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Research ArticleAdult Brain
Open Access

White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging

A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori and S. Aoki
American Journal of Neuroradiology October 2019, 40 (10) 1642-1648; DOI: https://doi.org/10.3174/ajnr.A6209
A. Hagiwara
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • ORCID record for A. Hagiwara
K. Kamagata
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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  • ORCID record for K. Kamagata
K. Shimoji
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
dDepartment of Diagnostic Radiology (K.S.), Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
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K. Yokoyama
bNeurology (K.Y., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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  • ORCID record for K. Yokoyama
C. Andica
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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M. Hori
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
eDepartment of Radiology (M.H.), Toho University Omori Medical Center, Tokyo, Japan.
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  • ORCID record for M. Hori
S. Fujita
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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T. Maekawa
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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R. Irie
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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T. Akashi
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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A. Wada
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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M. Suzuki
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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O. Abe
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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N. Hattori
bNeurology (K.Y., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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S. Aoki
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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    Fig 1.

    TBSS results are shown for FA, ISO, and MVF maps, which show significant differences between patients with MS and healthy controls. Green represents the mean FA skeleton of all participants thresholded at 0.2. Blue–light blue represents lower values in patients with MS compared with healthy controls in FA (first row) and MVF (third row) maps; red-yellow represents higher values in ISO maps (second row) (family-wise error-corrected P < .05). The significant regions are thickened for better visibility. The mean lesion probability distribution in patients with MS, thresholded at 20%, is shown in the fourth row in purple.

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    Fig 2.

    Quantitative metrics compared among the WM of healthy controls, NAWM of patients with MS, and WM lesions of patients with MS. The median and 25th and 75th percentiles are marked in boxplots, with outliers plotted by open circles. Asterisks indicate significant differences among the groups. The asterisk indicates P < .05; double asterisks, P < .01; triple asterisks, P < .001.

Tables

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  • Demographic and clinical details of all participants

    MSHealthy ControlP Values
    No. of subjects2424
    Mean age (yr)39.83 ± 8.2539.50 ± 11.13.91a
    Sex (male/female)5:195:191b
    Disease duration (mean) (yr)11.82 ± 5.99NA
    EDSS score (range)1 (0–7)NA
    White matter lesion volume (mean) (mL)10.05 ± 10.00NA
    • Note:—NA indicates not applicable.

    • ↵a Two-sample t test.

    • ↵b χ2 test.

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American Journal of Neuroradiology: 40 (10)
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Cite this article
A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori, S. Aoki
White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging
American Journal of Neuroradiology Oct 2019, 40 (10) 1642-1648; DOI: 10.3174/ajnr.A6209

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White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging
A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori, S. Aoki
American Journal of Neuroradiology Oct 2019, 40 (10) 1642-1648; DOI: 10.3174/ajnr.A6209
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