Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticlePediatrics

Reduced Cortical Thickness in Children with New-Onset Seizures

E. Widjaja, S. Zarei Mahmoodabadi, C. Go, C. Raybaud, S. Chuang, O.C. Snead and M.L. Smith
American Journal of Neuroradiology April 2012, 33 (4) 673-677; DOI: https://doi.org/10.3174/ajnr.A2982
E. Widjaja
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Zarei Mahmoodabadi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Go
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Raybaud
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Chuang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O.C. Snead
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.L. Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Lawson JA,
    2. Cook MJ,
    3. Bleasel AF,
    4. et al
    . Quantitative MRI in outpatient childhood epilepsy. Epilepsia 1997;38: 1289–93
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Lawson JA,
    2. Nguyen W,
    3. Bleasel AF,
    4. et al
    . ILAE-defined epilepsy syndromes in children: correlation with quantitative MRI. Epilepsia 1998;39: 1345–49
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Lawson JA,
    2. Vogrin S,
    3. Bleasel AF,
    4. et al
    . Predictors of hippocampal, cerebral, and cerebellar volume reduction in childhood epilepsy. Epilepsia 2000;41: 1540–45
    CrossRefPubMed
  4. 4.↵
    1. Lawson JA,
    2. Vogrin S,
    3. Bleasel AF,
    4. et al
    . Cerebral and cerebellar volume reduction in children with intractable epilepsy. Epilepsia 2000;41: 1456–62
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Lawson JA,
    2. Cook MJ,
    3. Vogrin S,
    4. et al
    . Clinical, EEG, and quantitative MRI differences in pediatric frontal and temporal lobe epilepsy. Neurology 2002;58: 723–29
    Abstract/FREE Full Text
  6. 6.↵
    1. Mueller SG,
    2. Laxer KD,
    3. Barakos J,
    4. et al
    . Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis. Neuroimage 2009;46: 353–59
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. McDonald CR,
    2. Ahmadi ME,
    3. Hagler DJ,
    4. et al
    . Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy. Neurology 2008;71: 1869–76
    Abstract/FREE Full Text
  8. 8.↵
    1. Jack CR Jr.,
    2. Sharbrough FW,
    3. Cascino GD,
    4. et al
    . Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurol 1992;31: 138–46
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Quigg M,
    2. Bertram EH,
    3. Jackson T,
    4. et al
    . Volumetric magnetic resonance imaging evidence of bilateral hippocampal atrophy in mesial temporal lobe epilepsy. Epilepsia 1997;38: 588–94
    CrossRefPubMed
  10. 10.↵
    1. Woermann FG,
    2. Barker GJ,
    3. Birnie KD,
    4. et al
    . Regional changes in hippocampal T2 relaxation and volume: a quantitative magnetic resonance imaging study of hippocampal sclerosis. J Neurol Neurosurg Psychiatry 1998;65: 656–64
    Abstract/FREE Full Text
  11. 11.↵
    1. Tasch E,
    2. Cendes F,
    3. Li LM,
    4. et al
    . Neuroimaging evidence of progressive neuronal loss and dysfunction in temporal lobe epilepsy. Ann Neurol 1999;45: 568–76
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Kalviainen R,
    2. Salmenpera T,
    3. Partanen K,
    4. et al
    . MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy. Epilepsy Res 1997;28: 39–50
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Bernasconi N,
    2. Bernasconi A,
    3. Andermann F,
    4. et al
    . Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study. Neurology 1999;52: 1870–76
    Abstract/FREE Full Text
  14. 14.↵
    1. DeCarli C,
    2. Hatta J,
    3. Fazilat S,
    4. et al
    . Extratemporal atrophy in patients with complex partial seizures of left temporal origin. Ann Neurol 1998;43: 41–45
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Marsh L,
    2. Morrell MJ,
    3. Shear PK,
    4. et al
    . Cortical and hippocampal volume deficits in temporal lobe epilepsy. Epilepsia 1997;38: 576–87
    CrossRefPubMed
  16. 16.↵
    1. Sandok EK,
    2. O'Brien TJ,
    3. Jack CR,
    4. et al
    . Significance of cerebellar atrophy in intractable temporal lobe epilepsy: a quantitative MRI study. Epilepsia 2000;41: 1315–20
    CrossRefPubMed
  17. 17.↵
    1. Betting LE,
    2. Mory SB,
    3. Li LM,
    4. et al
    . Voxel-based morphometry in patients with idiopathic generalized epilepsies. Neuroimage 2006;32: 498–502
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Betting LE,
    2. Mory SB,
    3. Lopes-Cendes I,
    4. et al
    . MRI volumetry shows increased anterior thalamic volumes in patients with absence seizures. Epilepsy Behav 2006;8: 575–80
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Betting LE,
    2. Mory SB,
    3. Lopes-Cendes I,
    4. et al
    . MRI reveals structural abnormalities in patients with idiopathic generalized epilepsy. Neurology 2006;67: 848–52
    Abstract/FREE Full Text
  20. 20.↵
    1. Pardoe H,
    2. Pell GS,
    3. Abbott DF,
