Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study

Ludovica Pasca; Filippo Arrigoni; Romina Romaniello; Maria Savina Severino; Davide Politano; Fulvio D’Abrusco; Jessica Garau; Valentina De Giorgis; Adriana Carpani; Sabrina Signorini; Simona Orcesi; Felice D’Arco; Enrico Alfei; Elisa Cattaneo; Elisa Rognone; Sara Uccella; Maria Teresa Divizia; Paolo Infantino; Enza Maria Valente; Renato Borgatti; Anna Pichiecchio

doi:10.3174/ajnr.A8450

Research ArticlePediatric Neuroimaging

Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study

Ludovica Pasca, Filippo Arrigoni, Romina Romaniello, Maria Savina Severino, Davide Politano, Fulvio D’Abrusco, Jessica Garau, Valentina De Giorgis, Adriana Carpani, Sabrina Signorini, Simona Orcesi, Felice D’Arco, Enrico Alfei, Elisa Cattaneo, Elisa Rognone, Sara Uccella, Maria Teresa Divizia, Paolo Infantino, Enza Maria Valente, Renato Borgatti and Anna Pichiecchio

American Journal of Neuroradiology January 2025, 46 (1) 170-177; DOI: https://doi.org/10.3174/ajnr.A8450

Ludovica Pasca

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Filippo Arrigoni

cRadiology and Neuroradiology Department (F.A.), Vittore Buzzi Children’s Hospital, Milan, Italy

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Romina Romaniello

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Maria Savina Severino

dNeuroradiology Unit (M.S.S.), IRCCS Istituto Giannina Gaslini, Genova, Italy

lNeuroradiology Unit (M.S.S.), Child Neuropsychiatry Unit (S.U.), IRCCS Istituto Giannina Gaslini, Genoa, Italy

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Davide Politano

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Fulvio D’Abrusco

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

eDepartment of Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

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Jessica Garau

fNeurogenetics Research Center (J.G., E.M.V.), IRCCS Mondino Foundation, Pavia, Italy

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Valentina De Giorgis

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Adriana Carpani

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Sabrina Signorini

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Simona Orcesi

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Felice D’Arco

gDepartment of Radiology (F.D.), Neuroradiology Unit, Great Ormond Street Hospital for Children, London, United Kingdom

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Enrico Alfei

hPediatric Neurology Unit (E.A.), and Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy

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Elisa Cattaneo

iClinical Genetics Unit (E.C.), Department of Pediatrics, Vittore Buzzi Children’s Hospital, Milan, Italy

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Elisa Rognone

jDepartment of Neuroradiology (E.R., A.P.), Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy

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Sara Uccella

kDepartment of Neurosciences (S.U.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy

lNeuroradiology Unit (M.S.S.), Child Neuropsychiatry Unit (S.U.), IRCCS Istituto Giannina Gaslini, Genoa, Italy

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Maria Teresa Divizia

mGenomics and Clinical Genetics Unit (M.T.D., P.I.), IRCCS Istituto Giannina Gaslini, Genoa, Italy

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Paolo Infantino

mGenomics and Clinical Genetics Unit (M.T.D., P.I.), IRCCS Istituto Giannina Gaslini, Genoa, Italy

nUniversità degli Studi di Genova (P.I.), Genoa, Italy

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Enza Maria Valente

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

eDepartment of Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

fNeurogenetics Research Center (J.G., E.M.V.), IRCCS Mondino Foundation, Pavia, Italy

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Renato Borgatti

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

bChild Neurology and Psychiatry Unit (L.P., R.R., D.P., V.D.G., A.C., S.S., S.O., R.B.), IRCCS Mondino Foundation, Pavia, Italy

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Anna Pichiecchio

aFrom the Departments of Brain and Behavioral Sciences (L.P., D.P., V.D.G., S.O., R.B., A.P.), and Molecular Medicine (F.D., E.M.V.), University of Pavia, Pavia, Italy

jDepartment of Neuroradiology (E.R., A.P.), Advanced Imaging and Radiomics Center, IRCCS Mondino Foundation, Pavia, Italy

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Neuroradiologic, Clinical, and Genetic Characterization of Cerebellar Heterotopia: A Pediatric Multicentric Study

American Journal of Neuroradiology Jan 2025, 46 (1) 170-177; DOI: 10.3174/ajnr.A8450

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Pediatric Cerebellar Heterotopia

American Journal of Neuroradiology Jan 2025, 46 (1) 170-177; DOI: 10.3174/ajnr.A8450

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