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Research ArticlePediatrics

No Evidence for Impairment of Venous Hemodynamics in Children or Young Adults with Pediatric-Onset Multiple Sclerosis

S. Laughlin, C.K. Macgowan, J. Traubici, K. Chan, S. Khan, D.L. Arnold, R.A. Marrie and B. Banwell
American Journal of Neuroradiology December 2013, 34 (12) 2366-2372; DOI: https://doi.org/10.3174/ajnr.A3661
S. Laughlin
aFrom the Departments of Diagnostic Imaging (S.L., J.T.)
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C.K. Macgowan
bMedical Biophysics (C.K.M., K.C.)
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J. Traubici
aFrom the Departments of Diagnostic Imaging (S.L., J.T.)
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K. Chan
bMedical Biophysics (C.K.M., K.C.)
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S. Khan
cNeuroscience and Mental Health (S.K., B.B.), The Hospital for Sick Children and Research Institute, University of Toronto, Ontario, Canada
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D.L. Arnold
dMcConnell Brain Imaging Center (D.L.A.), McGill University, Montreal, Quebec, Canada
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R.A. Marrie
eDepartments of Internal Medicine (Neurology) and Community Health Sciences (R.A.M.), University of Manitoba, Winnipeg, Manitoba, Canada
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B. Banwell
cNeuroscience and Mental Health (S.K., B.B.), The Hospital for Sick Children and Research Institute, University of Toronto, Ontario, Canada
fDepartment of Neurology (B.B.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
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REFERENCES

  1. 1.↵
    1. Awad AM,
    2. Marder E,
    3. Milo R,
    4. et al
    . Multiple sclerosis and chronic cerebrospinal venous insufficiency: a critical review. Ther Adv Neurol Disord 2011;4:231–35
    Abstract/FREE Full Text
  2. 2.↵
    1. Laupacis A,
    2. Lillie E,
    3. Dueck A,
    4. et al
    . Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis. CMAJ 2011;183:E1203–12
    Abstract/FREE Full Text
  3. 3.↵
    1. Zamboni P,
    2. Galeotti R,
    3. Menegatti E,
    4. et al
    . Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009;80:392–99
    Abstract/FREE Full Text
  4. 4.↵
    1. Zamboni P,
    2. Menegatti E,
    3. Galeotti R,
    4. et al
    . The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci 2009;282:21–27
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Weinstock-Guttman B,
    2. Ramanathan M,
    3. Marr K,
    4. et al
    . Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis. BMC Neurol 2012;12:26
    CrossRefPubMed
  6. 6.↵
    1. Patti F,
    2. Nicoletti A,
    3. Leone C,
    4. et al
    . Multiple sclerosis and CCSVI: a population-based case control study. PLoS One 2012;7:e41227
    CrossRefPubMed
  7. 7.↵
    1. Banwell B,
    2. Krupp L,
    3. Kennedy J,
    4. et al
    . Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study. Lancet Neurol 2007;6:773–81
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Gorman M,
    2. Healy B,
    3. Polgar-Turcsanyi M,
    4. et al
    . Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Arch Neurol 2009;66:54–59
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Mikaeloff Y,
    2. Caridade G,
    3. Husson B,
    4. et al
    . Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol 2007;11:90–95
    PubMedWeb of Science
  10. 10.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B,
    4. et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Sadaka Y,
    2. Verhey LH,
    3. Shroff MM,
    4. et al
    . 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Ann Neurol 2012;72:211–23
    CrossRefPubMed
  12. 12.↵
    1. Chabas D,
    2. Castillo-Trivino T,
    3. Mowry EM,
    4. et al
    . Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology 2008;71:1090–93
    CrossRef
  13. 13.↵
    1. Doepp F,
    2. Wurfel JT,
    3. Pfueller CF,
    4. et al
    . Venous drainage in multiple sclerosis: a combined MRI and ultrasound study. Neurology 2011;77:1745–51
    CrossRef
  14. 14.↵
    1. Polman CH,
    2. Reingold SC,
    3. Edan G,
    4. et al
    . Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria.” Ann Neurol 2005;58:840–46
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Heiberg E,
    2. Sjogren J,
    3. Ugander M,
    4. et al
    . Design and validation of Segment–freely available software for cardiovascular image analysis. BMC Med Imaging 2010;10:1
    CrossRefPubMed
  16. 16.↵
    1. Walker PG,
    2. Cranney GB,
    3. Scheidegger MB,
    4. et al
    . Semiautomated method for noise reduction and background phase error correction in MR phase velocity data. J Magn Reson Imaging 1993;3:521–30
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Stoquart-Elsankari S,
    2. Lehmann P,
    3. Villette A,
    4. et al
    . A phase-contrast MRI study of physiologic cerebral venous flow. J Cereb Blood Flow Metab 2009;29:1208–15
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Haacke EM,
    2. Feng W,
    3. Utriainen D,
    4. et al
    . Patients with multiple sclerosis with structural venous abnormalities on MR imaging exhibit an abnormal flow distribution of the internal jugular veins. J Vasc Interv Radiol 2012;23:60–68.e1–3
    CrossRefPubMed
  19. 19.↵
    1. Doepp F,
    2. Paul F,
    3. Valdueza JM,
    4. et al
    . No cerebrocervical venous congestion in patients with multiple sclerosis. Ann Neurol 2010;68:173–83
    PubMedWeb of Science
  20. 20.↵
    1. Auriel E,
    2. Karni A,
    3. Bornstein NM,
    4. et al
    . Extra-cranial venous flow in patients with multiple sclerosis. J Neurol Sci 2011;309:102–04
    CrossRefPubMed
  21. 21.↵
    1. Baracchini C,
    2. Valdueza JM,
    3. Del Sette M,
    4. et al
    . CCSVI and MS: a statement from the European Society of Neurosonology and Cerebral Hemodynamics. J Neurol 2012;259:2585–89
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Sundström P,
    2. Wahlin A,
    3. Ambarki K,
    4. et al
    . Venous and cerebrospinal fluid flow in multiple sclerosis: a case-control study. Ann Neurol 2010;68:255–59
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Mayer CA,
    2. Pfeilschifter W,
    3. Lorenz MW,
    4. et al
    . The perfect crime? CCSVI not leaving a trace in MS. J Neurol Neurosurg Psychiatry 2011;82:436–40
    Abstract/FREE Full Text
  24. 24.↵
    1. Zivadinov R,
    2. Marr K,
    3. Cutter G,
    4. et al
    . Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology 2011;77:138–44
    CrossRef
  25. 25.↵
    1. Amato M,
    2. Saia V,
    3. Hakiki B,
    4. et al
    . No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis. Mult Scler 2012;18:1791–96
    Abstract/FREE Full Text
  26. 26.↵
    1. Singh AV,
    2. Zamboni P
    . Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 2009;29:1867–78
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Baracchini C,
    2. Perini P,
    3. Calabrese M,
    4. et al
    . No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol 2011;69:90–99
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Blinkenberg M,
    2. Akeson P,
    3. Sillesen H,
    4. et al
    . Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis. Acta Neurol Scand 2012;126:421–27
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Yamout B,
    2. Herlopian A,
    3. Issa Z,
    4. et al
    . Extracranial venous stenosis is an unlikely cause of multiple sclerosis. Mult Scler 2010;16:1341–48
    Abstract/FREE Full Text
  30. 30.↵
    1. Dolic K,
    2. Weinstock-Guttman B,
    3. Marr K,
    4. et al
    . Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers. PLoS One 2011;6:e28062
    CrossRefPubMed
  31. 31.↵
    1. Atkinson W,
    2. Forghani R,
    3. Wojtkiewicz GR,
    4. et al
    . Ligation of the jugular veins does not result in brain inflammation or demyelination in mice. PLoS One 2012;7:e33671
    CrossRefPubMed
  32. 32.
    1. Zamboni P,
    2. Galeotti R,
    3. Menegatti E,
    4. et al
    . A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vasc Surg 2009;50:1348–58.e1
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 34 (12)
American Journal of Neuroradiology
Vol. 34, Issue 12
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Cite this article
S. Laughlin, C.K. Macgowan, J. Traubici, K. Chan, S. Khan, D.L. Arnold, R.A. Marrie, B. Banwell
No Evidence for Impairment of Venous Hemodynamics in Children or Young Adults with Pediatric-Onset Multiple Sclerosis
American Journal of Neuroradiology Dec 2013, 34 (12) 2366-2372; DOI: 10.3174/ajnr.A3661

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No Evidence for Impairment of Venous Hemodynamics in Children or Young Adults with Pediatric-Onset Multiple Sclerosis
S. Laughlin, C.K. Macgowan, J. Traubici, K. Chan, S. Khan, D.L. Arnold, R.A. Marrie, B. Banwell
American Journal of Neuroradiology Dec 2013, 34 (12) 2366-2372; DOI: 10.3174/ajnr.A3661
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  • MR Elastography Can Be Used to Measure Brain Stiffness Changes as a Result of Altered Cranial Venous Drainage During Jugular Compression
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    American Journal of Neuroradiology 2015 36 10
  • Cerebral arterial and venous blood flow in adolescent multiple sclerosis patients and age‐matched controls using phase contrast MRI
    Christopher K. Macgowan, Katherine Y. Chan, Suzanne Laughlin, Ruth Ann Marrie, Brenda Banwell
    Journal of Magnetic Resonance Imaging 2014 40 2
  • Quantified hemodynamic parameters of the venous system in multiple sclerosis: A systematic review
    Alexander Robert Bateman, Jeannette Lechner-Scott, Tracie Barber, Grant Alexander Bateman, Saadallah Ramadan
    Multiple Sclerosis and Related Disorders 2022 57

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