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Research ArticleMolecular Neuroimaging/Nuclear Medicine

Accuracy and Longitudinal Consistency of PET/MR Attenuation Correction in Amyloid PET Imaging amid Software and Hardware Upgrades

Chunwei Ying, Yasheng Chen, Yan Yan, Shaney Flores, Richard Laforest, Tammie L.S. Benzinger and Hongyu An
American Journal of Neuroradiology March 2025, 46 (3) 635-642; DOI: https://doi.org/10.3174/ajnr.A8490
Chunwei Ying
aFrom the Mallinckrodt Institute of Radiology (C.Y., S.F., R.L., T.L.S.B., H.U.), Washington University School of Medicine, St. Louis, Missouri
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Yasheng Chen
bDepartment of Neurology (Y.C., H.A.), Washington University School of Medicine, St. Louis, Missouri
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Yan Yan
cDepartment of Surgery (Y.Y., T.L.S.B.), Washington University School of Medicine, St. Louis, Missouri
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Shaney Flores
aFrom the Mallinckrodt Institute of Radiology (C.Y., S.F., R.L., T.L.S.B., H.U.), Washington University School of Medicine, St. Louis, Missouri
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Richard Laforest
aFrom the Mallinckrodt Institute of Radiology (C.Y., S.F., R.L., T.L.S.B., H.U.), Washington University School of Medicine, St. Louis, Missouri
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Tammie L.S. Benzinger
aFrom the Mallinckrodt Institute of Radiology (C.Y., S.F., R.L., T.L.S.B., H.U.), Washington University School of Medicine, St. Louis, Missouri
dKnight Alzheimer Disease Research Center (T.L.S.B.), Washington University School of Medicine, St. Louis, Missouri
eDepartment of Neurosurgery (T.L.S.B.), Washington University School of Medicine, St. Louis, Missouri
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Hongyu An
aFrom the Mallinckrodt Institute of Radiology (C.Y., S.F., R.L., T.L.S.B., H.U.), Washington University School of Medicine, St. Louis, Missouri
bDepartment of Neurology (Y.C., H.A.), Washington University School of Medicine, St. Louis, Missouri
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References

  1. 1.↵
    1. Jagust WJ,
    2. Bandy D,
    3. Chen K, et al
    ; Alzheimer’s Disease Neuroimaging Initiative. The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core. Alzheimers Dement 2010;6:221–29 doi:10.1016/j.jalz.2010.03.003 pmid:20451870
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. McKay NS,
    2. Gordon BA,
    3. Hornbeck RC, et al
    . Neuroimaging within the Dominantly Inherited Alzheimer’s Network (DIAN): PET and MRI. bioRxiv 20222022.2003. 2025.485799 https://www.biorxiv.org/content/10.1101/2022.03.25.485799v1. Accessed, March 30, 2022.
  3. 3.↵
    1. Sims JR,
    2. Zimmer JA,
    3. Evans CD, et al
    ; TRAILBLAZER-ALZ 2 Investigators. Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 Randomized Clinical Trial. JAMA 2023;330:512–27 doi:10.1001/jama.2023.13239
    CrossRefPubMed
  4. 4.↵
    1. Budd Haeberlein S,
    2. Aisen PS,
    3. Barkhof F, et al
    . Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease. J Prev Alzheimers Dis 2022;9:197–210
    CrossRefPubMed
  5. 5.↵
    1. van Dyck CH,
    2. Swanson CJ,
    3. Aisen P, et al
    . Lecanemab in early Alzheimer’s disease. N Engl J Med 2023;388:9–21 doi:10.1056/NEJMoa2212948 pmid:36449413
    CrossRefPubMed
  6. 6.↵
    1. Jang H,
    2. Liu F,
    3. Zhao G, et al
    . Technical note: deep learning based MRAC using rapid ultrashort echo time imaging. Med Phys 2018;45:3697–704 doi:10.1002/mp.12964
    CrossRefPubMed
  7. 7.↵
    1. Shiri I,
    2. Ghafarian P,
    3. Geramifar P, et al
    . Direct attenuation correction of brain PET images using only emission data via a deep convolutional encoder-decoder (Deep-DAC). Eur Radiology 2019;29:6867–79 doi:10.1007/s00330-019-06229-1 pmid:31227879
    CrossRefPubMed
  8. 8.↵
    1. Liu F,
    2. Jang H,
    3. Kijowski R, et al
    . Deep learning MR imaging-based attenuation correction for PET/MR imaging. Radiology 2018;286:676–84 doi:10.1148/radiol.2017170700 pmid:28925823
    CrossRefPubMed
  9. 9.↵
    1. Chen Y,
    2. Ying C,
    3. Binkley MM, et al
    . Deep learning-based T1-enhanced selection of linear attenuation coefficients (DL-TESLA) for PET/MR attenuation correction in dementia neuroimaging. Magn Reson Med 2021;86:499–513 doi:10.1002/mrm.28689
    CrossRefPubMed
  10. 10.↵
    1. Ladefoged CN,
    2. Hansen AE,
    3. Henriksen OM, et al
    . AI-driven attenuation correction for brain PET/MRI: clinical evaluation of a dementia cohort and importance of the training group size. Neuroimage 2020;222:117221 doi:10.1016/j.neuroimage.2020.117221
    CrossRefPubMed
  11. 11.↵
