CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

A. Tietze; B. Bison; J. Engelhardt; T. Fenouil; D. Figarella-Branger; E. Goebell; J. Hakumäki; E. Koscielniak; L.E. Ludlow; D. Meyronet; P. Nyman; I. Øra; J. Pesola; T. Rauramaa; R.E. Reddingius; D. Samuel; A. Sexton-Oates; A. Vasiljevic; A.K. Wefers; J. Zamecnik; D.T.W. Jones; M.K. Keck; K. von Hoff; European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group

doi:10.3174/ajnr.A8496

Research ArticlePediatric Neuroimaging

CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff and European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group

American Journal of Neuroradiology March 2025, 46 (3) 536-543; DOI: https://doi.org/10.3174/ajnr.A8496

A. Tietze

aFrom the Institute of Neuroradiology (A.T.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany

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B. Bison

bDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Augsburg, Germany

cFaculty of Medicine (B.B.), Neuroradiological Reference Center for the pediatric brain tumor studies of the German Society of Pediatric Oncology and Hematology, University Augsburg, Augsburg, Germany

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J. Engelhardt

dService de Neurochirurgie B (J.E.), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

eUniversity Bordeaux (J.E.), Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France

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T. Fenouil

fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France

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D. Figarella-Branger

gInstitute Neurophysiopathol (D.F.-B.), Aix-Marseille University, APHM, CNRS, INP, centre hospitalier universitaire Timone, Service d’Anatomie Pathologique et de Neuropathologie, Marseille, France

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E. Goebell

hDepartment of Diagnostic and Interventional Neuroradiology (E.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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J. Hakumäki

iDepartment of Clinical Radiology (J.H.), Kuopio University Hospital, Kuopio, Finland

jInstitute of Clinical Medicine (J.H.), University of Eastern Finland, Kuopio, Finland

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E. Koscielniak

kDepartment of Pediatric Oncology/Hematology/Immunology (E.K.), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany

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L.E. Ludlow

lMurdoch Children’s Research Institute (L.E.L.), and Children’s Cancer Centre (L.E.L.), The Royal Children’s Hospital, Parkville, Victoria, Australia

mDepartment of Paediatrics (L.E.L.), The University of Melbourne, Parkville, Victoria, Australia

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D. Meyronet

fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France

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P. Nyman

nCrown Princess Victoria Children´s Hospital (P.N.), Linköping University Hospital, Linköping, Sweden

oDepartment of Biomedical and Clinical Sciences (P.N.), Linköping University, Linköping, Sweden

pClinical Sciences, Pediatric Oncology and Hematology (I.O.), Lund University, Lund, Sweden

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I. Øra

qDepartment of Pediatrics (J.P.), Pediatric Hematology and Oncology Ward, Kuopio University Hospital, Kuopio, Finland

rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland

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J. Pesola

rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland

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T. Rauramaa

rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland

sDepartment of Clinical Pathology (T.R.), Kuopio University Hospital, Kuopio, Finland

tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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R.E. Reddingius

tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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D. Samuel

vDepartment of Pediatric Hematology-Oncology (D.S.), Valley Children’s Hospital, Madera, California

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A. Sexton-Oates

wRare Cancers Genomics Team (A.S.-O.), Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France

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A. Vasiljevic

fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France

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A.K. Wefers

xInstitute of Neuropathology (A.K.W.), and Mildred Scheel Cancer Career Center HaTriCS4 (A.K.W.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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J. Zamecnik

yDepartment of Pathology and Molecular Medicine (J.Z.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

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D.T.W. Jones

zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany

bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany

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M.K. Keck

zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany

bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany

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K. von Hoff

ccDepartment of Pediatric Oncology and Hematology (K.v.H.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany

ddDepartment of Paediatric and Adolescent Medicine (K.v.H.), Aarhus University Hospital, Aarhus, Denmark

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eeCollaborators from the European Society for Paediatric Oncology (SIOPE)

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A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group

CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

American Journal of Neuroradiology Mar 2025, 46 (3) 536-543; DOI: 10.3174/ajnr.A8496

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New CNS Embryonal Tumor Insights via MRI Analysis

A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group

American Journal of Neuroradiology Mar 2025, 46 (3) 536-543; DOI: 10.3174/ajnr.A8496

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Comparative Clinical and Imaging‐Based Evaluation of Therapeutic Modalities in CNS Embryonal Tumours With PLAGL Amplification

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CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

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