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Research ArticlePEDIATRIC NEUROIMAGING

Single Large-Scale Mitochondrial Deletion Syndromes: Neuroimaging Phenotypes and Longitudinal Progression in Pediatric Patients

Cesar A.P.F. Alves, Maria Camilla Rossi-Espagnet, Francisco Perez, Amirreza Manteghinejad, James T. Peterson, Rebecca Ganetzky, Antonio Napolitano, Francesco Grassi, Ibrahim George-Sankoh, Harun Yildiz, Colleen Muraresku, Marni J. Falk, Diego Martinelli, Daniela Longo, Adeline Vanderver, Carlo Gandolfo, Russell P. Saneto, Amy Goldstein and Arastoo Vossough
American Journal of Neuroradiology May 2025, DOI: https://doi.org/10.3174/ajnr.A8670
Cesar A.P.F. Alves
aFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., A.M., A. Vossough), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
bDivision of Neuroradiology, Department of Radiology (C.A.P.F.A.), The Boston Children’s Hospital-Harvard Medical School, Boston, Massachusetts
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Maria Camilla Rossi-Espagnet
mDiagnostic and Interventional Neuroradiology Unit (M.C.R.-E., D.L., C.G.) Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Francisco Perez
dDivision of Neuroradiology, Department of Radiology (F.P.), Texas Children’s Hospital, Houston, Texas
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Amirreza Manteghinejad
aFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., A.M., A. Vossough), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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James T. Peterson
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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Rebecca Ganetzky
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
lDepartments of Pediatrics (R.G., C.M., M.J.F., A.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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Antonio Napolitano
fMedical Physics Unit (A.N., F.G.), Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Francesco Grassi
fMedical Physics Unit (A.N., F.G.), Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Ibrahim George-Sankoh
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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Harun Yildiz
gDepartment of Radiology (H.Y.), Bursa Dortcelik Children’s Hospital, Turkey
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Colleen Muraresku
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
lDepartments of Pediatrics (R.G., C.M., M.J.F., A.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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Marni J. Falk
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
lDepartments of Pediatrics (R.G., C.M., M.J.F., A.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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Diego Martinelli
hDivision of Metabolism (D.M.), Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Daniela Longo
mDiagnostic and Interventional Neuroradiology Unit (M.C.R.-E., D.L., C.G.) Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Adeline Vanderver
iDivision of Neurology (A. Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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Carlo Gandolfo
cFunctional and Interventional Neuroimaging Unit (C.G.), Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
mDiagnostic and Interventional Neuroradiology Unit (M.C.R.-E., D.L., C.G.) Bambino Gesù Children’s Hospital, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
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Russell P. Saneto
kDivision of Pediatric Neurology (R.P.S.), Seattle Children’s Hospital, University of Washington, Seattle, Washington.
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Amy Goldstein
eMitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics (J.T.P., R.G., I.G.-S., C.M., M.J.F., A.G.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
lDepartments of Pediatrics (R.G., C.M., M.J.F., A.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
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Arastoo Vossough
aFrom the Division of Neuroradiology, Department of Radiology (C.A.P.F.A., A.M., A. Vossough), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
jDepartments of Pediatrics and Radiology (A. Vossough), Perelman School of Medicine University of Pennsylvania, Philadelphia, Pennsylvania
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References

  1. 1.↵
    1. Björkman K,
    2. Vissing J,
    3. Østergaard E, et al
    . Phenotypic spectrum and clinical course of single large-scale mitochondrial DNA deletion disease in the paediatric population: a multicentre study. J Med Genet 2023;60:65–73 doi:10.1136/jmedgenet-2021-108006 pmid:34872991
    Abstract/FREE Full Text
  2. 2.↵
    1. Reynolds E,
    2. Byrne M,
    3. Ganetzky R, et al
    . Pediatric single large-scale mtDNA deletion syndromes: the power of patient reported outcomes. Mol Genet Metab 2021;134:301–08 doi:10.1016/j.ymgme.2021.11.004 pmid:34862134
    CrossRefPubMed
  3. 3.↵
    1. Adam MP,
    2. Feldman J,
    3. Mirzaa GM, et al.
    1. Goldstein A,
    2. Falk MJ
    . Single large-scale mitochondrial DNA deletion syndromes. 2003 Dec 17 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301382.