    1. Gong K,
    2. Han PK,
    3. Johnson KA, et al
    . Attenuation correction using deep learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging. Eur J Nucl Med Mol Imaging 2021;48:1351–61 doi:10.1007/s00259-020-05061-w
    CrossRefPubMed
  12. 12.↵
    1. Gong K,
    2. Yang J,
    3. Kim K, et al
    . Attenuation correction for brain PET imaging using deep neural network based on Dixon and ZTE MR images. Phys Med Biol 2018;63:125011 doi:10.1088/1361-6560/aac763 pmid:29790857
    CrossRefPubMed
  13. 13.↵
    1. Arabi H,
    2. Zeng G,
    3. Zheng G, et al
    . Novel adversarial semantic structure deep learning for MRI-guided attenuation correction in brain PET/MRI. Eur J Nucl Med Mol Imaging 2019;46:2746–59 doi:10.1007/s00259-019-04380-x pmid:31264170
    CrossRefPubMed
  14. 14.↵
    1. Gong K,
    2. Yang J,
    3. Larson PEZ, et al
    . MR-based attenuation correction for brain PET using 3D cycle-consistent adversarial network. IEEE Trans Radiat Plasma Med Sci 2021;5:185–92 doi:10.1109/trpms.2020.3006844 pmid:33778235
    CrossRefPubMed
  15. 15.↵
    1. Leynes AP,
    2. Ahn S,
    3. Wangerin KA, et al
    . Attenuation coefficient estimation for PET/MRI with Bayesian deep learning pseudo-CT and maximum-likelihood estimation of activity and attenuation. IEEE Trans Radiat Plasma Med Sci 2022;6:678–89 doi:10.1109/TRPMS.2021.3118325
    CrossRefPubMed
  16. 16.↵
    1. Landau SM,
    2. Fero A,
    3. Baker SL, et al
    . Measurement of longitudinal beta-amyloid change with 18F-florbetapir PET and standardized uptake value ratios. J Nucl Med 2015;56:567–74 doi:10.2967/jnumed.114.148981
    Abstract/FREE Full Text
  17. 17.↵
    1. Jack CR, Jr.,
    2. Wiste HJ,
    3. Lesnick TG, et al
    . Brain beta-amyloid load approaches a plateau. Neurology 2013;80:890–96 doi:10.1212/WNL.0b013e3182840bbe
    Abstract/FREE Full Text
  18. 18.↵
    1. Joshi AD,
    2. Pontecorvo MJ,
    3. Clark CM, et al
    ; Florbetapir F 18 Study Investigators. Performance characteristics of amyloid PET with florbetapir F 18 in patients with Alzheimer’s disease and cognitively normal subjects. J Nucl Med 2012;53:378–84 doi:10.2967/jnumed.111.090340 pmid:22331215
    Abstract/FREE Full Text
  19. 19.↵
    1. Vandenberghe R,
    2. Van Laere K,
    3. Ivanoiu A, et al
    . 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial. Ann Neurol 2010;68:319–29 doi:10.1002/ana.22068 pmid:20687209
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Brendel M,
    2. Hogenauer M,
    3. Delker A, et al
    ; Alzheimer’s Disease Neuroimaging Initiative. Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction. Neuroimage 2015;108:450–59 doi:10.1016/j.neuroimage.2014.11.055 pmid:25482269
    CrossRefPubMed
  21. 21.↵
    1. Chen K,
    2. Roontiva A,
    3. Thiyyagura P, et al
    ; Alzheimer’s Disease Neuroimaging Initiative. Improved power for characterizing longitudinal amyloid-beta PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region. J Nucl Med 2015;56:560–66 doi:10.2967/jnumed.114.149732
    Abstract/FREE Full Text
  22. 22.↵
    1. Smith AM,
    2. Obuchowski NA,
    3. Foster NL, et al
    . The RSNA QIBA profile for amyloid PET as an imaging biomarker for cerebral amyloid quantification. J Nucl Med 2023;64:294–303 doi:10.2967/jnumed.122.264031
    Abstract/FREE Full Text
  23. 23.↵
    1. Zhang Y,
    2. Brady M,
    3. Smith S
    . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57 doi:10.1109/42.906424
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Otsu N
    . A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern 1979;9:62–66 doi:10.1109/TSMC.1979.4310076
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Jenkinson M,
    2. Smith S
    . A global optimisation method for robust affine registration of brain images. Med Image Anal 2001;5:143–56 doi:10.1016/s1361-8415(01)00036-6 pmid:11516708
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Carney JP,
    2. Townsend DW,
    3. Rappoport V, et al
    . Method for transforming CT images for attenuation correction in PET/CT imaging. Med Phys 2006;33:976–83 doi:10.1118/1.2174132
    CrossRefPubMed
  27. 27.↵
    1. Avants BB,
    2. Tustison NJ,
    3. Song G, et al
    . A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage 2011;54:2033–44 doi:10.1016/j.neuroimage.2010.09.025 pmid:20851191
    CrossRefPubMed
  28. 28.↵
    1. Fonov VS,
    2. Evans AC,
    3. McKinstry RC, et al
    . Unbiased nonlinear average age-appropriate brain templates from birth to adulthood. Neuroimage 2009;47:S102 doi:10.1016/S1053-8119(09)70884-5
    CrossRef
  29. 29.↵
    1. Landau S,
    2. Jagust W
    . Florbetapir Processing Methods. Los Angeles: Alzheimer’s Disease Neuroimaging Institute; 2015.
