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Research ArticleNeurovascular/Stroke Imaging

Hemorrhage Volume Drives Early Brain Injury and Outcome in Poor-Grade Aneurysmal SAH

Pietro Panni, Franco Simionato, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Andrea Alexandre, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Raffaele Aspide, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Maria Luisa Azzolini, Maria Rosa Calvi, Andrea Falini and on behalf of the POGASH Investigators
American Journal of Neuroradiology April 2024, 45 (4) 393-399; DOI: https://doi.org/10.3174/ajnr.A8135
Pietro Panni
aFrom the Department of Neuroradiology (P.P., F.S., R.C., A. Falini), Division of Interventional Neuroradiology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
bDepartment of Neurosurgery (P.P., P.M.), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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Franco Simionato
aFrom the Department of Neuroradiology (P.P., F.S., R.C., A. Falini), Division of Interventional Neuroradiology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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Roberta Cao
aFrom the Department of Neuroradiology (P.P., F.S., R.C., A. Falini), Division of Interventional Neuroradiology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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Alessandro Pedicelli
cInstitute of Radiological Sciences (A.P., A. Alexandre). Policlinico Universitario A.Gemelli IRCCS Catholic University of Rome, Rome, Italy
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Enrico Marchese
dDepartment of Neurosurgery (E.M.), Policlinico Universitario A.Gemelli IRCCS Catholic University of Rome, Rome, Italy
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Anselmo Caricato
eDepartment of Anesthesia and Critical Care Medicine (A.C.), Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of Rome, Rome, Italy
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Andrea Alexandre
cInstitute of Radiological Sciences (A.P., A. Alexandre). Policlinico Universitario A.Gemelli IRCCS Catholic University of Rome, Rome, Italy
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Alberto Feletti
fInstitute of Neurosurgery (A. Feletti, M.T), Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
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Mattia Testa
fInstitute of Neurosurgery (A. Feletti, M.T), Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
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Paolo Zanatta
gAnesthesia and Intensive Care A (P.Z.), Integrated University Hospital, Verona, Italy
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Nicola Gitti
hDepartment of Anesthesia, Critical Care and Emergency (N.G., S.P.), Spedali Civili University Hospital, Brescia, Italy
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Simone Piva
hDepartment of Anesthesia, Critical Care and Emergency (N.G., S.P.), Spedali Civili University Hospital, Brescia, Italy
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Dikran Mardighian
iDepartment of Neuroradiology (D.M.), Spedali Civili University Hospital, Brescia, Italy
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Vittorio Semeraro
jDepartment of Radiology (V.S.), SS Annunziata Hospital, Taranto, Italy
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  • ORCID record for Vittorio Semeraro
Giordano Nardin
kDepartment of Critical Care (G.N.), SS Annunziata Hospital, Taranto, Italy
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Emilio Lozupone
lDepartment of Neuroradiology (E.L.), Vito-Fazzi Hospital, Lecce, Italy
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  • ORCID record for Emilio Lozupone
Giafranco Paiano
mDepartment of Anaesthesia and Critical Care (G.P.), Vito-Fazzi Hospital, Lecce, Italy
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Edoardo Picetti
nDepartment of Anesthesia and Intensive Care (E.P., V.M., M.P), Parma University Hospital, Parma, Italy
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Vito Montanaro
nDepartment of Anesthesia and Intensive Care (E.P., V.M., M.P), Parma University Hospital, Parma, Italy
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Massimo Petranca
nDepartment of Anesthesia and Intensive Care (E.P., V.M., M.P), Parma University Hospital, Parma, Italy
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Carlo Bortolotti
oDepartment of Neurosurgery (C.B., A.S.), IRCCS Institute of Neurological Sciences “Bellaria,” Bologna, Italy
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Antonino Scibilia
oDepartment of Neurosurgery (C.B., A.S.), IRCCS Institute of Neurological Sciences “Bellaria,” Bologna, Italy
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Luigi Cirillo
pDepartment of Neuroradiology (L.C.), IRCCS Institute of Neurological Sciences “Bellaria,” Bologna, Italy
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  • ORCID record for Luigi Cirillo
Raffaele Aspide
qDepartment of Neurointensive Care (R.A.), IRCCS Institute of Neurological Sciences “Bellaria,” Bologna, Italy
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Andrea Luigi Lanterna
rDepartment of Neurosurgery (A.L.L.), Papa Giovanni XXIII Hospital, Bergamo, Italy
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Alessandro Ambrosi
sBiostatistics, School of Medicine (A. Ambrosi), Vita-Salute San Raffaele University, Milan, Italy.
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Pietro Mortini
bDepartment of Neurosurgery (P.P., P.M.), IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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Maria Luisa Azzolini
tDeparment of Neurocritical Care (M.L.A., M.R.C.), San Raffaele University Hospital, Milan, Italy
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Maria Rosa Calvi
tDeparment of Neurocritical Care (M.L.A., M.R.C.), San Raffaele University Hospital, Milan, Italy
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Andrea Falini
aFrom the Department of Neuroradiology (P.P., F.S., R.C., A. Falini), Division of Interventional Neuroradiology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
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    FIG 1.

    Example of GHV semiautomatic segmentation with the neighboring method. The threshold was set between 45 and 90 HU. A and C, Basal hyperdensitites. B and D, The results of the semiautomatic segmentation of hemorrhage with a threshold set between 45 and 90 HU.

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    FIG 2.

    Scatterplot showing multivariable analysis–derived predicted probabilities of severe SEBES (SEBES grades 3–4) on the admission CT scan according to age (3 groups: younger than 50, 50–70, older than 70 years of age) and baseline GHV.

  • FIG 3.
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    FIG 3.

    Scatterplot showing multivariable analysis–derived predicted probabilities of severe SEBES (SEBES grades 3–4) on the admission CT scan according to age (3 groups: younger than 50, 50–70, older than 70 years of age and baseline ICH-V (A), IVH-V (B), and SAH-V (C).

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American Journal of Neuroradiology: 45 (4)
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Pietro Panni, Franco Simionato, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Andrea Alexandre, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Raffaele Aspide, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Maria Luisa Azzolini, Maria Rosa Calvi, Andrea Falini, on behalf of the POGASH Investigators
Hemorrhage Volume Drives Early Brain Injury and Outcome in Poor-Grade Aneurysmal SAH
American Journal of Neuroradiology Apr 2024, 45 (4) 393-399; DOI: 10.3174/ajnr.A8135

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Hemorrhage Volume in Aneurysmal SAH
Pietro Panni, Franco Simionato, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Andrea Alexandre, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Raffaele Aspide, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Maria Luisa Azzolini, Maria Rosa Calvi, Andrea Falini, on behalf of the POGASH Investigators
American Journal of Neuroradiology Apr 2024, 45 (4) 393-399; DOI: 10.3174/ajnr.A8135
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