  4. 4.↵
    1. Broomfield A,
    2. Sweeney MG,
    3. Woodward CE, et al
    . Paediatric single mitochondrial DNA deletion disorders: an overlapping spectrum of disease. J Inherit Metab Dis 2015;38:445–57 doi:10.1007/s10545-014-9778-4 pmid:25352051
    CrossRefPubMed
  5. 5.↵
    1. Gustafson MA,
    2. McCormick EM,
    3. Perera L, et al
    . Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes. PLoS One 2019;14:e0221829 doi:10.1371/journal.pone.0221829 pmid:31479473
    CrossRefPubMed
  6. 6.↵
    1. Alves CAPF,
    2. Teixeira SR,
    3. Martin-Saavedra JS, et al
    . Pediatric Leigh syndrome: neuroimaging features and genetic correlations. Ann Neurol 2020;88:218–32 doi:10.1002/ana.25789 pmid:32445240
    CrossRefPubMed
  7. 7.↵
    1. Yoshimi A,
    2. Ishikawa K,
    3. Niemeyer C, et al
    . Pearson syndrome: a multisystem mitochondrial disease with bone marrow failure. Orphanet J Rare Dis 2022;17:379 doi:10.1186/s13023-022-02538-9 pmid:36253820
    CrossRefPubMed
  8. 8.↵
    1. Mancuso M,
    2. Orsucci D,
    3. Angelini C, et al
    . Redefining phenotypes associated with mitochondrial DNA single deletion. J Neurol 2015;262:1301–09 doi:10.1007/s00415-015-7710-y pmid:25808502
    CrossRefPubMed
  9. 9.↵
    1. Grady JP,
    2. Campbell G,
    3. Ratnaike T, et al
    . Disease progression in patients with single, large-scale mitochondrial DNA deletions. Brain 2014;137:323–34 doi:10.1093/brain/awt321 pmid:24277717
    CrossRefPubMed
  10. 10.↵
    1. Holt IJ,
    2. Harding AE,
    3. Cooper JM, et al
    . Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA. Ann Neurol 1989;26:699–708 doi:10.1002/ana.410260603 pmid:2604380
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Moraes CT,
    2. DiMauro S,
    3. Zeviani M, et al
    . Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. N Engl J Med 1989;320:1293–99 doi:10.1056/NEJM198905183202001 pmid:2541333
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Rötig A,
    2. Bourgeron T,
    3. Chretien D, et al
    . Spectrum of mitochondrial DNA rearrangements in the Pearson marrow-pancreas syndrome. Hum Mol Genet 1995;4:1327–30 doi:10.1093/hmg/4.8.1327 pmid:7581370
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Chu BC,
    2. Terae S,
    3. Takahashi C, et al
    . MRI of the brain in the Kearns-Sayre syndrome: report of four cases and a review. Neuroradiology 1999;41:759–64 doi:10.1007/s002340050838 pmid:10552027
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Yu M,
    2. Zhang Z,
    3. Wang Q-Q, et al
    . Clinical and brain magnetic resonance imaging features in a cohort of Chinese patients with Kearns-Sayre syndrome. Chin Med J (Engl) 2016;129:1419–24 doi:10.4103/0366-6999.183417 pmid:27270536
    CrossRefPubMed
  15. 15.↵
    1. Saneto RP,
    2. Friedman SD,
    3. Shaw DWW
    . Neuroimaging of mitochondrial disease. Mitochondrion 2008;8:396–413 doi:10.1016/j.mito.2008.05.003 pmid:18590986
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Alves CAPF,
    2. Zandifar A,
    3. Peterson JT, et al
    . MELAS: phenotype classification into classic-versus-atypical presentations. AJNR Am J Neuroradiol 2023;44:602–10 doi:10.3174/ajnr.A7837 pmid:37024306
    Abstract/FREE Full Text
  17. 17.↵
    1. von Elm E,
    2. Altman DG,
    3. Egger M, et al
    ; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453–57 doi:10.1016/S0140-6736(07)61602-X pmid:18064739
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Luca P,
    2. Alessia G,
    3. Camilla R-EM, et al
    . Spinal cord involvement in Kearns-Sayre syndrome: a neuroimaging study. Neuroradiology 2020;62:1315–21 doi:10.1007/s00234-020-02501-0 pmid:32700106
    CrossRefPubMed
  19. 19.↵
    1. Balci TB,
    2. Hartley T,
    3. Xi Y, et al
    ; Care4Rare Canada Consortium. Debunking Occam’s razor: diagnosing multiple genetic diseases in families by whole-exome sequencing. Clin Genet 2017;92:281–89 doi:10.1111/cge.12987 pmid:28170084
