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Research ArticleEmergency Neuroradiology

Black Hole Sign under Anticoagulant Therapy: A Retrospective Comparison of Warfarin and Direct Oral Anticoagulants

Hirotaka Sato, Manabu Kinoshita, Takuma Takano, Takahiro Sanada, Seiya Fujikawa, Masahiro Toda, Kiyoshi Choji and Teruo Kimura
American Journal of Neuroradiology March 2025, 46 (3) 489-494; DOI: https://doi.org/10.3174/ajnr.A8528
Hirotaka Sato
aFrom the Department of Neurosurgery (H.S., T.S., T.K.), Japanese Kitami Red Cross Hospital, Hokkaido, Japan
bDepartment of Neurosurgery (M.K.), Asahikawa Medical University, Hokkaido, Japan
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Manabu Kinoshita
bDepartment of Neurosurgery (M.K.), Asahikawa Medical University, Hokkaido, Japan
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Takuma Takano
cDepartment of Neurosurgery (T.T.) (T.T.), Sapporo Higashi Tokushukai Hospital, Hokkaido, Japan
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Takahiro Sanada
aFrom the Department of Neurosurgery (H.S., T.S., T.K.), Japanese Kitami Red Cross Hospital, Hokkaido, Japan
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Seiya Fujikawa
dDepartment of Neurosurgery and Stroke Center (S.F.), Sapporo Teishinkai Hospital, Hokkaido, Japan
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Masahiro Toda
eDepartment of Radiology (M.T.), Asahikawa Medical University, Hokkaido, Japan
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Kiyoshi Choji
fDepartment of Radiology (K.C.), Japanese Kitami Red Cross Hospital, Hokkaido, Japan
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Teruo Kimura
aFrom the Department of Neurosurgery (H.S., T.S., T.K.), Japanese Kitami Red Cross Hospital, Hokkaido, Japan
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References

