Whole-Brain N-Acetylaspartate Concentration: Correlation with T2-Weighted Lesion Volume and Expanded Disability Status Scale Score in Cases of Relapsing-Remitting Multiple Sclerosis

American Journal of Neuroradiology

Comparisons among whole-brain NAA, EDSS, lesion volume on T2-weighted images, and age

Criterion	P/r_S Value
Criterion	Age	EDSSScore	Lesion Volume
Whole-Brain NAA P/r_S	.1271/−0.2209	.9852/−0.0027	.7620/−0.0443
Age P/r_S	−/−	.5375/0.0912	.3717/0.1304
Expanded Disability Status Scale P/r_S	.5375/0.0912	−/−	.0434/0.2927

Note.—Statistics were calculated with non-parametric Spearman correlation coefficient (r_S) analysis, showing the P and r_S values. Results are significant at P < .05. Note a weak statistical significance only between T2 lesion volume and EDSS score (.0434), but the small associated r_S indicates that this correlation accounts for only approximately 10% of the variations in the data.