A Novel Technique for the Measurement of CBF and CBV with Robot-Arm-Mounted Flat Panel CT in a Large-Animal Model

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig 1.
Intracranial vessels before (A) and after (B) vessel occlusion (black arrow). Contrast material was injected near the rete mirabile (white arrow in A). The MCA surfaces shortly after branching off the ICA (black asterisk in A), which also gives rise to the posterior cerebral artery. Due to early branching, the complete MCA territory was not affected.
Download figure
Open in new tab
Download powerpoint
Fig 2.
Color maps of CBF and CBV for all protocols 3 hours after vessel occlusion on the left side. Perfusion deficits are clearly visible, but image quality is impaired by streak artifacts, especially in the fast scan. The prototype is CTP data processed with the prototype software. VPCT is CTP data processed with commercial software.
Download figure
Open in new tab
Download powerpoint
Fig 3.
Manually chosen arterial input function in the ICA near the skull base and corresponding time-attenuation curve.

Table 1:

Overview over the acquisition of datasets

	C-Arm 3 Seconds	C-Arm 5 Seconds	CTP Prototype^{^a}	CTP VPCT^{^b}
Sheep 1
Pre	v	v	v	v
0 Hours	v	v	v	v
3 Hours	v	v	v	v
Sheep 2
Pre	v	v	v	v
0 Hours	v	v	v	v
3 Hours	v	v	v	v
Sheep 3
Pre	v	v	v	x
0 Hours	x	x	v	v
3 Hours	v	v	v	v
Sheep 4
Pre	x	v	v	v
0 Hours	x	x	x	x
3 Hours	x	x	x	x
Sheep 5	x	x	x	x
	x	x	x	x
	x	x	x	x
Sheep 6
Pre	v	v	v	v
0 Hours	v	v	v	v
3 Hours	v	v	v	v
Sheep 7
Pre	v	v	v	v
0 Hours	v	v	v	v
3 Hours	v	v	v	v
Total	14	15	16	15

Note:—Pre indicates data acquired before surgery; v, sets that were acquired as the protocol demanded and that were included in the evaluation; x, excluded datasets (The reasons are explained in the text) .
↵a Datasets acquired with CTP and calculated with the prototype software.
↵b Datasets acquired with CTP and calculated with the commercial software VPCT (Siemens).

Table 2:

Sensitivity and specificity for lesion detection shown separately for each reader and protocol