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Research ArticleFunctional

Crossed Cerebrocerebellar Language Lateralization: An Additional Diagnostic Feature for Assessing Atypical Language Representation in Presurgical Functional MR Imaging

C. Méndez Orellana, E. Visch-Brink, M. Vernooij, S. Kalloe, D. Satoer, A. Vincent, A. van der Lugt and M. Smits
American Journal of Neuroradiology March 2015, 36 (3) 518-524; DOI: https://doi.org/10.3174/ajnr.A4147
C. Méndez Orellana
aFrom the Departments of Radiology (C.M.O., M.V., S.K., A.v.d.L., M.S.)
bNeurology (C.M.O., E.V.-B)
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E. Visch-Brink
bNeurology (C.M.O., E.V.-B)
cNeurosurgery (E.V.-B., D.S., A.V.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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M. Vernooij
aFrom the Departments of Radiology (C.M.O., M.V., S.K., A.v.d.L., M.S.)
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S. Kalloe
aFrom the Departments of Radiology (C.M.O., M.V., S.K., A.v.d.L., M.S.)
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D. Satoer
cNeurosurgery (E.V.-B., D.S., A.V.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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A. Vincent
cNeurosurgery (E.V.-B., D.S., A.V.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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A. van der Lugt
aFrom the Departments of Radiology (C.M.O., M.V., S.K., A.v.d.L., M.S.)
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M. Smits
aFrom the Departments of Radiology (C.M.O., M.V., S.K., A.v.d.L., M.S.)
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  • Fig 1.
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    Fig 1.

    Cerebrocerebellar language representation in healthy participants and patients. The 4 patients with no activation in the cerebellum (as described in On-line Table 2) are not represented in this figure. Sym. indicates symmetric.

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    Fig 2.

    Scatterplot of the healthy participant lateralization indices of the cerebrum and cerebellum.

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    Fig 3.

    A, Language activation of a left-handed, bilingual patient, with tumor in the left middle frontal gyrus (blue arrowhead), showing symmetric cerebral activation and right-lateralized cerebellar activation. B, Language activation of a right-handed patient with tumor in the right middle temporal and angular gyri (blue arrowhead), showing atypical, right-lateralized cerebral activation and crossed cerebellar lateralization.

Tables

  • Figures
  • Healthy participant demographics and lateralization indices

    Age (yr)SexEHI ScoreaLI CerebrumLI CerebellumLateralization CerebrumLateralization Cerebellum
    25M−1000.42−0.36LR
    30M−100−0.440.34RL
    33F−100−0.270.03RS
    27F−1000.34−0.41LR
    28F−1000.02−0.43SR
    35F−1000.24−0.19LR
    53M−90−0.180.13RL
    36F−90−0.280.07RS
    30M−800.13−0.22LR
    29M−780.32−0.40LR
    28F−20−0.04−0.13SR
    31M−200.480.00LS
    43M0−0.180.00RS
    30F1000.21−0.30LR
    34F1000.16−0.04LS
    34M1000.32−0.12LR
    34F1000.31−0.46LR
    29F1000.42−0.30LR
    32M1000.33−0.09LS
    28F1000.43−0.25LR
    • Note:—L indicates left-sided; R, right-sided; S, symmetric; EHI, Oldfield Edinburgh Handedness Inventory.

    • ↵a Handedness was assessed with the Oldfield Edinburgh Handedness Inventory.

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American Journal of Neuroradiology: 36 (3)
American Journal of Neuroradiology
Vol. 36, Issue 3
1 Mar 2015
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Cite this article
C. Méndez Orellana, E. Visch-Brink, M. Vernooij, S. Kalloe, D. Satoer, A. Vincent, A. van der Lugt, M. Smits
Crossed Cerebrocerebellar Language Lateralization: An Additional Diagnostic Feature for Assessing Atypical Language Representation in Presurgical Functional MR Imaging
American Journal of Neuroradiology Mar 2015, 36 (3) 518-524; DOI: 10.3174/ajnr.A4147

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Crossed Cerebrocerebellar Language Lateralization: An Additional Diagnostic Feature for Assessing Atypical Language Representation in Presurgical Functional MR Imaging
C. Méndez Orellana, E. Visch-Brink, M. Vernooij, S. Kalloe, D. Satoer, A. Vincent, A. van der Lugt, M. Smits
American Journal of Neuroradiology Mar 2015, 36 (3) 518-524; DOI: 10.3174/ajnr.A4147
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