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Research ArticleAdult Brain
Open Access

Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma

M.D. Lee, G.L. Baird, L.C. Bell, C.C. Quarles and J.L. Boxerman
American Journal of Neuroradiology September 2019, 40 (9) 1445-1450; DOI: https://doi.org/10.3174/ajnr.A6153
M.D. Lee
aFrom the Warren Alpert Medical School of Brown University (M.D.L., J.L.B.), Providence, Rhode Island
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G.L. Baird
bDepartment of Diagnostic Imaging (G.L.B., J.L.B.), Rhode Island Hospital, Providence, Rhode Island
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L.C. Bell
cDivision of Neuroimaging Research (L.C.B., C.C.Q.), Barrow Neurological Institute, Phoenix, Arizona.
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C.C. Quarles
cDivision of Neuroimaging Research (L.C.B., C.C.Q.), Barrow Neurological Institute, Phoenix, Arizona.
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J.L. Boxerman
aFrom the Warren Alpert Medical School of Brown University (M.D.L., J.L.B.), Providence, Rhode Island
bDepartment of Diagnostic Imaging (G.L.B., J.L.B.), Rhode Island Hospital, Providence, Rhode Island
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    Fig 1.

    Comparisons of rCBV (A), PSR (B), and normalized baseline SI (C) estimates with 95% confidence intervals for glioblastoma, PCNSL, metastasis (Met), and meningioma (Mening).

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    Fig 2.

    Average normalized signal-time curves for glioblastoma multiforme (solid black), PCNSL (solid gray), metastasis (dotted black), and meningioma (dotted gray). TR = 1290 ms, with a total acquisition time of 2 minutes 35 seconds.

Tables

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  • Pair-wise discrimination performance (Somers D) of perfusion parameters and baseline SI

    Pair-wise ComparisonrCBVPSRBaseline SI
    GBM vs PCNSL0.79 (0.58–0.99)0.83 (0.64–1.00)0.50 (0.23–0.77)
    D = 0.57D = 0.65D = 0.00
    GBM vs metastasis0.43 (0.24–0.63)0.49 (0.28–0.69)0.66 (0.47–0.84)
    D =−0.14D = −0.03D = 0.31
    GBM vs meningioma0.84 (0.69–0.99)0.69 (0.47–0.91)0.76 (0.56–0.95)
    D = 0.68D = 0.37D = 0.52
    PCNSL vs metastasis0.66 (0.43–0.88)0.81 (0.64–0.97)0.66 (0.43–0.88)
    D = 0.31D = 0.61D = 0.31
    PCNSL vs meningioma0.97 (0.90–1.00)0.89 (0.74–1.00)0.71 (0.46–0.97)
    D = 0.93D = 0.78D = 0.43
    Metastasis vs meningioma0.82 (0.68–0.96)0.65 (0.44–0.87)0.55 (0.35–0.75)
    D = 0.64D = 0.31D = 0.10
    • Note:—GBM indicates glioblastoma multiforme; D, Somers D.

    • a Data are area AUC and 95% CI).

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American Journal of Neuroradiology: 40 (9)
American Journal of Neuroradiology
Vol. 40, Issue 9
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M.D. Lee, G.L. Baird, L.C. Bell, C.C. Quarles, J.L. Boxerman
Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma
American Journal of Neuroradiology Sep 2019, 40 (9) 1445-1450; DOI: 10.3174/ajnr.A6153

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Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma
M.D. Lee, G.L. Baird, L.C. Bell, C.C. Quarles, J.L. Boxerman
American Journal of Neuroradiology Sep 2019, 40 (9) 1445-1450; DOI: 10.3174/ajnr.A6153
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