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Research ArticleAdult Brain
Open Access

A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images

L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin and for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology April 2021, 42 (4) 639-647; DOI: https://doi.org/10.3174/ajnr.A6970
L. Umapathy
aFrom the Departments of Electrical and Computer Engineering (L.U., A.B.)
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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G.G. Perez-Carrillo
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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M.B. Keerthivasan
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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J.A. Rosado-Toro
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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M.I. Altbach
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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B. Winegar
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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C. Weinkauf
cSurgery (C.W.)
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A. Bilgin
aFrom the Departments of Electrical and Computer Engineering (L.U., A.B.)
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
dBiomedical Engineering (A.B.), University of Arizona, Tucson, Arizona
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Article Information

vol. 42 no. 4 639-647
DOI 
https://doi.org/10.3174/ajnr.A6970
PubMed 
33574101

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 13, 2020
  • Accepted after revision October 26, 2020
  • Published online April 12, 2021.

Copyright & Usage 
© 2021 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. L. Umapathya,b,
  2. G.G. Perez-Carrillob,
  3. M.B. Keerthivasanb,
  4. J.A. Rosado-Torob,
  5. M.I. Altbachb,
  6. B. Winegarb,
  7. C. Weinkaufc,
  8. A. Bilgina,b,d,
  9. for the Alzheimer’s Disease Neuroimaging Initiative
  1. aFrom the Departments of Electrical and Computer Engineering (L.U., A.B.)
  2. bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
  3. cSurgery (C.W.)
  4. dBiomedical Engineering (A.B.), University of Arizona, Tucson, Arizona
  1. Please address correspondence to Ali Bilgin, PhD, Department of Biomedical Engineering, Thomas R. Keating Building, University of Arizona, 1657 E. Helen Street, Tucson, AZ, 85721; e-mail: bilgin{at}email.arizona.edu
View Full Text

Funding

  • Arizona Alzheimer's Consortium

  • Technology and Research Initiative Fund Improving Health Initiative

  • BIO5 Team Scholar's Program

  • Arizona Health Sciences Center Translational Imaging Program Project Stimulus Fund

Altmetrics

Cited By...

  • 4 Citations
  • 3 Citations
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Convolutional Neural Network Based Frameworks for Fast Automatic Segmentation of Thalamic Nuclei from Native and Synthesized Contrast Structural MRI
    Lavanya Umapathy, Mahesh Bharath Keerthivasan, Natalie M. Zahr, Ali Bilgin, Manojkumar Saranathan
    Neuroinformatics 2022 20 3
  • Early detection of white matter hyperintensities usingSHIVA‐WMHdetector
    Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stéphanie Debette, Marc Joliot
    Human Brain Mapping 2024 45 1
  • Accelerated diffusion tensor imaging with self-supervision and fine-tuning
    Phillip Martin, Diego Martin, Maria Altbach, Ali Bilgin
    Scientific Reports 2025 15 1
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American Journal of Neuroradiology: 42 (4)
American Journal of Neuroradiology
Vol. 42, Issue 4
1 Apr 2021
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L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin, for the Alzheimer’s Disease Neuroimaging Initiative
A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images
American Journal of Neuroradiology Apr 2021, 42 (4) 639-647; DOI: 10.3174/ajnr.A6970

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A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images
L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin, for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology Apr 2021, 42 (4) 639-647; DOI: 10.3174/ajnr.A6970
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Cited By...

  • Early detection of white matter hyperintensities using SHIVA-WMH detector
  • Crossref (3)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Convolutional Neural Network Based Frameworks for Fast Automatic Segmentation of Thalamic Nuclei from Native and Synthesized Contrast Structural MRI
    Lavanya Umapathy, Mahesh Bharath Keerthivasan, Natalie M. Zahr, Ali Bilgin, Manojkumar Saranathan
    Neuroinformatics 2022 20 3
  • Early detection of white matter hyperintensities usingSHIVA‐WMHdetector
    Ami Tsuchida, Philippe Boutinaud, Violaine Verrecchia, Christophe Tzourio, Stéphanie Debette, Marc Joliot
    Human Brain Mapping 2024 45 1
  • Accelerated diffusion tensor imaging with self-supervision and fine-tuning
    Phillip Martin, Diego Martin, Maria Altbach, Ali Bilgin
    Scientific Reports 2025 15 1

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