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Research ArticleAdult Brain
Open Access

Manganese-Enhanced MRI of the Brain in Healthy Volunteers

D.M. Sudarshana, G. Nair, J.T. Dwyer, B. Dewey, S.U. Steele, D.J. Suto, T. Wu, B.A. Berkowitz, A.P. Koretsky, I.C.M. Cortese and D.S. Reich
American Journal of Neuroradiology August 2019, 40 (8) 1309-1316; DOI: https://doi.org/10.3174/ajnr.A6152
D.M. Sudarshana
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
bCleveland Clinic Lerner College of Medicine of Case Western Reserve University (D.M.S.), Cleveland, Ohio
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G. Nair
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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J.T. Dwyer
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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B. Dewey
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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S.U. Steele
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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D.J. Suto
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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T. Wu
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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B.A. Berkowitz
cDepartment of Ophthalmology (B.A.B.), Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan.
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A.P. Koretsky
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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I.C.M. Cortese
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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D.S. Reich
aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
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Article Information

vol. 40 no. 8 1309-1316
DOI 
https://doi.org/10.3174/ajnr.A6152
PubMed 
31371354

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received January 18, 2019
  • Accepted after revision June 13, 2019
  • Published online August 14, 2019.

Copyright & Usage 
© 2019 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. D.M. Sudarshanaa,b,
  2. G. Naira,
  3. J.T. Dwyera,
  4. B. Deweya,
  5. S.U. Steelea,
  6. D.J. Sutoa,
  7. T. Wua,
  8. B.A. Berkowitzc,
  9. A.P. Koretskya,
  10. I.C.M. Cortesea and
  11. D.S. Reicha
  1. aFrom the National Institute of Neurological Disorders and Stroke (D.M.S., G.N., J.T.D., B.D., S.U.S., D.J.S., T.W., A.P.K., I.C.M.C., D.S.R.), National Institutes of Health, Bethesda, Maryland
  2. bCleveland Clinic Lerner College of Medicine of Case Western Reserve University (D.M.S.), Cleveland, Ohio
  3. cDepartment of Ophthalmology (B.A.B.), Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, Michigan.
  1. Please address correspondence to Daniel S. Reich, MD, PhD, Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke/National Institutes of Health, 10 Center Dr MSC 1400, Building 10 Room 5C103, Bethesda, MD 20892; E-mail: daniel.reich{at}nih.gov
View Full Text

Funding

  • National Eye Institute

    EY026584
  • Intramural Research Program of National Institute of Neurological Disorders and Stroke

    Z01NS003119
  • National Institute of Aging

    AG058171
  • NIH Medical Research Scholars Program

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D.M. Sudarshana, G. Nair, J.T. Dwyer, B. Dewey, S.U. Steele, D.J. Suto, T. Wu, B.A. Berkowitz, A.P. Koretsky, I.C.M. Cortese, D.S. Reich
Manganese-Enhanced MRI of the Brain in Healthy Volunteers
American Journal of Neuroradiology Aug 2019, 40 (8) 1309-1316; DOI: 10.3174/ajnr.A6152

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Manganese-Enhanced MRI of the Brain in Healthy Volunteers
D.M. Sudarshana, G. Nair, J.T. Dwyer, B. Dewey, S.U. Steele, D.J. Suto, T. Wu, B.A. Berkowitz, A.P. Koretsky, I.C.M. Cortese, D.S. Reich
American Journal of Neuroradiology Aug 2019, 40 (8) 1309-1316; DOI: 10.3174/ajnr.A6152
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  • Crossref (25)
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

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    Pharmaceutics 2021 13 7
  • Longitudinal manganese‐enhanced magnetic resonance imaging of neural projections and activity
    Taylor W. Uselman, Christopher S. Medina, Harry B. Gray, Russell E. Jacobs, Elaine L. Bearer
    NMR in Biomedicine 2022 35 6
  • In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
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