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Research ArticleAdult Brain

Early Detection of Underlying Cavernomas in Patients with Spontaneous Acute Intracerebral Hematomas

A. Bani-Sadr, O.F. Eker, T.-H. Cho, R. Ameli, M. Berhouma, M. Cappucci, L. Derex, L. Mechtouff, D. Meyronet, N. Nighoghossian, Y. Berthezène and M. Hermier
American Journal of Neuroradiology July 2023, 44 (7) 807-813; DOI: https://doi.org/10.3174/ajnr.A7914
A. Bani-Sadr
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
eCreatis Laboratory (A.B.-S., O.F.E., Y.B.), National Center for Scientific Research Unité Mixte de Recherche 5220, Institut National de la Santé et de la Recherche Médicale U 5220, Claude Bernard Lyon I University, Villeurbanne, France
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  • ORCID record for A. Bani-Sadr
O.F. Eker
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
eCreatis Laboratory (A.B.-S., O.F.E., Y.B.), National Center for Scientific Research Unité Mixte de Recherche 5220, Institut National de la Santé et de la Recherche Médicale U 5220, Claude Bernard Lyon I University, Villeurbanne, France
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  • ORCID record for O.F. Eker
T.-H. Cho
bStroke Department (T.-H.C., L.D., L.M., N.N.)
fCarMeN Laboratory (T.-H.C., L.M., N.N.), Institut National de la Santé et de la Recherche Médicale U1060, Claude Bernard Lyon I University, Bron, France
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R. Ameli
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
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M. Berhouma
cSkull Base Surgery Unit (M.B.), Department of Neurosurgery B
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  • ORCID record for M. Berhouma
M. Cappucci
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
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L. Derex
bStroke Department (T.-H.C., L.D., L.M., N.N.)
gResearch on Healthcare Performance (L.D.), Institut National de la Santé et de la Recherche Médicale U 1290, Claude Bernard Lyon I University, Domaine Rockefeller, Lyon, France
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L. Mechtouff
bStroke Department (T.-H.C., L.D., L.M., N.N.)
fCarMeN Laboratory (T.-H.C., L.M., N.N.), Institut National de la Santé et de la Recherche Médicale U1060, Claude Bernard Lyon I University, Bron, France
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D. Meyronet
dInstitute of Pathology East, Neuropathology (D.M.), East Group Hospital, Hospices Civils de Lyon, Bron, France
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N. Nighoghossian
bStroke Department (T.-H.C., L.D., L.M., N.N.)
fCarMeN Laboratory (T.-H.C., L.M., N.N.), Institut National de la Santé et de la Recherche Médicale U1060, Claude Bernard Lyon I University, Bron, France
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Y. Berthezène
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
eCreatis Laboratory (A.B.-S., O.F.E., Y.B.), National Center for Scientific Research Unité Mixte de Recherche 5220, Institut National de la Santé et de la Recherche Médicale U 5220, Claude Bernard Lyon I University, Villeurbanne, France
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M. Hermier
aFrom the Department of Neuroradiology (A.B.-S., O.F.E., R.A., M.C., Y.B., M.H.)
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  • FIG 1.
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    FIG 1.

    Assessment of hematoma shape. A, Spherical, acute lobar hematoma on plain CT of a patient with a pathologically proved hemorrhagic cerebral cavernoma. B, Spherical lobar hematoma on T2*-weighted imaging in a patient with pathologically proved hemorrhagic cerebral cavernoma. C, Ovoid cerebellar hematoma on T2*-weighted imaging of a patient with pathologically proved hemorrhagic cavernoma. D, Plain CT obtained at admission in a patient with an angiographically proved cerebral AVM. The elongated shape of the hematoma did not fulfill the criteria spherical or ovoid. Its margins were considered irregular because angular aspects were present. It was associated with intraventricular hemorrhage. E and F, Hemorrhagic cerebral cavernoma. Both plain CT (D) and T2* MR images (E) were available to assess the hematoma shape. The hematoma shape was classified as spherical/ovoid on the basis of MR imaging.

  • FIG 2.
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    FIG 2.

    Assessment of hematoma margins. A and B, T1- and T2*-weighted MR imaging shows a hematoma with regular margins in a patient with pathologically proved hemorrhagic cavernoma in the setting of familial cavernomatosis. C and D, T1 and T2*-weighted MR imaging shows a hematoma in a patient with a pathologically proved cerebral cavernoma. The lesion was multiloculated with bumpy borders. The margins were classified as regular because no angular aspect was present in any part of the lesion. Hematoma with irregular margins presenting with angular aspects on plain CT (E) and T2*-weighted MR imaging (F) in 2 patients with arteriovenous shunts proved by cerebral angiography.

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    FIG 3.

    Flowchart of study population.

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    FIG 4.

    Decision tree model applied to the validation sample.

Tables

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  • Univariate and multivariate logistic regression for the diagnosis of hemorrhagic cavernomas

    Crude OR (95% CI)P ValueAdjusted OR (95% CI)P Value
    Spherical/ovoid36.60 (15.89–110.20)<.0016.11 (2.64–15.08)<.001
    Regular margins34.81 (14.99–103.90)<.0013.38 (1.44–8.61).009
    Extralesional hemorrhage0.06 (0.02–0.15)<.0010.39 (0.18–0.76).01
    Peripheral rim enhancement0.18 (0.03–0.53).0090.29 (0.13–0.59).002
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American Journal of Neuroradiology: 44 (7)
American Journal of Neuroradiology
Vol. 44, Issue 7
1 Jul 2023
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Cite this article
A. Bani-Sadr, O.F. Eker, T.-H. Cho, R. Ameli, M. Berhouma, M. Cappucci, L. Derex, L. Mechtouff, D. Meyronet, N. Nighoghossian, Y. Berthezène, M. Hermier
Early Detection of Underlying Cavernomas in Patients with Spontaneous Acute Intracerebral Hematomas
American Journal of Neuroradiology Jul 2023, 44 (7) 807-813; DOI: 10.3174/ajnr.A7914

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Early Detection of Cavernomas in Acute Hematomas
A. Bani-Sadr, O.F. Eker, T.-H. Cho, R. Ameli, M. Berhouma, M. Cappucci, L. Derex, L. Mechtouff, D. Meyronet, N. Nighoghossian, Y. Berthezène, M. Hermier
American Journal of Neuroradiology Jul 2023, 44 (7) 807-813; DOI: 10.3174/ajnr.A7914
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