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Research ArticleBrain

Effects of Agmatine on Blood-Brain Barrier Stabilization Assessed by Permeability MRI in a Rat Model of Transient Cerebral Ischemia

S.S. Ahn, S.H. Kim, J.E. Lee, K.J. Ahn, D.J. Kim, H.S. Choi, J. Kim, N.-Y. Shin and S.-K. Lee
American Journal of Neuroradiology February 2015, 36 (2) 283-288; DOI: https://doi.org/10.3174/ajnr.A4113
S.S. Ahn
aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
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S.H. Kim
bDepartment of Pathology (S.H.K.), Brain Research Institute
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J.E. Lee
cDepartment of Anatomy (J.E.L.), Yonsei University College of Medicine, Seoul, Republic of Korea
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K.J. Ahn
dDepartment of Radiology (K.J.A., H.S.C.), The Catholic University College of Medicine, Seoul, Seoul, Republic of Korea.
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D.J. Kim
aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
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H.S. Choi
dDepartment of Radiology (K.J.A., H.S.C.), The Catholic University College of Medicine, Seoul, Seoul, Republic of Korea.
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J. Kim
aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
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N.-Y. Shin
aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
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S.-K. Lee
aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
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Article Information

vol. 36 no. 2 283-288
DOI 
https://doi.org/10.3174/ajnr.A4113
PubMed 
25273536

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received April 28, 2014
  • Accepted after revision July 31, 2014
  • Published online February 11, 2015.

Copyright & Usage 
© 2015 by American Journal of Neuroradiology

Author Information

  1. S.S. Ahna,
  2. S.H. Kimb,
  3. J.E. Leec,
  4. K.J. Ahnd,
  5. D.J. Kima,
  6. H.S. Choid,
  7. J. Kima,
  8. N.-Y. Shina and
  9. S.-K. Leea
  1. aFrom the Department of Radiology and the Research Institute of Radiological Science (S.S.A., D.J.K., J.K., N.-Y.S., S.-K.L.)
  2. bDepartment of Pathology (S.H.K.), Brain Research Institute
  3. cDepartment of Anatomy (J.E.L.), Yonsei University College of Medicine, Seoul, Republic of Korea
  4. dDepartment of Radiology (K.J.A., H.S.C.), The Catholic University College of Medicine, Seoul, Seoul, Republic of Korea.
  1. Please address correspondence to Seung-Koo Lee, MD, PhD, Department of Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea; e-mail: slee{at}yuhs.ac, lee.seungkoo{at}gmail.com
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  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
    Somang Kang, Chul-Hoon Kim, Hosung Jung, Eosu Kim, Ho-Taek Song, Jong Eun Lee
    Neuropharmacology 2017 113
  • Neuroprotective offerings by agmatine
    Nandkishor Ramdas Kotagale, Brijesh Gulabrao Taksande, Nazma Najirahmad Inamdar
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  • Agmatine, a potential novel therapeutic strategy for depression
    Andiara E. Freitas, Vivian B. Neis, Ana Lúcia S. Rodrigues
    European Neuropsychopharmacology 2016 26 12
  • Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death
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    Cells 2020 9 6
  • Neuroprotection by agmatine: Possible involvement of the gut microbiome?
    Priyanka Saha, Subhrajita Panda, Aayusha Holkar, Rahul Vashishth, Sandeep Singh Rana, Mohanapriya Arumugam, Ghulam Md Ashraf, Shafiul Haque, Faraz Ahmad
    Ageing Research Reviews 2023 91
  • Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape
    Devon Watts, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Luiza Paul Géa, Taiane De Azevedo Cardoso, Flavio Kapczinski
    Expert Opinion on Therapeutic Targets 2019 23 4
  • Aspalathus linearis (Rooibos) and Agmatine May Act Synergistically to Beneficially Modulate Intestinal Tight Junction Integrity and Inflammatory Profile
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  • How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke
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    International Journal of Molecular Sciences 2020 21 17
  • Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models
    V. Selakovic, Lj Arsenijevic, M. Jovanovic, S. Sivcev, N. Jovanovic, M. Leontijevic, M. Stojanovic, M. Radenkovic, P. Andjus, L. Radenovic
    Brain Research Bulletin 2019 146
  • Different Contacted Cell Types Contribute to Acquiring Different Properties in Brain Microglial Cells upon Intercellular Interaction
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    International Journal of Molecular Sciences 2023 24 2
  • Role of Agmatine on Neuroglia in Central Nervous System Injury
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  • Agmatine: An Emerging Approach for Neuroprotection in Recurrent Ischemic Stroke Events in a Murine Model
    M. L. Miranda‐Mosqueda, S. Y. Ruiz‐Oropeza, J. A. González‐Barrios, R. Jaimez, Fernando Peña‐Ortega, C. Gómez‐Acevedo
    Drug Development Research 2024 85 7
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Cite this article
S.S. Ahn, S.H. Kim, J.E. Lee, K.J. Ahn, D.J. Kim, H.S. Choi, J. Kim, N.-Y. Shin, S.-K. Lee
Effects of Agmatine on Blood-Brain Barrier Stabilization Assessed by Permeability MRI in a Rat Model of Transient Cerebral Ischemia
American Journal of Neuroradiology Feb 2015, 36 (2) 283-288; DOI: 10.3174/ajnr.A4113

