neurol 1989;46:343–47
    CrossRefPubMed
  45. 45.↵
    1. Graff-Radford J,
    2. Fugate JE,
    3. Kaufmann TJ,
    4. et al
    . Clinical and radiologic correlations of central pontine myelinolysis syndrome. Mayo Clin Proc 2011;86:1063–67
    CrossRefPubMedWeb of Science
  46. 46.↵
    1. Thompson PD,
    2. Miller D,
    3. Gledhill RF,
    4. et al
    . Magnetic resonance imaging in central pontine myelinolysis. J Neurol Neurosurg Psychiatry 1989;52:675–77
    Abstract/FREE Full Text
  47. 47.↵
    1. Ardizzone G,
    2. Arrigo A,
    3. Schellino MM,
    4. et al
    . Neurological complications of liver cirrhosis and orthotopic liver transplant. Transplant Proc 2006;38:789–92
    CrossRefPubMed
  48. 48.↵
    1. Ardizzone G,
    2. Arrigo A,
    3. Panaro F,
    4. et al
    . Cerebral hemodynamic and metabolic changes in patients with fulminant hepatic failure during liver transplantation. Transplant Proc 2004;36:3060–64
    CrossRefPubMed
  49. 49.↵
    1. Goldman MB,
    2. Torres IJ,
    3. Keedy S,
    4. et al
    . Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients. Hippocampus 2007;17:554–62
    CrossRefPubMedWeb of Science
  50. 50.↵
    1. Fotuhi M,
    2. Do D,
    3. Jack C
    . Modifiable factors that alter the size of the hippocampus with ageing. Nat Rev Neurol 2012;8:189–202
    CrossRefPubMed
  51. 51.↵
    1. Vexler ZS,
    2. Ayus JC,
    3. Roberts TP,
    4. et al
    . Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J Clin Invest 1994;93:256–64
    CrossRefPubMedWeb of Science
  52. 52.↵
    1. Dervisoglu E,
    2. Yegenaga I,
    3. Anik Y,
    4. et al
    . Diffusion magnetic resonance imaging may provide prognostic information in osmotic demyelination syndrome: report of a case. Acta Radiol 2006;47:208–12
    FREE Full Text
  53. 53.↵
    1. Adler S,
    2. Verbalis JG,
    3. Meyers S,
    4. et al
    . Changes in cerebral blood flow and distribution associated with acute increases in plasma sodium and osmolality of chronic hyponatremic rats. Exp Neurol 2000;163:63–71
    CrossRefPubMed
  54. 54.↵
    1. Ke QH,
    2. Chen JH,
    3. Zheng SS,
    4. et al
    . Prevention of central pontine myelinolysis in rats by early treatment with dexamethasone [in Chinese]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2006;35:424–29
    PubMed
  55. 55.↵
    1. Sakamoto E,
    2. Hagiwara D,
    3. Morishita Y,
    4. et al
    . Complete recovery of central pontine myelinolysis by high dose pulse therapy with methylprednisolone [in Japanese]. Nihon Naika Gakkai Zasshi 2007;96:2291–93
    CrossRefPubMed
  56. 56.↵
    1. Cho AH,
    2. Choi CG,
    3. Lee SA
    . Cortical laminar necrosis associated with osmotic demyelination syndrome. J Clin Neurol 2005;1:174–76
    CrossRefPubMed
  57. 57.↵
    1. Niwa K,
    2. Matsushima K,
    3. Yamamoto M,
    4. et al
    . Morel's laminar necrosis like findings on MRI in a case of extra-pontine myelinolysis [in Japanese]. Rinsho Shinkeigaku 1991;31:327–30
    PubMed
  58. 58.↵
    1. Shoji M,
    2. Kimura T,
    3. Ota K,
    4. et al
    . Cortical laminar necrosis and central pontine myelinolysis in a patient with Sheehan syndrome and severe hyponatremia. Intern Med 1996;35:427–31
    CrossRefPubMed
  59. 59.↵
    1. Susa SD
    . Acute intermittent porphyria with central pontine myelinolysis and cortical laminar necrosis. Neuroradiology 1999;41:835–39
    CrossRefPubMedWeb of Science
  60. 60.↵
    1. Cho AH,
    2. Choi CG,
    3. Lee SA
    . Cortical laminar necrosis associated with osmotic demyelination syndrome. J Clin Neurol 2005;1:174–76
    CrossRefPubMed
  61. 61.↵
    1. Martin RJ
    . Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes. J Neurol Neurosurg Psychiatry 2004;75(suppl 3):iii22–28
    FREE Full Text
  62. 62.↵
    1. Shah B,
    2. Tobias JD
    . Osmotic demyelination and hypertonic dehydration in a 9-year-old girl: changes in cerebrospinal fluid myelin basic protein. J Intensive Care Med 2006;21:372–76
    Abstract/FREE Full Text
  63. 63.↵
    1. Mastrangelo S,
    2. Arlotta A,
    3. Cefalo MG,
    4. et al
    . Central pontine and extrapontine myelinolysis in a pediatric patient following rapid correction of hypernatremia. Neuropediatrics 2009;40:144–47
    CrossRefPubMed
  64. 64.↵
    1. Ozdemir H,
    2. Kabakus N,
    3. Kurt AN,