  30. 30.↵
    1. Albrecht DS,
    2. Sagare A,
    3. Pachicano M, et al
    . Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Brain Behav Immun 2021;94:299–307 doi:10.1016/j.bbi.2021.01.010 pmid:33486003
    CrossRefPubMed
  31. 31.↵
    1. Kolibash S,
    2. Minhas D,
    3. Lopresti B
    . Centiloid Level-2 Analysis of [18F] Florbetaben (FBB) and [18F] Florbetapir (FBP) PET Image Data using the ADNI Pipeline. Centiloid Level-2 Analysis of [18F] Florbetaben (FBB) and [18F] Florbetapir (FBP) PET Image Data using the ADNI Pipeline
  32. 32.↵
    1. Catana C,
    2. Laforest R,
    3. An H, et al
    . A path to qualification of PET/MRI scanners for multicenter brain imaging studies: evaluation of MRI-based attenuation correction methods using a patient phantom. J Nucl Med 2022;63:615–21 doi:10.2967/jnumed.120.261881 pmid:34301784
    Abstract/FREE Full Text
  33. 33.↵
    1. Bland MJ,
    2. Altman D
    . Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;327:307–10 doi:10.1016/S0140-6736(86)90837-8
    CrossRefPubMed
  34. 34.↵
    1. Koo TK,
    2. Li MY
    . A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 2016;15:155–63 doi:10.1016/j.jcm.2016.02.012 pmid:27330520
    CrossRefPubMed
  35. 35.↵
    1. Liu Y,
    2. Chen A,
    3. Shi H, et al
    . CT synthesis from MRI using multi-cycle GAN for head-and-neck radiation therapy. Comput Med Imaging Graph 2021;91:101953 doi:10.1016/j.compmedimag.2021.101953
    CrossRefPubMed
  36. 36.↵
    1. Chen KT,
    2. Izquierdo-Garcia D,
    3. Poynton CB, et al
    . On the accuracy and reproducibility of a novel probabilistic atlas-based generation for calculation of head attenuation maps on integrated PET/MR scanners. Eur J Nucl Med Mol Imaging 2017;44:398–407 doi:10.1007/s00259-016-3489-z
    CrossRefPubMed
  37. 37.↵
    1. Klunk WE,
    2. Koeppe RA,
    3. Price JC, et al
    . The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers Dement 2015;11:1–15.e11-14 doi:10.1016/j.jalz.2014.07.003
    CrossRefPubMed
  38. 38.↵
    1. Chen CD,
    2. McCullough A,
    3. Gordon B
    ; DIAN-TU Study Team, et al. Longitudinal head-to-head comparison of (11)C-PiB and (18)F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-beta monoclonal antibodies in dominantly inherited Alzheimer’s disease. Eur J Nucl Med Mol Imaging 2023;50:2669–82 doi:10.1007/s00259-023-06209-0 pmid:37017737
    CrossRefPubMed
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Chunwei Ying, Yasheng Chen, Yan Yan, Shaney Flores, Richard Laforest, Tammie L.S. Benzinger, Hongyu An
Accuracy and Longitudinal Consistency of PET/MR Attenuation Correction in Amyloid PET Imaging amid Software and Hardware Upgrades
American Journal of Neuroradiology Mar 2025, 46 (3) 635-642; DOI: 10.3174/ajnr.A8490

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PET/MR AC Accuracy in Amyloid Imaging
Chunwei Ying, Yasheng Chen, Yan Yan, Shaney Flores, Richard Laforest, Tammie L.S. Benzinger, Hongyu An
American Journal of Neuroradiology Mar 2025, 46 (3) 635-642; DOI: 10.3174/ajnr.A8490
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