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Effects of Agmatine on Blood-Brain Barrier Stabilization Assessed by Permeability MRI in a Rat Model of Transient Cerebral Ischemia
S.S. Ahn, S.H. Kim, J.E. Lee, K.J. Ahn, D.J. Kim, H.S. Choi, J. Kim, N.-Y. Shin, S.-K. Lee
American Journal of Neuroradiology Feb 2015, 36 (2) 283-288; DOI: 10.3174/ajnr.A4113
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Cited By...

  • Agmatine: multifunctional arginine metabolite and magic bullet in clinical neuroscience?
  • Crossref (14)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Agmatine: multifunctional arginine metabolite and magic bullet in clinical neuroscience?
    Gregor Laube, Hans-Gert Bernstein
    Biochemical Journal 2017 474 15
  • Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
    Somang Kang, Chul-Hoon Kim, Hosung Jung, Eosu Kim, Ho-Taek Song, Jong Eun Lee
    Neuropharmacology 2017 113
  • Neuroprotective offerings by agmatine
    Nandkishor Ramdas Kotagale, Brijesh Gulabrao Taksande, Nazma Najirahmad Inamdar
    NeuroToxicology 2019 73
  • Agmatine, a potential novel therapeutic strategy for depression
    Andiara E. Freitas, Vivian B. Neis, Ana Lúcia S. Rodrigues
    European Neuropsychopharmacology 2016 26 12
  • Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death
    Yasue Tanaka, Nami Nakagomi, Nobutaka Doe, Akiko Nakano-Doi, Toshinori Sawano, Toshinori Takagi, Tomohiro Matsuyama, Shinichi Yoshimura, Takayuki Nakagomi
    Cells 2020 9 6
  • Neuroprotection by agmatine: Possible involvement of the gut microbiome?
    Priyanka Saha, Subhrajita Panda, Aayusha Holkar, Rahul Vashishth, Sandeep Singh Rana, Mohanapriya Arumugam, Ghulam Md Ashraf, Shafiul Haque, Faraz Ahmad
    Ageing Research Reviews 2023 91
  • Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape
    Devon Watts, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Luiza Paul Géa, Taiane De Azevedo Cardoso, Flavio Kapczinski
    Expert Opinion on Therapeutic Targets 2019 23 4
  • Aspalathus linearis (Rooibos) and Agmatine May Act Synergistically to Beneficially Modulate Intestinal Tight Junction Integrity and Inflammatory Profile
    L. Pretorius, C. Smith
    Pharmaceuticals 2022 15 9
  • Tyramine-induced gastrointestinal dysregulation is attenuated via estradiol associated mechanisms in a zebrafish larval model
    L. Pretorius, C. Smith
    Toxicology and Applied Pharmacology 2023 461
  • How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke
    Takayuki Nakagomi, Yasue Tanaka, Nami Nakagomi, Tomohiro Matsuyama, Shinichi Yoshimura
    International Journal of Molecular Sciences 2020 21 17

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