Article Figures & Data
Figures
- FIG 1.
DSC voxel time-series in a representative healthy participant. The raw T2* signal time course in neighboring voxels adjacent to the MCA is shown in A and the CP in B. The green crosshairs in the T1 anatomical images show the corresponding locations of the center voxel in 3 planes for the MCA and CP AIF.
- FIG 2.
The scaled percentage signal changes across time after an injection of GBCA in the same healthy participant shown in Fig 1. A, The location of a voxel selected adjacent to the MCA, the superior sagittal sinus, and the CP. B, The scaled percentage signal change for each voxel as indicated in A.
- FIG 3.
Bland-Altman plots comparing GM perfusion metrics (MTT, rCBF, and rCBV) calculated using the MCA AIF and CP AIF selected from the left and right hemispheres. Δ GM perfusion metrics (MTT, rCBF, and rCBV) = AIF MCA – AIF CP. The solid line depicts bias, and the dashed lines show the 95% upper and lower limits of agreement as the mean difference.
- FIG 4.
Maps of resting perfusion metrics for the healthy participant shown in Figs 1 and 2, calculated using an AIF from both the MCA and CP.
- FIG 5.
Perfusion maps calculated using an AIF selected from both the MCA and the CP for a patient with a right frontal high-grade glioblastoma. Also shown are the patient's T1-weighted MPRAGE images. Note that leakage correction was not used.
Tables
- Table 1:
ΔS, CNR, and coefficient of variation (mean ± standard error of the mean) indices associated with the GBCA bolus time courses in the right-versus-left MCA and CP
Factor ΔS (%) CNR Mean coefficient of variation (%) Between MCA AIFs 9 (SD, 3) 22 (SD, 3) Between CP AIFs 11 (SD, 3) 24 (SD, 5) - Table 2:
Coefficient of variation between resting perfusion measures (MTT, rCBF, and rCBV) calculated using AIFs from the right-versus-left MCA and right-versus-left CP in the GM and WM
MTT (s) rCBF (a.u) rCBV (a.u) Factor GM WM GM WM GM WM Mean coefficient of variation (%) Between MCA AIFs 14 (SD, 2) 12 (SD, 2) 9 (SD, 2) 11 (SD, 2) 11 (SD, 2) 13 (SD, 3) Between CP AIFs 6 (SD, 2) 5 (SD, 1) 9 (SD, 2) 16 (SD, 5) 11 (SD, 2) 12 (SD, 2)
