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Research ArticleBrain Tumor Imaging

Identification of a Single-Dose, Low-Flip-Angle–Based CBV Threshold for Fractional Tumor Burden Mapping in Recurrent Glioblastoma

Aliya Anil, Ashley M. Stokes, John P. Karis, Laura C. Bell, Jennifer Eschbacher, Kristofer Jennings, Melissa A. Prah, Leland S. Hu, Jerrold L. Boxerman, Kathleen M. Schmainda and C. Chad Quarles
American Journal of Neuroradiology October 2024, 45 (10) 1545-1551; DOI: https://doi.org/10.3174/ajnr.A8357
Aliya Anil
aFrom the Cancer System Imaging (A.A., C.C.Q.), The University of Texas MD Anderson Cancer Center, Houston, Texas
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  • ORCID record for Aliya Anil
Ashley M. Stokes
bDivision of Neuroimaging Research and Barrow Neuroimaging Innovation Center (A.M.S.), Barrow Neurological Institute, Phoenix, Arizona
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  • ORCID record for Ashley M. Stokes
John P. Karis
cDepartment of Neuroradiology (J.P.K.), Barrow Neurological Institute, Phoenix, Arizona
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Laura C. Bell
dClinical Imaging Group (L.C.B.), Genentech Inc., San Francisco, California
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Jennifer Eschbacher
eDepartment of Neuropathology (J.E.), Barrow Neurological Institute, Phoenix, Arizona
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Kristofer Jennings
fDepartment of Biostatistics (K.J.), The University of Texas MD Anderson Cancer Center, Houston, Texas
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Melissa A. Prah
gDepartment of Biophysics (M.A.P., K.M.S.), Medical College of Wisconsin, Milwaukee, Wisconsin
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Leland S. Hu
hDepartment of Radiology (L.S.H.), Division of Neuroradiology, Mayo Clinic Arizona, Phoenix, Arizona
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Jerrold L. Boxerman
iDepartment of Diagnostic Imaging (J.L.B.), Rhode Island Hospital, Providence, Rhode Island
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Kathleen M. Schmainda
gDepartment of Biophysics (M.A.P., K.M.S.), Medical College of Wisconsin, Milwaukee, Wisconsin
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C. Chad Quarles
aFrom the Cancer System Imaging (A.A., C.C.Q.), The University of Texas MD Anderson Cancer Center, Houston, Texas
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Article Information

vol. 45 no. 10 1545-1551
DOI 
https://doi.org/10.3174/ajnr.A8357
PubMed 
38782593

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 1, 2024
  • Accepted after revision May 21, 2024
  • Published online October 3, 2024.

Copyright & Usage 
© 2024 by American Journal of Neuroradiology

Author Information

  1. Aliya Anila,
  2. Ashley M. Stokesb,
  3. John P. Karisc,
  4. Laura C. Belld,
  5. Jennifer Eschbachere,
  6. Kristofer Jenningsf,
  7. Melissa A. Prahg,
  8. Leland S. Huh,
  9. Jerrold L. Boxermani,
  10. Kathleen M. Schmaindag and
  11. C. Chad Quarlesa
  1. aFrom the Cancer System Imaging (A.A., C.C.Q.), The University of Texas MD Anderson Cancer Center, Houston, Texas
  2. bDivision of Neuroimaging Research and Barrow Neuroimaging Innovation Center (A.M.S.), Barrow Neurological Institute, Phoenix, Arizona
  3. cDepartment of Neuroradiology (J.P.K.), Barrow Neurological Institute, Phoenix, Arizona
  4. dClinical Imaging Group (L.C.B.), Genentech Inc., San Francisco, California
  5. eDepartment of Neuropathology (J.E.), Barrow Neurological Institute, Phoenix, Arizona
  6. fDepartment of Biostatistics (K.J.), The University of Texas MD Anderson Cancer Center, Houston, Texas
  7. gDepartment of Biophysics (M.A.P., K.M.S.), Medical College of Wisconsin, Milwaukee, Wisconsin
  8. hDepartment of Radiology (L.S.H.), Division of Neuroradiology, Mayo Clinic Arizona, Phoenix, Arizona
  9. iDepartment of Diagnostic Imaging (J.L.B.), Rhode Island Hospital, Providence, Rhode Island
  1. Please address correspondence to C. Chad Quarles, Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1881 East Rd, Unit 1907, Houston, TX 77054; e-mail: ccquarles{at}mdanderson.org
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Funding

  • National Institutes of Health

    R01 CA213158; R01 CA264992; U01 CA176110
  • Cancer Prevention and Research Institute of Texas

    RR220038

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    Neuroradiologie Scan 2025 15 02
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Cite this article
Aliya Anil, Ashley M. Stokes, John P. Karis, Laura C. Bell, Jennifer Eschbacher, Kristofer Jennings, Melissa A. Prah, Leland S. Hu, Jerrold L. Boxerman, Kathleen M. Schmainda, C. Chad Quarles
Identification of a Single-Dose, Low-Flip-Angle–Based CBV Threshold for Fractional Tumor Burden Mapping in Recurrent Glioblastoma
American Journal of Neuroradiology Oct 2024, 45 (10) 1545-1551; DOI: 10.3174/ajnr.A8357

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Low-Flip-Angle CBV Threshold in Glioblastoma
Aliya Anil, Ashley M. Stokes, John P. Karis, Laura C. Bell, Jennifer Eschbacher, Kristofer Jennings, Melissa A. Prah, Leland S. Hu, Jerrold L. Boxerman, Kathleen M. Schmainda, C. Chad Quarles
American Journal of Neuroradiology Oct 2024, 45 (10) 1545-1551; DOI: 10.3174/ajnr.A8357
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    Neuroradiologie Scan 2025 15 02

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