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OtherINTERVENTIONAL

Intraarterially Administered Abciximab as an Adjuvant Thrombolytic Therapy: Report of Three Cases

O-Ki Kwon, Ki Jae Lee, Moon Hee Han, Chang-Wan Oh, Dae Hee Han and Young Cho Koh
American Journal of Neuroradiology March 2002, 23 (3) 447-451;
O-Ki Kwon
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Ki Jae Lee
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Moon Hee Han
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Chang-Wan Oh
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Dae Hee Han
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Young Cho Koh
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    Fig 1.

    Case 1. Angiograms show an acute middle cerebral artery occlusion treated with intraarterially administered urokinase and abciximab.

    A, Initial angiogram shows occlusion of the left M1 segment.

    B, After the intraarterial infusion of urokinase (100,000 U), the artery is partially opened.

    C, Angiogram obtained after the intraarterial infusion of urokinase (300,000 U) shows aggravation of thrombotic occlusion of the M1 segment.

    D, Angiogram obtained 5 minutes after intraarterial infusion of 10 mg of abciximab shows a partial recanalization. Remaining thrombi are seen within the superior division of the middle cerebral artery.

    E, Angiogram obtained another 5 minutes later shows more advanced recanalization.

    F, Final angiogram shows further recanalization. Although one branch of the inferior division of the middle cerebral artery is still occluded, in lateral projection, there was no missing artery owing to well-developed collaterals (not shown).

  • Fig 2.
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    Fig 2.

    Case 2. Angiograms show a thrombotic complication that occurred during embolization with Guglielmi detachable coils; this was successfully treated with intraarterial abciximab.

    A, Angiogram shows a bilobulated posterior communicating artery aneurysm.

    B, Angiogram obtained after detachment of the last coil shows thrombotic occlusion of the parent artery.

    C, Angiogram obtained 5 minutes after intraarterial infusion of abciximab (5 mg) through a guide catheter shows recanalization, although there remains a luminal narrowing of the parent artery due to the protruding coil mass.

  • Fig 3.
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    Fig 3.

    Case 3. Angiograms show a thrombotic complication that occurred during embolization with Guglielmi detachable coils; this was successfully treated with intraarterially administered abciximab.

    A, Initial angiogram shows an anterior communicating artery aneurysm.

    B, Angiogram obtained after complete occlusion with five Guglielmi detachable coils shows luminal narrowings of both A2 segments.

    C, Angiogram obtained 15 minutes after intraarterial infusion of abciximab (4 mg) by means of a microcatheter shows an obvious thrombolysis. Bloodflow through the right A2 segment is completely restored.

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American Journal of Neuroradiology: 23 (3)
American Journal of Neuroradiology
Vol. 23, Issue 3
1 Mar 2002
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Cite this article
O-Ki Kwon, Ki Jae Lee, Moon Hee Han, Chang-Wan Oh, Dae Hee Han, Young Cho Koh
Intraarterially Administered Abciximab as an Adjuvant Thrombolytic Therapy: Report of Three Cases
American Journal of Neuroradiology Mar 2002, 23 (3) 447-451;

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Intraarterially Administered Abciximab as an Adjuvant Thrombolytic Therapy: Report of Three Cases
O-Ki Kwon, Ki Jae Lee, Moon Hee Han, Chang-Wan Oh, Dae Hee Han, Young Cho Koh
American Journal of Neuroradiology Mar 2002, 23 (3) 447-451;
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  • Guidelines for the Early Management of Patients With Ischemic Stroke: 2005 Guidelines Update A Scientific Statement From the Stroke Council of the American Heart Association/American Stroke Association
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