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Research ArticleInterventional

Thromboembolic Complications in Patients with Clopidogrel Resistance after Coil Embolization for Unruptured Intracranial Aneurysms

B. Kim, K. Kim, P. Jeon, S. Kim, H. Kim, H. Byun, J. Cha, S. Hong and K. Jo
American Journal of Neuroradiology September 2014, 35 (9) 1786-1792; DOI: https://doi.org/10.3174/ajnr.A3955
B. Kim
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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K. Kim
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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P. Jeon
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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S. Kim
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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H. Kim
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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H. Byun
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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J. Cha
aFrom the Departments of Radiology (B.K., K.K., P.J., S.K., H.K., H.B., J.C.)
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S. Hong
bNeurosurgery (S.H., K.J.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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K. Jo
bNeurosurgery (S.H., K.J.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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REFERENCES

  1. 1.↵
    1. Gurbel PA,
    2. Bliden KP,
    3. Hiatt BL,
    4. et al
    . Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003;107:2908–13
    Abstract/FREE Full Text
  2. 2.↵
    1. Fifi JT,
    2. Brockington C,
    3. Narang J,
    4. et al
    . Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting. AJNR Am J Neuroradiol 2013;34:716–20
    Abstract/FREE Full Text
  3. 3.↵
    1. Kang HS,
    2. Kwon BJ,
    3. Kim JE,
    4. et al
    . Preinterventional clopidogrel response variability for coil embolization of intracranial aneurysms: clinical implications. AJNR Am J Neuroradiol 2010;31:1206–10
    Abstract/FREE Full Text
  4. 4.↵
    1. Delgado Almandoz JE,
    2. Kadkhodayan Y,
    3. Crandall BM,
    4. et al
    . Variability in initial response to standard clopidogrel therapy, delayed conversion to clopidogrel hyper-response, and associated thromboembolic and hemorrhagic complications in patients undergoing endovascular treatment of unruptured cerebral aneurysms. J Neurointerv Surg 2014 Jan 7. [Epub ahead of print]
  5. 5.↵
    1. Cronqvist M,
    2. Wirestam R,
    3. Ramgren B,
    4. et al
    . Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome. Neuroradiology 2005;47:855–73
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Altay T,
    2. Kang HI,
    3. Woo HH,
    4. et al
    . Thromboembolic events associated with endovascular treatment of cerebral aneurysms. J Neurointerv Surg 2011;3:147–50
    Abstract/FREE Full Text
  7. 7.↵
    1. Pierot L,
    2. Spelle L,
    3. Vitry F,
    4. et al
    . Immediate clinical outcome of patients harboring unruptured intracranial aneurysms treated by endovascular approach: results of the ATENA study. Stroke 2008;39:2497–504
    Abstract/FREE Full Text
  8. 8.↵
    1. Lee DH,
    2. Arat A,
    3. Morsi H,
    4. et al
    . Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience. AJNR Am J Neuroradiol 2008;29:1389–94
    Abstract/FREE Full Text
  9. 9.↵
    1. Gurbel PA,
    2. Tantry US
    . Clopidogrel resistance? Thromb Res 2007;120:311–21
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Delgado Almandoz JE,
    2. Crandall BM,
    3. Scholz JM,
    4. et al
    . Pre-procedure P2Y12 reaction units value predicts perioperative thromboembolic and hemorrhagic complications in patients with cerebral aneurysms treated with the Pipeline embolization device. J Neurointerv Surg 2013;5(suppl 3):iii3–10
    Abstract/FREE Full Text
  11. 11.↵
    1. Maruyama H,
    2. Takeda H,
    3. Dembo T,
    4. et al
    . Clopidogrel resistance and the effect of combination cilostazol in patients with ischemic stroke or carotid artery stenting using the VerifyNow P2Y12 assay. Intern Med 2011;50:695–98
    CrossRefPubMed
  12. 12.↵
    1. Jo KI,
    2. Yeon JY,
    3. Kim KH,
    4. et al
    . Predictors of thromboembolism during coil embolization in patients with unruptured intracranial aneurysm. Acta Neurochir (Wien) 2013;155:1101–06
    PubMed
  13. 13.↵
    1. Brooks NP,
    2. Turk AS,
    3. Niemann DB,
    4. et al
    . Frequency of thromboembolic events associated with endovascular aneurysm treatment: retrospective case series. J Neurosurg 2008;108:1095–100
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Adams HP Jr.,
    2. Bendixen BH,
    3. Kappelle LJ,
    4. et al
    . Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST–Trial of Org 10172 in acute stroke treatment. Stroke 1993;24:35–41
