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Research ArticleAdult Brain
Open Access

White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging

A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori and S. Aoki
American Journal of Neuroradiology October 2019, 40 (10) 1642-1648; DOI: https://doi.org/10.3174/ajnr.A6209
A. Hagiwara
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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  • ORCID record for A. Hagiwara
K. Kamagata
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
  • Find this author on Google Scholar
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  • ORCID record for K. Kamagata
K. Shimoji
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
dDepartment of Diagnostic Radiology (K.S.), Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
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  • ORCID record for K. Shimoji
K. Yokoyama
bNeurology (K.Y., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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  • ORCID record for K. Yokoyama
C. Andica
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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  • ORCID record for C. Andica
M. Hori
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
eDepartment of Radiology (M.H.), Toho University Omori Medical Center, Tokyo, Japan.
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  • ORCID record for M. Hori
S. Fujita
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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T. Maekawa
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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R. Irie
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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T. Akashi
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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A. Wada
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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M. Suzuki
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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O. Abe
cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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N. Hattori
bNeurology (K.Y., N.H.), Juntendo University School of Medicine, Tokyo, Japan
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S. Aoki
aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
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Article Information

vol. 40 no. 10 1642-1648
DOI 
https://doi.org/10.3174/ajnr.A6209
PubMed 
31515218

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received June 6, 2019
  • Accepted after revision July 28, 2019
  • Published online October 8, 2019.

Copyright & Usage 
© 2019 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. A. Hagiwaraa,c,
  2. K. Kamagataa,
  3. K. Shimojia,d,
  4. K. Yokoyamab,
  5. C. Andicaa,
  6. M. Horia,e,
  7. S. Fujitaa,c,
  8. T. Maekawaa,c,
  9. R. Iriea,c,
  10. T. Akashia,
  11. A. Wadaa,
  12. M. Suzukia,
  13. O. Abec,
  14. N. Hattorib and
  15. S. Aokia
  1. aFrom the Departments of Radiology (A.H., K.K., K.S., C.A., M.H., S.F., T.M., R.I., T.A., A.W., M.S., S.A.)
  2. bNeurology (K.Y., N.H.), Juntendo University School of Medicine, Tokyo, Japan
  3. cDepartment of Radiology (A.H., S.F., T.M., R.I., O.A.), Graduate School of Medicine, University of Tokyo, Tokyo, Japan
  4. dDepartment of Diagnostic Radiology (K.S.), Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
  5. eDepartment of Radiology (M.H.), Toho University Omori Medical Center, Tokyo, Japan.
  1. Please address correspondence to Akifumi Hagiwara, MD, PhD, Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hungo, Bunkyo-ku, Tokyo, Japan 113-8421; e-mail: a-hagiwara{at}juntendo.ac.jp
View Full Text

Funding

  • Grant-in-Aid for Scientific Research on Innovative Areas - Resource and technical support platforms for promoting research “Advanced Bioimaging Support”

    JP16H06280
  • program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development, AMED

    N/A
  • Japan Society for the Promotion of Science

    18H02772; 18K15643; 19K17150; 19K17177
  • Japanese Society for Magnetic Resonance in Medicine

Altmetrics

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    Magnetic Resonance in Medical Sciences 2022 21 1
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A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori, S. Aoki
White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging
American Journal of Neuroradiology Oct 2019, 40 (10) 1642-1648; DOI: 10.3174/ajnr.A6209

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White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging
A. Hagiwara, K. Kamagata, K. Shimoji, K. Yokoyama, C. Andica, M. Hori, S. Fujita, T. Maekawa, R. Irie, T. Akashi, A. Wada, M. Suzuki, O. Abe, N. Hattori, S. Aoki
American Journal of Neuroradiology Oct 2019, 40 (10) 1642-1648; DOI: 10.3174/ajnr.A6209
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  • Myelin and Axonal Damage in Normal-Appearing White Matter in Patients with Moyamoya Disease
  • Crossref (12)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Advanced Diffusion MR Imaging for Multiple Sclerosis in the Brain and Spinal Cord
    Masaaki Hori, Tomoko Maekawa, Kouhei Kamiya, Akifumi Hagiwara, Masami Goto, Mariko Yoshida Takemura, Shohei Fujita, Christina Andica, Koji Kamagata, Julien Cohen-Adad, Shigeki Aoki
    Magnetic Resonance in Medical Sciences 2022 21 1
  • Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis
    Shuchang Zhong, Jingjing Lou, Ke Ma, Zhenyu Shu, Lin Chen, Chao Li, Qing Ye, Liang Zhou, Ye Shen, Xiangming Ye, Jie Zhang
    Brain Imaging and Behavior 2023 17 6
  • Myelin and Axonal Damage in Normal-Appearing White Matter in Patients with Moyamoya Disease
    S. Hara, M. Hori, A. Hagiwara, Y. Tsurushima, Y. Tanaka, T. Maehara, S. Aoki, T. Nariai
    American Journal of Neuroradiology 2020
  • Short-Range Structural Connections Are More Severely Damaged in Early-Stage MS
    H. Wu, C. Sun, X. Huang, R. Wei, Z. Li, D. Ke, R. Bai, H. Liang
    American Journal of Neuroradiology 2022 43 3
  • Altered regional brain white matter in dry eye patients: a brain imaging study
    Yun-Qing Luo, Rong-Bin Liang, San-Hua Xu, Yi-Cong Pan, Qiu-Yu Li, Hui-Ye Shu, Min Kang, Pin Yin, Li-Juan Zhang, Yi Shao
    Aging 2022 14 6
  • Non-contrast magnetic resonance evaluation of active multiple sclerosis lesions: Emerging role of quantitative synthetic magnetic resonance imaging
    Sachin Girdhar, Sruthi S Nair, Bejoy Thomas, Chandrasekharan Kesavadas
    The Neuroradiology Journal 2025 38 2
  • The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study
    Chunxiang Zhang, Xin Zhao, Meiying Cheng, Kaiyu Wang, Xiaoan Zhang
    Frontiers in Neurology 2021 12
  • Longitudinal Identification of Pre‐Lesional Tissue in Multiple Sclerosis With Advanced Diffusion MRI
    Maria Caranova, Júlia F. Soares, Daniela Jardim Pereira, Ana Cláudia Lima, Lívia Sousa, Sónia Batista, Miguel Castelo‐Branco, João V. Duarte
    Journal of Neuroimaging 2025 35 1
  • Reduced White Matter Fiber Density in Patients with Multiple Sclerosis
    Zeinab Gharaylou, Fatemeh Shahbodaghy, Pirhossein Kolivand, Maryam Kolivand, Fatemeh Azizzadeh, Masoumeh Rostampour
    Brain Connectivity 2024 14 3
  • Technical aspects and clinical applications of synthetic MRI: a scoping review
    Tancia Pires, Saikiran Pendem, Jaseemudheen M.M., Priyanka
    Diagnosis 2025 12 2

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