    4. et al
    . Bilateral symmetrical hypodensities in the thalamus in a child with severe hypernatraemia. Pediatr Radiol 2005;35:449–50
    CrossRefPubMed
  65. 65.↵
    1. Achiwa S,
    2. Ando K,
    3. Ishikura R,
    4. et al
    . A case of extrapontine myelinolysis precipitated by correction of a hyper-osmolar state [in Japanese]. Nihon Igaku Hoshasen Gakkai Zasshi 2004;64:310–12
    PubMed
  66. 66.↵
    1. AlOrainy IA,
    2. O'Gorman AM,
    3. Decell MK
    . Cerebral bleeding, infarcts, and presumed extrapontine myelinolysis in hypernatraemic dehydration. Neuroradiology 1999;41:144–46
    CrossRefPubMed
  67. 67.↵
    1. Brown WD,
    2. Caruso JM
    . Extrapontine myelinolysis with involvement of the hippocampus in three children with severe hypernatremia. J Child Neurol 1999;14:428–33
    Abstract/FREE Full Text
  68. 68.↵
    1. Fahrbach J,
    2. Rozzelle CJ
    . Transient ventriculomegaly in a child presenting with hypernatremia: case report. J Neurosurg 2006;104 (3 suppl):192–94
    PubMed
  69. 69.↵
    1. Trachtman H,
    2. Yancey PH,
    3. Gullans SR
    . Cerebral cell volume regulation during hypernatremia in developing rats. Brain Res 1995;693:155–62
    CrossRefPubMedWeb of Science
  70. 70.↵
    1. Reulen HJ,
    2. Hase U,
    3. Fenske A,
    4. et al
    . Extracellular space and electrolyte distribution in grey and white matter of the dog brain [in German]. Acta Neurochir (Wien) 1970;22:305–25
    CrossRefPubMed
  71. 71.↵
    1. Lien YH,
    2. Shapiro JI,
    3. Chan L,
    4. et al
    . Effects of hypernatremia on organic brain osmoles. J Clin Invest 1990;85:1427–35
    CrossRefPubMedWeb of Science
  72. 72.↵
    1. Minami Y,
    2. Inoue K,
    3. Shimada S,
    4. et al
    . Rapid and transient up-regulation of Na+/myo-inositol cotransporter transcription in the brain of acute hypernatremic rats. Brain Res Mol Brain Res 1996;40:64–70
    CrossRefPubMed
  73. 73.↵
    1. Hijab S,
    2. Havalad S,
    3. Snyder AK
    . The role of organic osmolytes in the response of cultured astrocytes to hyperosmolarity. Am J Ther 2011;18:366–70
    CrossRefPubMed
  74. 74.↵
    1. Trachtman H
    . Cell volume regulation: a review of cerebral adaptive mechanisms and implications for clinical treatment of osmolal disturbances. I. Pediatr Nephrol 1991;5:743–50
    CrossRefPubMedWeb of Science
  75. 75.↵
    1. Lien YH
    . Role of organic osmolytes in myelinolysis: a topographic study in rats after rapid correction of hyponatremia. J Clin Invest 1995;95:1579–86
    CrossRefPubMedWeb of Science
  76. 76.↵
    1. Chu K,
    2. Kang DW,
    3. Ko SB,
    4. et al
    . Diffusion-weighted MR findings of central pontine and extrapontine myelinolysis. Acta Neurol Scand 2001;104:385–88
    CrossRefPubMedWeb of Science
  77. 77.↵
    1. Hurley RA,
    2. Filley CM,
    3. Taber KH
    . Central pontine myelinolysis: a metabolic disorder of myelin. J Neuropsychiatry Clin Neurosci 2011;23:369–74
    PubMed
  78. 78.↵
    1. Louis G,
    2. Megarbane B,
    3. Lavoué S,
    4. et al
    . Long-term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis. Crit Care Med 2012;40:970–72
    CrossRefPubMedWeb of Science
  79. 79.↵
    1. Menger H,
    2. Mackowski J,
    3. Jörg J,
    4. et al
    . Pontine and extra-pontine myelinolysis: early diagnostic and prognostic value of cerebral CT and MRI [in German]. Nervenarzt 1998;69:1083–90
    CrossRefPubMed
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American Journal of Neuroradiology: 34 (12)
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Vol. 34, Issue 12
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F.Y. Ismail, A. Szóllics, M. Szólics, N. Nagelkerke, M. Ljubisavljevic
Clinical Semiology and Neuroradiologic Correlates of Acute Hypernatremic Osmotic Challenge in Adults: A Literature Review
American Journal of Neuroradiology Dec 2013, 34 (12) 2225-2232; DOI: 10.3174/ajnr.A3392

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Clinical Semiology and Neuroradiologic Correlates of Acute Hypernatremic Osmotic Challenge in Adults: A Literature Review
F.Y. Ismail, A. Szóllics, M. Szólics, N. Nagelkerke, M. Ljubisavljevic
American Journal of Neuroradiology Dec 2013, 34 (12) 2225-2232; DOI: 10.3174/ajnr.A3392
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