    CrossRefPubMed
  20. 20.↵
    1. van der Voorn JP,
    2. Pouwels PJW,
    3. Kamphorst W, et al
    . Histopathologic correlates of radial stripes on MR images in lysosomal storage disorders. AJNR Am J Neuroradiol 2005;26:442–46 pmid:15760847
    PubMedWeb of Science
  21. 21.↵
    1. Fourati H,
    2. Ellouze E,
    3. Ahmadi M, et al
    . MRI features in 17 patients with l2 hydroxyglutaric aciduria. Eur J Radiol Open 2016;3:245–50 doi:10.1016/j.ejro.2016.09.001 pmid:27709120
    CrossRefPubMed
  22. 22.↵
    1. Sferruzza G,
    2. Del Bondio A,
    3. Citterio A, et al
    . U-fiber leukoencephalopathy due to a novel mutation in the gene. Neurol Genet 2021;7:e573 doi:10.1212/NXG.0000000000000573 pmid:33709035
    Abstract/FREE Full Text
  23. 23.↵
    1. Sakai Y,
    2. Kira R,
    3. Torisu H, et al
    . Persistent diffusion abnormalities in the brainstem of three children with mitochondrial diseases. AJNR Am J Neuroradiol 2006;27:1924–26 pmid:17032867
    PubMedWeb of Science
  24. 24.↵
    1. Brown GK,
    2. Squier MV
    . Neuropathology and pathogenesis of mitochondrial diseases. J Inherit Metab Dis 1996;19:553–72 doi:10.1007/BF01799116 pmid:8884579
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Alves CAPF,
    2. Goldstein A,
    3. Teixeira SR, et al
    . Involvement of the spinal cord in primary mitochondrial disorders: a neuroimaging mimicker of inflammation and ischemia in children. AJNR Am J Neuroradiol 2021;42:389–96 doi:10.3174/ajnr.A6910 pmid:33384291
    Abstract/FREE Full Text
  26. 26.↵
    1. Parikh S,
    2. Saneto R,
    3. Falk MJ, et al
    . A modern approach to the treatment of mitochondrial disease. Curr Treat Options Neurol 2009;11:414–30 doi:10.1007/s11940-009-0046-0 pmid:19891905
    CrossRefPubMed
  27. 27.↵
    1. Rossi-Espagnet MC,
    2. Lucignani M,
    3. Pasquini L, et al
    . Visual pathways evaluation in Kearns Sayre syndrome: a diffusion tensor imaging study. Neuroradiology 2020;62:241–49 doi:10.1007/s00234-019-02302-0 pmid:31680196
    CrossRefPubMed
  28. 28.↵
    1. Mancuso M, and
    2. Klopstock T.
    1. Alves CAPF,
    2. Teixeira SR,
    3. Goncalves FG, et al
    . Neuroimaging findings in primary mitochondrial cytopathies. In: Diagnosis and Management of Mitochondrial Disorders. Eds: Mancuso M, and Klopstock T. Springer-Verlag International Publishing; 2019:289–316
  29. 29.↵
    1. Gonçalves FG,
    2. Alves CAPF,
    3. Heuer B, et al
    . Primary mitochondrial disorders of the pediatric central nervous system: neuroimaging findings. Radiographics 2020;40:2042–67 doi:10.1148/rg.2020200052 pmid:33136487
    CrossRefPubMed
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Cesar A.P.F. Alves, Maria Camilla Rossi-Espagnet, Francisco Perez, Amirreza Manteghinejad, James T. Peterson, Rebecca Ganetzky, Antonio Napolitano, Francesco Grassi, Ibrahim George-Sankoh, Harun Yildiz, Colleen Muraresku, Marni J. Falk, Diego Martinelli, Daniela Longo, Adeline Vanderver, Carlo Gandolfo, Russell P. Saneto, Amy Goldstein, Arastoo Vossough
Single Large-Scale Mitochondrial Deletion Syndromes: Neuroimaging Phenotypes and Longitudinal Progression in Pediatric Patients
American Journal of Neuroradiology May 2025, DOI: 10.3174/ajnr.A8670

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Neuroimaging Delineation and Progression of SLSMD
Cesar A.P.F. Alves, Maria Camilla Rossi-Espagnet, Francisco Perez, Amirreza Manteghinejad, James T. Peterson, Rebecca Ganetzky, Antonio Napolitano, Francesco Grassi, Ibrahim George-Sankoh, Harun Yildiz, Colleen Muraresku, Marni J. Falk, Diego Martinelli, Daniela Longo, Adeline Vanderver, Carlo Gandolfo, Russell P. Saneto, Amy Goldstein, Arastoo Vossough
American Journal of Neuroradiology May 2025, DOI: 10.3174/ajnr.A8670
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