  1. 1.↵
    1. Chan NC,
    2. Paikin JS,
    3. Hirsh J, et al
    . New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions. Thromb Haemost 2014;111:798–807 doi:10.1160/TH13-11-0918 pmid:24553904
    CrossRefPubMed
  2. 2.↵
    1. Dowlatshahi D,
    2. Butcher KS,
    3. Asdaghi N
    ; Canadian PCC Registry (CanPro) Investigators, et al. Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal. Stroke 2012;43:1812–17 doi:10.1161/STROKEAHA.112.652065 pmid:22556194
    Abstract/FREE Full Text
  3. 3.↵
    1. Kurogi R,
    2. Nishimura K,
    3. Nakai M
    ; J-ASPECT Study Collaborators, et al. Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin. Neurology 2018;90:e1143–e1149 doi:10.1212/WNL.0000000000005207 pmid:29490916
    CrossRefPubMed
  4. 4.↵
    1. Brouwers HB,
    2. Greenberg SM
    . Hematoma expansion following acute intracerebral hemorrhage. Cerebrovasc Dis 2013;35:195–201 doi:10.1159/000346599 pmid:23466430
    CrossRefPubMed
  5. 5.↵
    1. Li Q,
    2. Zhang G,
    3. Xiong X, et al
    . Black hole sign: novel imaging marker that predicts hematoma growth in patients with intracerebral hemorrhage. Stroke 2016;47:1777–81 doi:10.1161/STROKEAHA.116.013186 pmid:27174523
    Abstract/FREE Full Text
  6. 6.↵
    1. Li Q,
    2. Yang WS,
    3. Chen SL, et al
    . Black hole sign predicts poor outcome in patients with intracerebral hemorrhage. Cerebrovasc Dis 2018;45:48–53 doi:10.1159/000486163 pmid:29402824
    CrossRefPubMed
  7. 7.↵
    1. He GN,
    2. Guo HZ,
    3. Han X, et al
    . Comparison of CT black hole sign and other CT features in predicting hematoma expansion in patients with ICH. J Neurol 2018;265:1883–90 doi:10.1007/s00415-018-8932-6 pmid:29948249
    CrossRefPubMed
  8. 8.↵
    1. Kothari RU,
    2. Brott T,
    3. Broderick JP, et al
    . The ABCs of measuring intracerebral hemorrhage volumes. Stroke 1996;27:1304–05 doi:10.1161/01.str.27.8.1304 pmid:8711791
    Abstract/FREE Full Text
  9. 9.↵
    1. Dowlatshahi D,
    2. Demchuk AM,
    3. Flaherty ML
    ; VISTA Collaboration, et al. Defining hematoma expansion in intracerebral hemorrhage: relationship with patient outcomes. Neurology 2011;76:1238–44 doi:10.1212/WNL.0b013e3182143317 pmid:21346218
    Abstract/FREE Full Text
  10. 10.↵
    1. Wilson D,
    2. Charidimou A,
    3. Shakeshaft C
    ; CROMIS-2 Collaborators, et al. Volume and functional outcome of intracerebral hemorrhage according to oral anticoagulant type. Neurology 2016;86:360–66 doi:10.1212/WNL.0000000000002310 pmid:26718576
    Abstract/FREE Full Text
  11. 11.↵
    1. Hagii J,
    2. Tomita H,
    3. Metoki N, et al
    . Characteristics of intracerebral hemorrhage during rivaroxaban treatment: comparison with those during warfarin. Stroke 2014;45:2805–07 doi:10.1161/STROKEAHA.114.006661 pmid:25082810
    Abstract/FREE Full Text
  12. 12.↵
    1. von der Brelie C,
    2. Doukas A,
    3. Naumann R, et al
    . Clinical and radiological course of intracerebral haemorrhage associated with the new non-vitamin K anticoagulants. Acta Neurochir (Wien) 2017;159:101–09 doi:10.1007/s00701-016-3026-7 pmid:27873051
    CrossRefPubMed
  13. 13.↵
    1. Demchuk AM,
    2. Dowlatshahi D,
    3. Rodriguez-Luna D
    ; PREDICT/Sunnybrook ICH CTA Study Group, et al. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol 2012;11:307–14 doi:10.1016/S1474-4422(12)70038-8 pmid:22405630
    CrossRefPubMed
  14. 14.↵
    1. Fisher CM
    . Pathological observations in hypertensive cerebral hemorrhage. J Neuropathol Exp Neurol 1971;30:536–50 doi:10.1097/00005072-197107000-00015 pmid:4105427
    CrossRefPubMed
  15. 15.↵
    1. Barras CD,
    2. Tress BM,
    3. Christensen S
    ; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators, et al. Density and shape as CT predictors of intracerebral hemorrhage growth. Stroke 2009;40:1325–31 doi:10.1161/STROKEAHA.108.536888 pmid:19286590
    Abstract/FREE Full Text
  16. 16.↵
    1. Takeda R,
    2. Ogura T,
    3. Ooigawa H, et al
    . A practical prediction model for early hematoma expansion in spontaneous deep ganglionic intracerebral hemorrhage. Clin Neurol Neurosurg 2013;115:1028–31 doi:10.1016/j.clineuro.2012.10.016 pmid:23245855
    CrossRefPubMed
  17. 17.↵
    1. Brouwers HB,
    2. Chang Y,
    3. Falcone GJ, et al
    . Predicting hematoma expansion after primary intracerebral hemorrhage. JAMA Neurol 2014;71:158–64 doi:10.1001/jamaneurol.2013.5433 pmid:24366060
    CrossRefPubMed
  18. 18.↵
    1. Romero JM,
    2. Heit JJ,
    3. Delgado Almandoz JE, et al
    . Spot sign score predicts rapid bleeding in spontaneous intracerebral hemorrhage. Emerg Radiology 2012;19:195–202 doi:10.1007/s10140-012-1020-9 pmid:22271362
    CrossRefPubMed
  19. 19.↵
    1. Chen Y,
    2. Tian L,
    3. Wang L, et al
    . Black hole sign on noncontrast computed tomography in predicting hematoma expansion in patients with intracerebral hemorrhage: a meta-analysis. Curr Med Imaging 2020;16:878–86 doi:10.2174/1573405615666190903155738 pmid:33059557
    CrossRefPubMed
  20. 20.↵
    1. Li Q,
    2. Zhang G,
    3. Huang YJ, et al
    . Blend sign on computed tomography: novel and reliable predictor for early hematoma growth in patients with intracerebral hemorrhage. Stroke 2015;46:2119–23 doi:10.1161/STROKEAHA.115.009185 pmid:26089330
    Abstract/FREE Full Text
  21. 21.↵
    1. Li Q,
    2. Liu QJ,
    3. Yang WS, et al
    . Island sign: an imaging predictor for early hematoma expansion and poor outcome in patients with intracerebral hemorrhage. Stroke 2017;48:3019–25 doi:10.1161/STROKEAHA.117.017985 pmid:29018128
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 46 (3)
American Journal of Neuroradiology
Vol. 46, Issue 3
1 Mar 2025
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Cite this article
Hirotaka Sato, Manabu Kinoshita, Takuma Takano, Takahiro Sanada, Seiya Fujikawa, Masahiro Toda, Kiyoshi Choji, Teruo Kimura
Black Hole Sign under Anticoagulant Therapy: A Retrospective Comparison of Warfarin and Direct Oral Anticoagulants
American Journal of Neuroradiology Mar 2025, 46 (3) 489-494; DOI: 10.3174/ajnr.A8528

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Black Hole Sign: Oral Anticoagulants
Hirotaka Sato, Manabu Kinoshita, Takuma Takano, Takahiro Sanada, Seiya Fujikawa, Masahiro Toda, Kiyoshi Choji, Teruo Kimura
American Journal of Neuroradiology Mar 2025, 46 (3) 489-494; DOI: 10.3174/ajnr.A8528
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