    4. et al
    . Multi-site voxel-based morphometry: methods and a feasibility demonstration with childhood absence epilepsy. Neuroimage 2008;42: 611–16
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Pulsipher DT,
    2. Seidenberg M,
    3. Guidotti L,
    4. et al
    . Thalamofrontal circuitry and executive dysfunction in recent-onset juvenile myoclonic epilepsy. Epilepsia 2009;50: 1210–19
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Pringle CE,
    2. Blume WT,
    3. Munoz DG,
    4. et al
    . Pathogenesis of mesial temporal sclerosis. Can J Neurol Sci 1993;20: 184–93
    PubMedWeb of Science
  23. 23.↵
    1. Fastenau PS,
    2. Johnson CS,
    3. Perkins SM,
    4. et al
    . Neuropsychological status at seizure onset in children: risk factors for early cognitive deficits. Neurology 2009;73: 526–34
    Abstract/FREE Full Text
  24. 24.↵
    1. Hermann B,
    2. Jones J,
    3. Sheth R,
    4. et al
    . Children with new-onset epilepsy: neuropsychological status and brain structure. Brain 2006;129: 2609–19
    Abstract/FREE Full Text
  25. 25.↵
    1. Oostrom KJ,
    2. Smeets-Schouten A,
    3. Kruitwagen CL,
    4. et al
    . Not only a matter of epilepsy: early problems of cognition and behavior in children with “epilepsy only”—a prospective, longitudinal, controlled study starting at diagnosis. Pediatrics 2003;112: 1338–44
    Abstract/FREE Full Text
  26. 26.↵
    1. Berg AT,
    2. Smith SN,
    3. Frobish D,
    4. et al
    . Special education needs of children with newly diagnosed epilepsy. Dev Med Child Neurol 2005;47: 749–53
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Fischl B,
    2. Sereno MI,
    3. Tootell RB,
    4. et al
    . High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 1999;8: 272–84
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Fischl B,
    2. Sereno MI,
    3. Dale AM
    . Cortical surface-based analysis. II. Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999;9: 195–207
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Fischl B,
    2. Dale AM
    . Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 2000;97: 11050–55
    Abstract/FREE Full Text
  30. 30.↵
    1. Fischl B,
    2. Liu A,
    3. Dale AM
    . Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 2001;20: 70–80
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Fischl B,
    2. Salat DH,
    3. Busa E,
    4. et al
    . Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002;33: 341–55
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Fischl B,
    2. van der Kouwe A,
    3. Destrieux C,
    4. et al
    . Automatically parcellating the human cerebral cortex. Cereb Cortex 2004;14: 11–22
    Abstract/FREE Full Text
  33. 33.↵
    1. Dale AM,
    2. Fischl B,
    3. Sereno MI
    . Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999;9: 179–94
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Segonne F,
    2. Grimson E,
    3. Fischl B
    . A genetic algorithm for the topology correction of cortical surfaces. Inf Process Med Imaging 2005;19: 393–405
    PubMed
  35. 35.↵
    1. Desikan RS,
    2. Segonne F,
    3. Fischl B,
    4. et al
    . An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006;31: 968–80
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. McDonald CR,
    2. Hagler DJ Jr.,
    3. Ahmadi ME,
    4. et al
    . Regional neocortical thinning in mesial temporal lobe epilepsy. Epilepsia 2008;49: 794–803
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. Liu RS,
    2. Lemieux L,
    3. Sander JW,
    4. et al
    . Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy. Ann Neurol 2002;52: 861, author reply 862
  38. 38.↵
    1. Liu RS,
    2. Lemieux L,
    3. Bell GS,
    4. et al
    . Cerebral damage in epilepsy: a population-based longitudinal quantitative MRI study. Epilepsia 2005;46: 1482–94
    CrossRefPubMedWeb of Science
  39. 39.↵
    1. Pulsipher DT,
    2. Dabbs K,
    3. Tuchsherer V,
    4. et al
    . Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy. Neurology 2011;76: 28–33
    Abstract/FREE Full Text
  40. 40.↵
    1. Tosun D,
    2. Dabbs K,
    3. Caplan R,
    4. et al
    . Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy. Brain 2011;134 (Pt 4): 1003–14. Epub 2011 Mar 11
    Abstract/FREE Full Text
  41. 41.↵
    1. Janssen J,
    2. Reig S,
    3. Aleman Y,
    4. et al
    . Gyral and sulcal cortical thinning in adolescents with first episode early-onset psychosis. Biol Psychiatry 2009;66: 1047–54
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 33 (4)
American Journal of Neuroradiology
Vol. 33, Issue 4
1 Apr 2012
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Reduced Cortical Thickness in Children with New-Onset Seizures
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
E. Widjaja, S. Zarei Mahmoodabadi, C. Go, C. Raybaud, S. Chuang, O.C. Snead, M.L. Smith
Reduced Cortical Thickness in Children with New-Onset Seizures
American Journal of Neuroradiology Apr 2012, 33 (4) 673-677; DOI: 10.3174/ajnr.A2982

