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Research ArticleBrain

Early Basal Ganglia Hyperperfusion on CT Perfusion in Acute Ischemic Stroke: A Marker of Irreversible Damage?

V. Shahi, J.E. Fugate, D.F. Kallmes and A.A. Rabinstein
American Journal of Neuroradiology September 2014, 35 (9) 1688-1692; DOI: https://doi.org/10.3174/ajnr.A3935
V. Shahi
aFrom the Mayo Medical School (V.S.)
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J.E. Fugate
bDepartments of Neurology (J.E.F., A.A.R.)
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D.F. Kallmes
cRadiology (D.F.K.), Mayo Clinic, Rochester, Minnesota.
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A.A. Rabinstein
bDepartments of Neurology (J.E.F., A.A.R.)
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    Fig 1.

    Hyperperfusion in the right basal ganglia is demonstrated by increased cerebral blood flow (arrows, A) and increased cerebral blood volume (arrows, B). Also seen is a large region of right middle cerebral artery territory ischemia as evidenced by reduced CBF (A) with relative preservation of CBV (B). Lateral digital subtraction angiogram from a right carotid artery injection demonstrates early opacification of the basal vein of Rosenthal (solid arrow, C) and the internal cerebral vein (dashed arrow, C). Follow-up MR imaging 12 hours later shows restricted diffusion indicating infarction of the right basal ganglia, along with patchy cortical infarctions in the right MCA territory (D).

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    Fig 2.

    Hyperperfusion of the left basal ganglia is shown by increased cerebral blood flow (arrow, A) and increased cerebral blood volume (arrow, B) on CT perfusion. Follow-up FLAIR MR imaging 3.5 days later shows regions of T2 hyperintensity indicating infarction of this same region (C and D).

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    Fig 3.

    Increased cerebral blood flow in the right basal ganglia (arrow, A) in addition to a large region of reduced CBF in the right middle cerebral artery territory is shown on the CT perfusion scan at presentation. Noncontrast head CT 1 day later demonstrates right MCA infarction but apparent sparing of the right basal ganglia (B). Follow-up CT at day 6 shows hypoattenuation involving right basal ganglia (arrow, C) in addition to evolution of a large right MCA infarction with mass effect.

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  • Baseline patient characteristics

    Age/SexHTNCADDMA. fibInitial BP, (mm Hg)NIHSSMCA TerritoryTime to CTP (mins)aTICI GradeICH
    179/FYNNN125/6316R3432aY
    261/MNYNY116/7021L1872bY
    361/MNNNN114/7217R1252bN
    466/MYNNY155/9921L1902bN
    561/FYNNN140/8020R2300N
    665/FYNNN146/9216L210NAbN
    • Note:—HTN indicates hypertension; CAD, coronary artery disease; DM, diabetes mellitus; A. fib, atrial fibrillation; BP, blood pressure; ICH, intracranial hemorrhage; R, right; L, left; Y, yes; N, no; NA, not applicable.

    • ↵a TICI 0 indicates no perfusion; 2a, perfusion of ≤50% of MCA distribution; 2b, perfusion of >50% of MCA distribution; 3, full perfusion.

    • ↵b Endovascular therapy was not attempted because of large core on CTP.

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American Journal of Neuroradiology: 35 (9)
American Journal of Neuroradiology
Vol. 35, Issue 9
1 Sep 2014
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Cite this article
V. Shahi, J.E. Fugate, D.F. Kallmes, A.A. Rabinstein
Early Basal Ganglia Hyperperfusion on CT Perfusion in Acute Ischemic Stroke: A Marker of Irreversible Damage?
American Journal of Neuroradiology Sep 2014, 35 (9) 1688-1692; DOI: 10.3174/ajnr.A3935

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Early Basal Ganglia Hyperperfusion on CT Perfusion in Acute Ischemic Stroke: A Marker of Irreversible Damage?
V. Shahi, J.E. Fugate, D.F. Kallmes, A.A. Rabinstein
American Journal of Neuroradiology Sep 2014, 35 (9) 1688-1692; DOI: 10.3174/ajnr.A3935
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