    Abstract/FREE Full Text
  15. 15.↵
    1. Workman MJ,
    2. Cloft HJ,
    3. Tong FC,
    4. et al
    . Thrombus formation at the neck of cerebral aneurysms during treatment with Guglielmi detachable coils. AJNR Am J Neuroradiol 2002;23:1568–76
    Abstract/FREE Full Text
  16. 16.↵
    1. Delgado Almandoz JE,
    2. Crandall BM,
    3. Scholz JM,
    4. et al
    . Last-recorded P2Y12 reaction units value is strongly associated with thromboembolic and hemorrhagic complications occurring up to 6 months after treatment in patients with cerebral aneurysms treated with the Pipeline embolization device. AJNR Am J Neuroradiol 2014;35:128–35
    Abstract/FREE Full Text
  17. 17.↵
    1. Bendszus M,
    2. Stoll G
    . Silent cerebral ischaemia: hidden fingerprints of invasive medical procedures. Lancet Neurol 2006;5:364–72
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Knipp SC,
    2. Matatko N,
    3. Wilhelm H,
    4. et al
    . Evaluation of brain injury after coronary artery bypass grafting. A prospective study using neuropsychological assessment and diffusion-weighted magnetic resonance imaging. Eur J Cardiothorac Surg 2004;25:791–800
    Abstract/FREE Full Text
  19. 19.↵
    1. Restrepo L,
    2. Wityk RJ,
    3. Grega MA,
    4. et al
    . Diffusion- and perfusion-weighted magnetic resonance imaging of the brain before and after coronary artery bypass grafting surgery. Stroke 2002;33:2909–15
    Abstract/FREE Full Text
  20. 20.↵
    1. Rordorf G,
    2. Bellon RJ,
    3. Budzik RE Jr..,
    4. et al
    . Silent thromboembolic events associated with the treatment of unruptured cerebral aneurysms by use of Guglielmi detachable coils: prospective study applying diffusion-weighted imaging. AJNR Am J Neuroradiol 2001;22:5–10
    Abstract/FREE Full Text
  21. 21.↵
    1. van Rooij WJ,
    2. Sluzewski M,
    3. Beute GN,
    4. et al
    . Procedural complications of coiling of ruptured intracranial aneurysms: incidence and risk factors in a consecutive series of 681 patients. AJNR Am J Neuroradiol 2006;27:1498–501
    Abstract/FREE Full Text
  22. 22.↵
    1. Kang DH,
    2. Kim BM,
    3. Kim DJ,
    4. et al
    . MR-DWI-positive lesions and symptomatic ischemic complications after coiling of unruptured intracranial aneurysms. Stroke 2013;44:789–91
    Abstract/FREE Full Text
  23. 23.↵
    1. Hu YC,
    2. Deshmukh VR,
    3. Albuquerque FC,
    4. et al
    . Histopathological assessment of fatal ipsilateral intraparenchymal hemorrhages after the treatment of supraclinoid aneurysms with the Pipeline embolization device. J Neurosurg 2014;120:365–74
    PubMedWeb of Science
  24. 24.↵
    1. Kim BJ,
    2. Lee SW,
    3. Park SW,
    4. et al
    . Insufficient platelet inhibition is related to silent embolic cerebral infarctions after coronary angiography. Stroke 2012;43:727–32
    Abstract/FREE Full Text
  25. 25.↵
    1. Busing KA,
    2. Schulte-Sasse C,
    3. Fluchter S,
    4. et al
    . Cerebral infarction: incidence and risk factors after diagnostic and interventional cardiac catheterization–prospective evaluation at diffusion-weighted MR imaging. Radiology 2005;235:177–83
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Brockmann C,
    2. Hoefer T,
    3. Diepers M,
    4. et al
    . Abciximab does not prevent ischemic lesions related to cerebral angiography: a randomized placebo-controlled trial. Cerebrovasc Dis 2011;31:353–57
    CrossRefPubMed
  27. 27.↵
    1. Albayram S,
    2. Selcuk H,
    3. Kara B,
    4. et al
    . Thromboembolic events associated with balloon-assisted coil embolization: evaluation with diffusion-weighted MR imaging. AJNR Am J Neuroradiol 2004;25:1768–77
    Abstract/FREE Full Text
  28. 28.↵
    1. Qureshi AI,
    2. Mohammad Y,
    3. Yahia AM,
    4. et al
    . Ischemic events associated with unruptured intracranial aneurysms: multicenter clinical study and review of the literature. Neurosurgery 2000;46:282–89; discussion 89–90
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 35 (9)
American Journal of Neuroradiology
Vol. 35, Issue 9
1 Sep 2014
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Cite this article
B. Kim, K. Kim, P. Jeon, S. Kim, H. Kim, H. Byun, J. Cha, S. Hong, K. Jo
Thromboembolic Complications in Patients with Clopidogrel Resistance after Coil Embolization for Unruptured Intracranial Aneurysms
American Journal of Neuroradiology Sep 2014, 35 (9) 1786-1792; DOI: 10.3174/ajnr.A3955

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Thromboembolic Complications in Patients with Clopidogrel Resistance after Coil Embolization for Unruptured Intracranial Aneurysms
B. Kim, K. Kim, P. Jeon, S. Kim, H. Kim, H. Byun, J. Cha, S. Hong, K. Jo
American Journal of Neuroradiology Sep 2014, 35 (9) 1786-1792; DOI: 10.3174/ajnr.A3955
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