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Reduced Cortical Thickness in Children with New-Onset Seizures
E. Widjaja, S. Zarei Mahmoodabadi, C. Go, C. Raybaud, S. Chuang, O.C. Snead, M.L. Smith
American Journal of Neuroradiology Apr 2012, 33 (4) 673-677; DOI: 10.3174/ajnr.A2982
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Widespread, depth-dependent cortical microstructure alterations in paediatric focal epilepsy
  • Crossref (15)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Preliminary evidence of cognitive and brain abnormalities in uncomplicated adolescent obesity
    Po Lai Yau, Esther H. Kang, David C. Javier, Antonio Convit
    Obesity 2014 22 8
  • The relevance of neuropsychiatric symptoms and cognitive problems in new-onset epilepsy — Current knowledge and understanding
    B. Pohlmann-Eden, A. Aldenkamp, G.A. Baker, C. Brandt, F. Cendes, R. Coras, C.E. Crocker, C. Helmstaedter, M. Jones-Gotman, A.M. Kanner, A. Mazarati, M. Mula, M.L. Smith, A. Omisade, J. Tellez-Zenteno, B.P. Hermann
    Epilepsy & Behavior 2015 51
  • Neurodevelopmental alterations of large‐scale structural networks in children with new‐onset epilepsy
    Leonardo Bonilha, Ali Tabesh, Kevin Dabbs, David A. Hsu, Carl E. Stafstrom, Bruce P. Hermann, Jack J. Lin
    Human Brain Mapping 2014 35 8
  • Abnormal white matter on diffusion tensor imaging in children with new-onset seizures
    E. Widjaja, A. Kis, C. Go, C. Raybaud, O.C. Snead, M.L. Smith
    Epilepsy Research 2013 104 1-2
  • Multivariate white matter alterations are associated with epilepsy duration
    Thomas W. Owen, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S Duncan, Yujiang Wang, Peter N. Taylor
    European Journal of Neuroscience 2021 53 8
  • Cortical thickness asymmetries and surgical outcome in neocortical epilepsy
    David O. Kamson, Vinod K. Pilli, Eishi Asano, Jeong-Won Jeong, Sandeep Sood, Csaba Juhász, Harry T. Chugani
    Journal of the Neurological Sciences 2016 368
  • Cortical thickness in childhood left focal epilepsy: Thinning beyond the seizure focus
    Emanuel M. Boutzoukas, Jason Crutcher, Eduardo Somoza, Leigh N. Sepeta, Xiaozhen You, William D. Gaillard, Gregory L. Wallace, Madison M. Berl
    Epilepsy & Behavior 2020 102
  • Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development
    Vinod K. Pilli, Jeong‐Won Jeong, Praneetha Konka, Ajay Kumar, Harry T. Chugani, Csaba Juhász
    Human Brain Mapping 2019 40 1
  • Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy
    Feride Kural Rahatli, Taner Sezer, Arzu Ceylan Has, Ahmet Muhtesem Agildere
    Neurological Sciences 2020 41 4
  • Imaging and genetics of language and cognition in pediatric epilepsy
    Laura Addis, Jack J. Lin, Deb K. Pal, Bruce Hermann, Rochelle Caplan
    Epilepsy & Behavior 2013 26 3

More in this TOC Section

  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • ASL in PEDS Nontraumatic Orbital Lesions
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire