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Research ArticlePediatrics

Abnormal Functional Network Connectivity among Resting-State Networks in Children with Frontal Lobe Epilepsy

E. Widjaja, M. Zamyadi, C. Raybaud, O.C. Snead and M.L. Smith
American Journal of Neuroradiology December 2013, 34 (12) 2386-2392; DOI: https://doi.org/10.3174/ajnr.A3608
E. Widjaja
aFrom Diagnostic Imaging (E.W., M.Z., C.R., O.C.S.)
bDivision of Neurology, Hospital for Sick Children (E.W.), Toronto, Ontario, Canada
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M. Zamyadi
aFrom Diagnostic Imaging (E.W., M.Z., C.R., O.C.S.)
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C. Raybaud
aFrom Diagnostic Imaging (E.W., M.Z., C.R., O.C.S.)
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O.C. Snead
aFrom Diagnostic Imaging (E.W., M.Z., C.R., O.C.S.)
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M.L. Smith
cDepartment of Psychology (M.L.S.), University of Toronto, Toronto, Ontario, Canada.
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    Fig 1.

    Spatial maps of the components identified as resting-state networks. Spatial maps are plotted as T-maps and overlaid on Montreal Neurological Institute 152 template. Top row (from left to right) shows the auditory, frontal, and default mode networks. Second, third, and fourth rows represent the visual, sensorimotor, and attention networks.

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    Fig 2.

    Regions showing group differences in spatial maps for the sensorimotor, attention, and default mode networks, and frontal, auditory, and visual networks.

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    Fig 3.

    Functional network connectivity between resting-state networks. Group comparison of pair-wise independent components shows reduced FNC (solid line) between DMN-attention (IC4-IC65), frontal-sensorimotor (IC46-IC12), and frontal-visual (IC46-IC52) networks in patients and increased FNC (dotted line) between frontal-attention (IC40-IC65), DMN-sensorimotor (IC50-IC60), and frontal-visual (IC40-IC63) networks in patients relative to control subjects.

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American Journal of Neuroradiology: 34 (12)
American Journal of Neuroradiology
Vol. 34, Issue 12
1 Dec 2013
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Cite this article
E. Widjaja, M. Zamyadi, C. Raybaud, O.C. Snead, M.L. Smith
Abnormal Functional Network Connectivity among Resting-State Networks in Children with Frontal Lobe Epilepsy
American Journal of Neuroradiology Dec 2013, 34 (12) 2386-2392; DOI: 10.3174/ajnr.A3608

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Abnormal Functional Network Connectivity among Resting-State Networks in Children with Frontal Lobe Epilepsy
E. Widjaja, M. Zamyadi, C. Raybaud, O.C. Snead, M.L. Smith
American Journal of Neuroradiology Dec 2013, 34 (12) 2386-2392; DOI: 10.3174/ajnr.A3608
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